{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:43:23Z","timestamp":1792212203064,"version":"4.4.0"},"reference-count":95,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006244","name":"Foundation KiKa","doi-asserted-by":"publisher","award":["278"],"award-info":[{"award-number":["278"]}],"id":[{"id":"10.13039\/501100006244","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Survival of unilateral Wilms tumors (WTs) is exceeding 90%, whereas bilateral WTs have an inferior outcome. We evaluated all Dutch patients with bilateral kidney tumors, treated in the first five years of national centralization and reviewed relevant literature. We identified 24 patients in our center (2015\u20132020), 23 patients had WT\/nephroblastomatosis and one renal cell carcinoma. Patients were treated according to SIOP-RTSG protocols. Chemotherapy response was observed in 26\/34 WTs. Nephroblastomatosis lesions were stable (n = 7) or showed response (n = 18). Nephron-sparing surgery was performed in 11\/22 patients undergoing surgery (n = 2 kidneys positive margins). Local stage in 20 patients with \u22651 WT revealed stage I (n = 7), II (n = 4) and III (n = 9). Histology was intermediate risk in 15 patients and high risk in 5. Three patients developed a WT in a treated nephroblastomatosis lesion. Two of 24 patients died following toxicity and renal failure, i.e., respectively dialysis-related invasive fungal infection and septic shock. Genetic predisposition was confirmed in 18\/24 patients. Our literature review revealed that knowledge is scarce on bilateral renal tumor patients with metastases and that radiotherapy seems important for local stage III patients. Bilateral renal tumors are a therapeutic challenge. We describe management and outcome in a national expert center and summarized available literature, serving as baseline for further improvement of care.<\/jats:p>","DOI":"10.3390\/jcm10235558","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T01:43:22Z","timestamp":1638323002000},"page":"5558","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Bilateral Renal Tumors in Children: The First 5 Years\u2019 Experience of National Centralization in The Netherlands and a Narrative Review of the Literature"],"prefix":"10.3390","volume":"10","author":[{"given":"Sophie E.","family":"van Peer","sequence":"first","affiliation":[{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janna A.","family":"Hol","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alida F. W.","family":"van der Steeg","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine van","family":"Grotel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godelieve A. M.","family":"Tytgat","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6984-3626","authenticated-orcid":false,"given":"Annelies M. C.","family":"Mavinkurve-Groothuis","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert O. R.","family":"Janssens","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands"},{"name":"Department of Radiation Oncology, University Medical Center Utrecht (UMCU), Heidelberglaan 100, 3584 CX Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemieke S.","family":"Littooij","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands"},{"name":"Department of Radiology and Nuclear Medicine, Wilhelmina\u2019s Children Hospital, University Medical Center Utrecht (UMCU), Heidelberglaan 100, 3584 CX Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald R.","family":"de Krijger","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands"},{"name":"Department of Pathology, University Medical Center Utrecht (UMCU), Heidelberglaan 100, 3584 CX Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolijn C. J.","family":"Jongmans","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands"},{"name":"Department of Genetics, University Medical Center Utrecht (UMCU), Heidelberglaan 100, 3584 CX Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R.","family":"Lilien","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands"},{"name":"Department of Pediatric Nephrology, Wilhelmina\u2019s Children Hospital, University Medical Center Utrecht (UMCU), Heidelberglaan 100, 3584 CX Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarno","family":"Drost","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands"},{"name":"Oncode Institute, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4928-3809","authenticated-orcid":false,"given":"Roland P.","family":"Kuiper","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands"},{"name":"Department of Genetics, University Medical Center Utrecht (UMCU), Heidelberglaan 100, 3584 CX Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4626-8702","authenticated-orcid":false,"given":"Harm","family":"van Tinteren","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc H. W. A.","family":"Wijnen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marry M.","family":"van den Heuvel-Eibrink","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology, Princess M\u00e1xima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1002\/ijc.33147","article-title":"Incidence of childhood renal tumours: An international population-based study","volume":"147","author":"Nakata","year":"2020","journal-title":"Int. J. 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