{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:30:06Z","timestamp":1762900206652,"version":"build-2065373602"},"reference-count":34,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T00:00:00Z","timestamp":1637971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1I1A1A01067241"],"award-info":[{"award-number":["2020R1I1A1A01067241"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Chemical labyrinthectomy using gentamicin is a popular method for treating intractable vertigo attacks in Meniere\u2019s disease. However, the risk of hearing loss remains a major concern for clinicians. We investigated the effect of simultaneous dexamethasone and gentamicin application on hearing preservation and vertigo control in patients with intractable unilateral Meniere\u2019s disease. A single-institutional, prospective, single-blinded, randomized clinical trial was conducted. Gentamicin-soaked Gelfoam\u00ae was directly applied on the oval window following middle ear exploration. On the round window, dexamethasone-soaked Gelfoam\u00ae was applied in the gentamicin with dexamethasone group (GD group, n = 18), and saline-soaked Gelfoam\u00ae was applied in the gentamicin with sham reagent group (GO group, n = 19). The hearing change 8 weeks after the procedure and vertigo control 2\u201312 months after the procedure were investigated. The high-frequency hearing threshold was significantly increased in the GO group (p = 0.005 and 0.012 for 4 and 8 kHz, respectively), but not in the GD group. The short-term (2\u20136 months) vertigo control was more successful in the GD group (57.89% vs. 94.44%, p = 0.019), but long-term control (6\u201312 months) was insignificant. In conclusion, the combined application of gentamicin and dexamethasone in chemical labyrinthectomy is an effective method for protecting high-frequency hearing and vertigo control.<\/jats:p>","DOI":"10.3390\/jcm10235581","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T01:43:22Z","timestamp":1638323002000},"page":"5581","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of Dexamethasone Combination with Gentamicin in Chemical Labyrinthectomy on Hearing Preservation and Vertigo Control in Patients with Unilateral Meniere\u2019s Disease: A Randomized Controlled Clinical Trial"],"prefix":"10.3390","volume":"10","author":[{"given":"Seong-Hoon","family":"Bae","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul 03722, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2793-9045","authenticated-orcid":false,"given":"Jeon-Mi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang 10380, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery, Incheon St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 21431, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8111-2124","authenticated-orcid":false,"given":"Gina","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang 10380, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Huhn","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul 03722, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/VES-150549","article-title":"Diagnostic criteria for meniere\u2019s disease","volume":"25","author":"Carey","year":"2015","journal-title":"J. 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