{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T20:51:22Z","timestamp":1784926282065,"version":"3.55.0"},"reference-count":29,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T00:00:00Z","timestamp":1638403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Transbronchial lung forceps biopsy (TBLF) is of limited value for the diagnosis of interstitial lung disease (ILD). However, in cases with predominantly peribronchial pathology, such as sarcoidosis, TBLF is considered to be diagnostic in most cases. The present study examines whether transbronchial lung cryobiopsy (TBLC) is superior to TBLF in terms of diagnostic yield in cases of sarcoidosis. Methods: In this post hoc analysis of a prospective, randomized, controlled, multicentre study, 359 patients with ILD requiring diagnostic bronchoscopic tissue sampling were included. TBLF and TBLC were both used for each patient in a randomized order. Histological assessment was undertaken on each biopsy and determined whether sarcoid was a consideration. Results: A histological diagnosis of sarcoidosis was established in 17 of 272 cases for which histopathology was available. In 6 out of 17 patients, compatible findings were seen with both TBLC and TBLF. In 10 patients, where the diagnosis of sarcoidosis was confirmed by TBLC, TBLF did not provide a diagnosis. In one patient, TBLF but not TBLC confirmed the diagnosis of sarcoidosis. Conclusions: In this post hoc analysis, the histological diagnosis of sarcoidosis was made significantly more often by TBLC than by TBLF. As in other idiopathic interstitial pneumonias (IIPs), the use of TBLC should be considered when sarcoidosis is suspected.<\/jats:p>","DOI":"10.3390\/jcm10235686","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:19:08Z","timestamp":1638479948000},"page":"5686","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Diagnostic Yield of Transbronchial Lung Cryobiopsy Compared to Transbronchial Forceps Biopsy in Patients with Sarcoidosis in a Prospective, Randomized, Multicentre Cross-Over Trial"],"prefix":"10.3390","volume":"10","author":[{"given":"Maik","family":"H\u00e4ntschel","sequence":"first","affiliation":[{"name":"Department of Medical Oncology and Pneumology, Eberhard Karls University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"},{"name":"Department of Internal Medicine\u2014Pneumology, Cantonal Hospital Winterthur, 8400 Winterthur, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Eberhardt","sequence":"additional","affiliation":[{"name":"Department of Pneumology and Critical Care Medicine, Asklepios-Klinik Barmbek, 22307 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Petermann","sequence":"additional","affiliation":[{"name":"Department for Pulmonary Diseases, Asklepios-Klinik Hamburg, 22307 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Gesierich","sequence":"additional","affiliation":[{"name":"Comprehensive Pneumology Center Munich, Asklepios-Fachkliniken Munich-Gauting, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0681-1325","authenticated-orcid":false,"given":"Kaid","family":"Darwiche","sequence":"additional","affiliation":[{"name":"Department of Interventional Pneumology, Ruhrlandklinik\u2014University Medicine Essen, University of Duisburg-Essen, 47057 Duisburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Hagmeyer","sequence":"additional","affiliation":[{"name":"Clinic for Pneumology and Allergology, Center of Sleep Medicine and Respiratory Care, Bethanien Hospital, 42699 Solingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas V.","family":"Colby","sequence":"additional","affiliation":[{"name":"Department of Pathology (Emeritus), Mayo Clinic, Scottsdale, AZ 13400, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falko","family":"Fend","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Neuropathology, Reference Center for Hematopathology University Hospital, Eberhard Karls University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Theegarten","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, 7057 Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanns-Olof","family":"Wintzer","sequence":"additional","affiliation":[{"name":"Institute for Pathology, MVZ Hanse Histologikum, 22547 Hamburg, Germany"},{"name":"Department of Pathology\/Hematopathology, Institute for Hematopathology, 22547 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kreuter","sequence":"additional","affiliation":[{"name":"Center for Interstitial and Rare Lung Diseases, Department of Pneumology, Thoraxklinik, University of Heidelberg and German Center for Lung Research (DZL), 69117 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Spengler","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Pneumology, Eberhard Karls University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika Felicitas","family":"Behrens-Zemek","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Pneumology, Eberhard Karls University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5475-3890","authenticated-orcid":false,"given":"Richard A.","family":"Lewis","sequence":"additional","affiliation":[{"name":"University of Worcester, Worcester WR2 6AJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry C.","family":"Evrard","sequence":"additional","affiliation":[{"name":"Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, 72076 T\u00fcbingen, Germany"},{"name":"Center for Integrative Neuroscience, Eberhard Karls University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"},{"name":"Center for Biomedical Imaging & Neurostimulation, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Ehab","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Pneumology, Eberhard Karls University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"},{"name":"Department of Pneumology, Klinik Loewenstein, 74245 Loewenstein, Germany"},{"name":"Chest Medicine Department, Mansoura University, Mansoura 35516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"B\u00f6ckeler","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Pneumology, Eberhard Karls University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"},{"name":"Department of Internal Medicine, Gastroenterology and Tumor Medicine, 73760 Ostfildern-Ruit, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Hetzel","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Pneumology, Eberhard Karls University of T\u00fcbingen, 72074 T\u00fcbingen, Germany"},{"name":"Department of Internal Medicine\u2014Pneumology, Cantonal Hospital Winterthur, 8400 Winterthur, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1164\/rccm.201807-1255ST","article-title":"Diagnosis of Idiopathic Pulmonary Fibrosis. 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Dis."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/23\/5686\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:38:53Z","timestamp":1760168333000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/23\/5686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,2]]},"references-count":29,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["jcm10235686"],"URL":"https:\/\/doi.org\/10.3390\/jcm10235686","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,2]]}}}