{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:41:55Z","timestamp":1785307315019,"version":"3.55.0"},"reference-count":65,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T00:00:00Z","timestamp":1638748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This prospective and comparative study aimed to compare the use of a conjunctival autograft (CAG), plasma rich in growth factors fibrin membrane (mPRGF) or amniotic membrane transplantation (AMT) in primary pterygium surgery. Patients were assigned for surgery with CAG (group A), mPRGF (group B), or AMT (group C). Pterygium recurrence, Best Corrected Visual Acuity (BCVA), graft size (measured with anterior segment optical coherence tomography (AS-OCT)), and ocular surface symptoms (visual analogue scale (VAS) and ocular surface disease index (OSDI)) were evaluated. Thirteen eyes in group A, 26 in group B, and 10 in group C were evaluated. No changes in BCVA (p &gt; 0.05) were found. Recurrence cases for groups A, B, and C were none, two, and two, respectively, and three cases of pyogenic granulomas in group A. The horizontal\/vertical graft size was lower in group B vs group A (p &lt; 0.05) from months 1 to 12. The improvement in VAS frequency for groups A, B, and C was: 35.5%, 86.2%, and 39.1%, respectively. The OSDI scale reduction for groups A, B, and C was: 12.7%, 39.0%, and 84.1%. The use of the three surgical techniques as a graft for primary pterygium surgery was safe and effective, showing similar results. The mPRGF graft represents an autologous novel approach for pterygium surgery.<\/jats:p>","DOI":"10.3390\/jcm10235711","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T22:18:42Z","timestamp":1638829122000},"page":"5711","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Membrane of Plasma Rich in Growth Factors in Primary Pterygium Surgery Compared to Amniotic Membrane Transplantation and Conjunctival Autograft"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0084-6247","authenticated-orcid":false,"given":"Miriam","family":"Idoipe","sequence":"first","affiliation":[{"name":"Ophthalmology Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9779-879X","authenticated-orcid":false,"given":"Borja","family":"de la Sen-Corcuera","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Laboratory, Biotechnology Institute (BTI), 01007 Vitoria, Spain"},{"name":"Regenerative Medicine Laboratory, University Institute for Regenerative Medicine and Oral Implantology (UIRMI), 01007 Vitoria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5884-6741","authenticated-orcid":false,"given":"Ronald M.","family":"S\u00e1nchez-\u00c1vila","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Laboratory, Biotechnology Institute (BTI), 01007 Vitoria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"S\u00e1nchez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Satu\u00e9","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"S\u00e1nchez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gorka","family":"Orive","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Laboratory, Biotechnology Institute (BTI), 01007 Vitoria, Spain"},{"name":"Regenerative Medicine Laboratory, University Institute for Regenerative Medicine and Oral Implantology (UIRMI), 01007 Vitoria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7359-1698","authenticated-orcid":false,"given":"Francisco","family":"Muruzabal","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Laboratory, Biotechnology Institute (BTI), 01007 Vitoria, Spain"},{"name":"Regenerative Medicine Laboratory, University Institute for Regenerative Medicine and Oral Implantology (UIRMI), 01007 Vitoria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Anitua","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Laboratory, Biotechnology Institute (BTI), 01007 Vitoria, Spain"},{"name":"Regenerative Medicine Laboratory, University Institute for Regenerative Medicine and Oral Implantology (UIRMI), 01007 Vitoria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Pablo","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Miguel Servet University Hospital, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1001\/archopht.1997.01100160405001","article-title":"Effect of pterygium morphology on pterygium recurrence in a controlled trial comparing conjunctival autografting with bare sclera excision","volume":"115","author":"Tan","year":"1997","journal-title":"Arch. 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