{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:21:21Z","timestamp":1791415281351,"version":"4.3.3"},"reference-count":43,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:00:00Z","timestamp":1639008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background. The real impact of septic shock-associated acute kidney injury (AKI) on the long-term renal outcome is still debated, and little is known about AKI-burn patients. In a cohort of burn survivors treated by continuous renal replacement therapy (CRRT) and sorbent technology (CPFA-CRRT), we investigated the long-term outcome of glomerular and tubular function. Methods. Out of 211 burn patients undergoing CRRT from 2001 to 2017, 45 survived, 40 completed the clinical follow-up (cumulative observation period 4067 months, median 84 months, IR 44-173), and 30 were alive on 31 December 2020. Besides creatinine and urine albumin, in the 19 patients treated with CPFA-CRRT, we determined the normalized GFR by 99mTc-DTPA (NRI-GFR) and studied glomerular and tubular urine protein markers. Results. At the follow-up endpoint, the median plasma creatinine and urine albumin were 0.99 (0.72\u20131.19) and 0.0 mg\/dL (0.0\u20130.0), respectively. NRI-GFR was 103.0 mL\/min (93.4\u2013115). Four patients were diabetic, and 22\/30 presented at least one risk factor for chronic disease (hypertension, dyslipidemia, and overweight). Proteinuria decreased over time, from 0.47 g\/day (0.42\u20130.52) at 6 months to 0.134 g\/day (0.09\u20130.17) at follow-up endpoint. Proteinuria positively correlated with the peak of plasma creatinine (r 0.6953, p 0.006) and the number of CRRT days (r 0.5650, p 0.035) during AKI course, and negatively with NRI\u2013GFR (r \u22120.5545, p 0.049). In seven patients, urine protein profile showed a significant increase of glomerular marker albumin and glomerular\/tubular index. Conclusions. Burn patients who experienced septic shock and AKI treated with CRRT had a long-term expectation of preserved renal function. However, these patients were more predisposed to microalbuminuria, diabetes, and the presence of risk factors for intercurrent comorbidities and chronic renal disease.<\/jats:p>","DOI":"10.3390\/jcm10245760","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T21:46:58Z","timestamp":1639086418000},"page":"5760","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Long-Term Preservation of Renal Function in Septic Shock Burn Patients Requiring Renal Replacement Therapy for Acute Kidney Injury"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7137-2141","authenticated-orcid":false,"given":"Filippo","family":"Mariano","sequence":"first","affiliation":[{"name":"Nephrology, Dialysis and Transplantation U, University Hospital City of Science and Health, CTO Hospital, 10126 Torino, Italy"},{"name":"Department of Medical Sciences, University of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Consuelo","family":"De Biase","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Torino, 10126 Torino, Italy"},{"name":"Nephrology and Dialysis Unit, Cardinal Massaia Hospital, 14100 Asti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Hollo","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation U, University Hospital City of Science and Health, CTO Hospital, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Deambrosis","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Torino, 10126 Torino, Italy"},{"name":"Laboratory of Nephrology, University Hospital City of Science and Health, Molinette Hospital, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Davit","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Service, Santa Croce Hospital, 12100 Cuneo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6387-5005","authenticated-orcid":false,"given":"Alberto","family":"Mella","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation U, University Hospital City of Science and Health, CTO Hospital, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Bergamo","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation U, University Hospital City of Science and Health, CTO Hospital, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Maffei","sequence":"additional","affiliation":[{"name":"Nephrology and Dialysis Unit, Cardinal Massaia Hospital, 14100 Asti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6783-6588","authenticated-orcid":false,"given":"Francesca","family":"Rumbolo","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Torino, 10126 Torino, Italy"},{"name":"Clinical Biochemistry Laboratory, University Hospital City of Science and Health, Molinette Hospital, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Papaleo","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Service, Santa Croce Hospital, 12100 Cuneo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Stella","sequence":"additional","affiliation":[{"name":"Burn Center and Plastic Surgery, University Hospital City of Science and Health, CTO Hospital, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Biancone","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation U, University Hospital City of Science and Health, CTO Hospital, 10126 Torino, Italy"},{"name":"Department of Medical Sciences, University of Torino, 10126 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Fortrie, G., de Geus, H.R.H., and Betjes, M.G.H. 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