{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:48:18Z","timestamp":1791215298255,"version":"4.1.0"},"reference-count":41,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007397","name":"Charles University","doi-asserted-by":"publisher","award":["PROGRES Q40\/13"],"award-info":[{"award-number":["PROGRES Q40\/13"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University Hospital Hradec Kr\u00e1lov\u00e9","award":["MH CZ - DRO (UHHK, 00179906)"],"award-info":[{"award-number":["MH CZ - DRO (UHHK, 00179906)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Hematopoietic stem cell transplantation (HSCT) can induce serious oral complications, including oral mucositis (OM). The presence of periodontal inflammation before HSCT is believed to be associated with OM. The aim of our study was to determine the prevalence and severity of OM in patients undergoing HSCT and its relation to periodontal status. Patients and methods: This is a retrospective study of patients who underwent HSCT and a detailed dental examination between 2007 and 2015. The dental and periodontal status of all patients was evaluated by clinical and radiographic examination prior to HSCT. Oral health was assessed with the gingival index, the the community periodontal index, presence of plaque-related gingivitis, and marginal periodontitis. During the HSCT period, patients were examined daily for the presence of OM, which was graded according to World Health Organization (WHO) classification if present. The patients were assigned to the groups according to type of transplantation: autologous HSCT, myeloablative allogeneic HSCT, and non-myeloablative allogeneic HSCT. Results: A total of 496 patients were included in the study. OM was present in 314 of 496 patients (63.3%): 184\/251 (73.3%) in the autologous group, 100\/151 (66.2%) in the myeloablative allogeneic group, and 30\/94 (31.9%) in the nonmyeloablative allogeneic group. Significantly more patients suffered from OM in the autologous and myeloablative groups versus the nonmyeloablative conditioning group (p &lt; 0.001). The presence of periodontal inflammation did not significantly differ among the groups. There was only a borderline trend for the higher prevalence of OM in the non-myeloablative allogeneic nonmyeloablative group when periodontal inflammation was present (0.073939). Conclusions: Oral mucositis prevalence and severity after stem cell transplantation is not widely affected by the oral hygiene and periodontal disease presence before HSCT. We confirmed the wide-known connection of the conditioning regimen intensity to the prevalence of OM.<\/jats:p>","DOI":"10.3390\/jcm10245790","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T01:28:11Z","timestamp":1639358891000},"page":"5790","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Oral Mucositis Association with Periodontal Status: A Retrospective Analysis of 496 Patients Undergoing Hematopoietic Stem Cell Transplantation"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0212-4328","authenticated-orcid":false,"given":"Vladim\u00edra","family":"Radochov\u00e1","sequence":"first","affiliation":[{"name":"Department of Dentistry, University Hospital in Hradec Kr\u00e1lov\u00e9, Faculty of Medicine, Charles University, 50003 Hradec Kralove, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"\u0160embera","sequence":"additional","affiliation":[{"name":"Department of Dentistry, University Hospital in Hradec Kr\u00e1lov\u00e9, Faculty of Medicine, Charles University, 50003 Hradec Kralove, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radovan","family":"Slez\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Dentistry, University Hospital in Hradec Kr\u00e1lov\u00e9, Faculty of Medicine, Charles University, 50003 Hradec Kralove, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8119-0640","authenticated-orcid":false,"given":"Ond\u0159ej","family":"Heneberk","sequence":"additional","affiliation":[{"name":"Department of Dentistry, University Hospital in Hradec Kr\u00e1lov\u00e9, Faculty of Medicine, Charles University, 50003 Hradec Kralove, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Radocha","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine-Hematology, University Hospital in Hradec Kr\u00e1lov\u00e9, Faculty of Medicine, Charles University, 50003 Hradec Kralove, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/sj.bmt.1705429","article-title":"A prospective study to evaluate a new dental management protocol before hematopoietic stem cell transplantation","volume":"38","author":"Yamagata","year":"2006","journal-title":"Bone Marrow Transplant."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1002\/(SICI)1097-0142(19990415)85:8<1843::AID-CNCR26>3.0.CO;2-R","article-title":"A Prospective Pilot Study to Evaluate a New Dental Assessment and Treatment Paradigm for Patients Scheduled to Undergo Intensive Chemotherapy for Cancer","volume":"85","author":"Toljanic","year":"1999","journal-title":"Cancer"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s00520-003-0499-8","article-title":"Time limitations and the challenge of providing infection-preventing dental care to hematopoietic stem-cell transplantation patients","volume":"11","author":"Elad","year":"2003","journal-title":"Support. 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