{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:39:19Z","timestamp":1790127559739,"version":"4.0.1"},"reference-count":68,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Dystrophic Epidermolysis Bullosa Research Association United Kingdom","award":["Jonkman 1"],"award-info":[{"award-number":["Jonkman 1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Epidermolysis bullosa (EB) is a genetic blistering skin condition for which no cure exists. Symptom alleviation and quality of life are therefore central to EB care. This study aimed to gain insight into EB patient needs and benefits from current clinical care. Two questionnaires were administered cross-sectionally to adult EB patients at the Dutch expertise centre for blistering diseases. Patient needs and benefits were analyzed using the patient benefit index survey (PBI-S). Ancillary data were compiled pertaining to self-reported EB severity, pain and pruritus, as well as current and previous treatments. In total, 104 participants were included (response rate 69.8%). Sixty-eight participants comprised the analyzed cohort (n = 36 omitted from analysis). The needs given the highest importance were to get better skin quickly (64.7%) and to be healed of all skin alterations (61.8%). A positive correlation between pain and EB severity and the importance of most needs was observed. Minimal clinically important differences within the PBI-S, relating to reported benefits from clinical care, were reported by 60.3% of the cohort. This study highlights a discrepancy between patient needs and feasible treatment outcomes. Utilizing the PBI-S in conjunction with well-established multidisciplinary care may catalyze the process of tailoring treatments to the needs of individual patients.<\/jats:p>","DOI":"10.3390\/jcm10245836","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T01:20:41Z","timestamp":1639444841000},"page":"5836","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Identifying Epidermolysis Bullosa Patient Needs and Perceived Treatment Benefits: An Explorative Study Using the Patient Benefit Index"],"prefix":"10.3390","volume":"10","author":[{"given":"Nicholas H. B.","family":"Schr\u00e4der","sequence":"first","affiliation":[{"name":"Department of Dermatology, University Medical Centre Groningen, University of Groningen, 9700 RB Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9166-5654","authenticated-orcid":false,"given":"Eva W. H.","family":"Korte","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Centre Groningen, University of Groningen, 9700 RB Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 C.","family":"Duipmans","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Centre Groningen, University of Groningen, 9700 RB Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy E.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Public Health, University Medical Centre Groningen, University of Groningen, 9700 RB Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Bolling","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Centre Groningen, University of Groningen, 9700 RB Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 P.","family":"Wolff","sequence":"additional","affiliation":[{"name":"Anaesthesiology Pain Centre, University Medical Centre Groningen, University of Groningen, 9700 RB Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/bjd.18921","article-title":"Consensus reclassification of inherited epidermolysis bullosa and other disorders with skin fragility","volume":"183","author":"Has","year":"2020","journal-title":"Br. J. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1111\/bjd.16797","article-title":"Cardiomyopathy in patients with epidermolysis bullosa simplex with mutations in KLHL24","volume":"179","author":"Yenamandra","year":"2018","journal-title":"Br. J. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1590\/S0365-05962013000200001","article-title":"Inherited epidermolysis bullosa: Clinical and therapeutic aspects","volume":"88","author":"Boeira","year":"2013","journal-title":"An. Bras. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"442","DOI":"10.2340\/00015555-1758","article-title":"Health-related quality of life in epidermolysis bullosa: Validation of the dutch QOLEB questionnaire and assessment in the dutch population","volume":"94","author":"Yuen","year":"2014","journal-title":"Acta Dermatol. Venereol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1046\/j.1365-2230.2002.01121.x","article-title":"Quality of life in epidermolysis bullosa","volume":"27","author":"Horn","year":"2002","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"6","DOI":"10.5021\/ad.2016.28.1.6","article-title":"Quality of life and economic burden in recessive dystrophic epidermolysis bullosa","volume":"28","author":"Jeon","year":"2016","journal-title":"Ann. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1586\/erp.10.28","article-title":"Factors affecting quality of life in epidermolysis bullosa","volume":"10","author":"Pagliarello","year":"2010","journal-title":"Expert Rev. Pharmacoecon. Outcomes Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1007\/s11136-020-02495-5","article-title":"Quality of life in people with epidermolysis bullosa: A systematic review","volume":"29","author":"Togo","year":"2020","journal-title":"Qual. Life Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13023-019-1279-y","article-title":"The challenges of living with and managing epidermolysis bullosa: Insights from patients and caregivers","volume":"15","author":"Bruckner","year":"2020","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12916-014-0178-2","article-title":"Pain care for patients with epidermolysis bullosa: Best care practice guidelines","volume":"12","author":"Goldschneider","year":"2014","journal-title":"BMC Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13023-019-1059-8","article-title":"Occupational therapy for epidermolysis bullosa: Clinical practice guidelines","volume":"14","author":"Chan","year":"2019","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jid.2015.10.050","article-title":"Progress toward Treatment and Cure of Epidermolysis Bullosa: Summary of the DEBRA International Research Symposium EB2015","volume":"136","author":"Uitto","year":"2016","journal-title":"J. Investig. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s13023-019-1086-5","article-title":"Psychosocial recommendations for the care of children and adults with epidermolysis bullosa and their family: Evidence based guidelines","volume":"14","author":"Martin","year":"2019","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/mgg3.315","article-title":"Living with a rare disorder: A systematic review of the qualitative literature","volume":"5","author":"Diesen","year":"2017","journal-title":"Mol. Genet. Genom. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/jdv.17012","article-title":"Novel insights into the epidemiology of epidermolysis bullosa (EB) from the Dutch EB Registry: EB more common than previously assumed?","volume":"35","author":"Baardman","year":"2021","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00403-009-0928-8","article-title":"The patient benefit index: A novel approach in patient-defined outcomes measurement for skin diseases","volume":"301","author":"Augustin","year":"2009","journal-title":"Arch. Dermatol. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00403-010-1073-0","article-title":"Dimensions of patient needs in dermatology: Subscales of the patient benefit index","volume":"303","author":"Blome","year":"2011","journal-title":"Arch. Dermatol. Res."},{"key":"ref_18","first-page":"69","article-title":"Statistics corner: A guide to appropriate use of correlation coefficient in medical research","volume":"24","author":"Mukaka","year":"2012","journal-title":"Malawi Med. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/pde.12391","article-title":"Prevalence and characterization of pruritus in epidermolysis bullosa","volume":"32","author":"Danial","year":"2015","journal-title":"Pediatr. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1093\/brain\/awx069","article-title":"Recessive dystrophic epidermolysis bullosa results in painful small fibre neuropathy","volume":"140","author":"Ivulic","year":"2017","journal-title":"Brain"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1111\/bjd.19496","article-title":"Prevalence, pathophysiology and management of itch in epidermolysis bullosa*","volume":"184","author":"Papanikolaou","year":"2021","journal-title":"Br. J. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s13023-017-0666-5","article-title":"Pain and quality of life evaluation in patients with localized epidermolysis bullosa simplex","volume":"12","author":"Brun","year":"2017","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/S0140-6736(21)00392-5","article-title":"Nociplastic pain: Towards an understanding of prevalent pain conditions","volume":"397","author":"Fitzcharles","year":"2021","journal-title":"Lancet"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"346","DOI":"10.2340\/00015555-2827","article-title":"Pain quality assessment scale for epidermolysis bullosa","volume":"98","author":"Yuen","year":"2018","journal-title":"Acta Dermatol. Venereol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"746","DOI":"10.4306\/pi.2017.14.6.746","article-title":"Pain in patients with dystrophic epidermolysis bullosa: Association with anxiety and depression","volume":"14","author":"Fortuna","year":"2017","journal-title":"Psychiatry Investig."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/bjd.12885","article-title":"Burden of itch in epidermolysis bullosa","volume":"171","author":"Snauwaert","year":"2014","journal-title":"Br. J. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2340\/00015555-0376","article-title":"Main problems experienced by children with epidermolysis bullosa: A qualitative study with semi-structured interviews","volume":"88","author":"Lettinga","year":"2008","journal-title":"Acta Dermatol. Venereol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"783","DOI":"10.2340\/00015555-3179","article-title":"Impact of painful wound care in epidermolysis bullosa during childhood: An interview study with adult patients and parents","volume":"99","author":"Mauritz","year":"2019","journal-title":"Acta Dermatol. Venereol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"244","DOI":"10.4103\/idoj.IDOJ_287_18","article-title":"Newer treatment modalities in epidermolysis bullosa","volume":"10","year":"2019","journal-title":"Indian Dermatol. Online J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40257-013-0059-z","article-title":"Treatment of hereditary epidermolysis bullosa: Updates and future prospects","volume":"15","author":"Hsu","year":"2014","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.jid.2017.12.016","article-title":"EB2017\u2014Progress in Epidermolysis Bullosa Research toward Treatment and Cure","volume":"138","author":"Uitto","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/pde.12486","article-title":"Evaluation of Treatments for Pruritus in Epidermolysis Bullosa","volume":"32","author":"Danial","year":"2015","journal-title":"Pediatr. Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"105","DOI":"10.36076\/ppj.2008\/11\/S105","article-title":"Opioid complications and side effects","volume":"11","author":"Benyamin","year":"2008","journal-title":"Pain Phys."},{"key":"ref_34","first-page":"CD012509","article-title":"Adverse events associated with medium- and long-term use of opioids for chronic non-cancer pain: An overview of Cochrane Reviews","volume":"10","author":"Els","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"i2709","DOI":"10.1136\/bmj.i2709","article-title":"Nicotine has deleterious effects on wound healing through increased vasoconstriction","volume":"17","author":"Davies","year":"2016","journal-title":"BMJ"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1365-4632.2011.05205.x","article-title":"Smoking and the skin","volume":"51","author":"Ortiz","year":"2012","journal-title":"Int. J. Dermatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jpain.2016.11.009","article-title":"Analgesic Effects of Alcohol: A Systematic Review and Meta-Analysis of Controlled Experimental Studies in Healthy Participants","volume":"18","author":"Thompson","year":"2017","journal-title":"J. Pain"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cpr.2015.02.005","article-title":"Interrelations between pain and alcohol: An integrative review","volume":"37","author":"Zale","year":"2015","journal-title":"Clin. Psychol. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/bjd.17619","article-title":"Time to drop the stigma: Cannabinoids are drugs that may alleviate pain in people with epidermolysis bullosa","volume":"180","author":"Martinez","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/bjd.17341","article-title":"Combined tetrahydrocannabinol and cannabidiol to treat pain in epidermolysis bullosa: A report of three cases","volume":"180","author":"Duipmans","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e224","DOI":"10.1111\/pde.13545","article-title":"Self-initiated use of topical cannabidiol oil for epidermolysis bullosa","volume":"35","author":"Chelliah","year":"2018","journal-title":"Pediatr. Dermatol."},{"key":"ref_42","first-page":"1","article-title":"Cannabinoid use and effects in patients with epidermolysis bullosa: An international cross-sectional survey study","volume":"16","author":"Gorell","year":"2021","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Condorelli, A.G., Dellambra, E., Logli, E., Zambruno, G., and Castiglia, D. (2019). Epidermolysis bullosa-associated squamous cell carcinoma: From pathogenesis to therapeutic perspectives. Int. J. Mol. Sci., 14.","DOI":"10.3390\/ijms20225707"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1750-1172-9-76","article-title":"Multicentre consensus recommendations for skin care in inherited epidermolysis bullosa","volume":"9","author":"Zambruno","year":"2014","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_45","first-page":"547","article-title":"Injury- and inflammation-driven skin fibrosis: The paradigm of epidermolysis bullosa","volume":"68\u201369","year":"2018","journal-title":"Matrix Biol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Gal, R., Oostinga, D., Wessels, H., Verlaan, J.J., Charest-Morin, R., Fisher, C.G., Verkooijen, H.M., and Versteeg, A.L. (2020). Pre-treatment expectations of patients with spinal metastases: What do we know and what can we learn from other disciplines? A systematic review of qualitative studies. BMC Cancer, 20.","DOI":"10.1186\/s12885-020-07683-7"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2217\/ijr.15.38","article-title":"How to manage patients\u2019 expectations in rheumatoid arthritis treatment","volume":"10","author":"Lempp","year":"2015","journal-title":"Int. J. Clin. Rheumtol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"163","DOI":"10.4103\/0974-2700.82199","article-title":"Patient expectations and the paradigm shift of care in emergency medicine","volume":"4","author":"Lateef","year":"2011","journal-title":"J. Emergencies Trauma Shock"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10198-016-0783-4","article-title":"Social\/economic costs and health-related quality of life in patients with epidermolysis bullosa in Europe","volume":"17","author":"Angelis","year":"2016","journal-title":"Eur. J. Health Econ."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/1346-8138.13027","article-title":"Role of dystrophic epidermolysis bullosa in anxiety, depression and self-esteem: A controlled cross-sectional study","volume":"43","author":"Fortuna","year":"2016","journal-title":"J. Dermatol."},{"key":"ref_51","first-page":"12","article-title":"Depression and pain: Implications for symptomatic presentation and pharmacological treatments","volume":"2","author":"Kleiber","year":"2005","journal-title":"Psychiatry"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13023-020-01640-0","article-title":"Supporting sexuality for people living with epidermolysis bullosa: Clinical practice guidelines","volume":"16","author":"King","year":"2021","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/j.1365-2133.2009.09306.x","article-title":"Quality of life in patients with epidermolysis bullosa","volume":"161","author":"Tabolli","year":"2009","journal-title":"Br. J. Dermatol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1111\/bjd.12267","article-title":"Gender differences in chronic pruritus: Women present different morbidity, more scratch lesions and higher burden","volume":"168","author":"Stumpf","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Lavery, M.J., Stull, C., Kinney, M.O., and Yosipovitch, G. (2016). Nocturnal pruritus: The battle for a peaceful night\u2019s sleep. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17030425"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/jdv.13953","article-title":"The Epidermolysis Bullosa Disease Activity and Scarring Index (EBDASI): Grading disease severity and assessing responsiveness to clinical change in epidermolysis bullosa","volume":"31","author":"Jain","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.dsi.2017.07.003","article-title":"Sleep quality and disturbances in patients with dystrophic epidermolysis bullosa","volume":"36","author":"Fortuna","year":"2018","journal-title":"Dermatol. Sin."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1111\/jpc.15089","article-title":"Epidermolysis bullosa and the importance of evaluation of sleep complaints","volume":"56","author":"Xerfan","year":"2020","journal-title":"J. Paediatr. Child. Health"},{"key":"ref_59","first-page":"112","article-title":"Stress and quality of life in patients with epidermolysis bullosa","volume":"14","author":"RMT","year":"2016","journal-title":"Dermatol. Cosm\u00e9tica M\u00e9d. Quir\u00fargica"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1519\/JPT.0000000000000055","article-title":"Does age affect the relationship between pain and disability? A descriptive study in individuals suffering from chronic low back pain","volume":"39","author":"Houde","year":"2016","journal-title":"J. Geriatr. Phys. Ther."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/01.ajp.0000146217.31780.ef","article-title":"Age and the experience of chronic pain: Differences in health and quality of life among younger, middle-aged, and older adults","volume":"21","author":"Wahl","year":"2005","journal-title":"Clin. J. Pain"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neubiorev.2017.01.039","article-title":"Age changes in pain perception: A systematic-review and meta-analysis of age effects on pain and tolerance thresholds","volume":"75","author":"Lautenbacher","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/hex.13006","article-title":"Living with epidermolysis bullosa: Daily challenges and health-care needs","volume":"23","author":"Kearney","year":"2020","journal-title":"Health Expect."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jval.2014.10.007","article-title":"Measuring change in quality of life: Bias in prospective and retrospective evaluation","volume":"18","author":"Blome","year":"2015","journal-title":"Value Health"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00403-012-1256-y","article-title":"Validation of the patient benefit index for the assessment of patient-relevant benefit in the treatment of psoriasis","volume":"304","author":"Feuerhahn","year":"2012","journal-title":"Arch. Dermatol. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00403-016-1648-5","article-title":"Development and validation of the Patient Benefit Index for the dermatocosmetic treatment of aged skin","volume":"308","author":"Lohrberg","year":"2016","journal-title":"Arch. Dermatol. Res."},{"key":"ref_67","first-page":"219","article-title":"Development and validation of the Patient Benefit Index for peripheral arterial disease","volume":"47","author":"Zander","year":"2018","journal-title":"Vasa Eur. J. Vasc. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1524-475X.2011.00751.x","article-title":"Benefit evaluation in the therapy of chronic wounds from the patients\u2019 perspective-development and validation of a new method","volume":"20","author":"Augustin","year":"2012","journal-title":"Wound Repair Regen."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/24\/5836\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:46:38Z","timestamp":1760168798000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/24\/5836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,13]]},"references-count":68,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["jcm10245836"],"URL":"https:\/\/doi.org\/10.3390\/jcm10245836","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,13]]}}}