{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:46:48Z","timestamp":1788965208155,"version":"build-2803163510"},"reference-count":154,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Tissue hypoxia occurs in various conditions such as myocardial or brain ischemia and infarction, sepsis, and trauma, and induces cellular damage and tissue remodeling with recapitulation of fetal-like reprogramming, which eventually results in organ failure. Analogies seem to exist between the damaged hypoxic and developing organs, indicating that a regulatory network which drives embryonic organ development may control aspects of heart (or tissue) repair. In this context, thyroid hormone (TH), which is a critical regulator of organ maturation, physiologic angiogenesis, and mitochondrial biogenesis during fetal development, may be of important physiological relevance upon stress (hypoxia)-induced fetal reprogramming. TH signaling has been implicated in hypoxic tissue remodeling after myocardial infarction and T3 prevents remodeling of the postinfarcted heart. Similarly, preliminary experimental evidence suggests that T3 can prevent early tissue hypoxia during sepsis with important physiological consequences. Thus, based on common pathways between different paradigms, we propose a possible role of TH in tissue hypoxia after sepsis with the potential to reduce secondary organ failure.<\/jats:p>","DOI":"10.3390\/jcm10245855","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T11:11:35Z","timestamp":1639480295000},"page":"5855","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Effects of Thyroid Hormone on Tissue Hypoxia: Relevance to Sepsis Therapy"],"prefix":"10.3390","volume":"10","author":[{"given":"Athanasios I.","family":"Lourbopoulos","sequence":"first","affiliation":[{"name":"Department of Pharmacology, National and Kapodistrian University of Athens, 75 Mikras Asias Ave, Goudi, 11527 Athens, Greece"},{"name":"Institute for Stroke and Dementia Research (ISD), University of Munich Medical Center, 81377 Munich, Germany"},{"name":"Neurointensive Care Unit, Schoen Klinik Bad Aibling, Kolbermoorerstrasse 72, 83043 Bad Aibling, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iordanis S.","family":"Mourouzis","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, National and Kapodistrian University of Athens, 75 Mikras Asias Ave, Goudi, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios G.","family":"Trikas","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, National and Kapodistrian University of Athens, 75 Mikras Asias Ave, Goudi, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioulia K.","family":"Tseti","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, National and Kapodistrian University of Athens, 75 Mikras Asias Ave, Goudi, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos I.","family":"Pantos","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, National and Kapodistrian University of Athens, 75 Mikras Asias Ave, Goudi, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fendo.2012.00008","article-title":"New Insights toward the Acute Non-Thyroidal Illness Syndrome","volume":"3","author":"Wajner","year":"2012","journal-title":"Front. 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