{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T23:35:54Z","timestamp":1772494554365,"version":"3.50.1"},"reference-count":102,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Center","doi-asserted-by":"publisher","award":["2016\/21\/B\/NZ5\/01378"],"award-info":[{"award-number":["2016\/21\/B\/NZ5\/01378"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Mechanical reperfusion with primary angioplasty, as the treatment of choice in acute myocardial infarction (MI), is associated not only with a high percentage of full epicardial and tissue reperfusion but also with a very good immediate and long-term clinical outcome. However, the Achilles heel of MI treatment is its ensemble of complications, such as cardiogenic shock due to severe systolic and\/or diastolic dysfunction or MI mechanical complications, including perforation of the left ventricular free wall, papillary muscle rupture with acute mitral regurgitation and ventricular septal rupture. They are associated with an increased or, sometimes, with an extremely high mortality rate, determining the overall mortality in an MI patient population. In this review we summarize the mechanisms of MI complications, current therapeutic management and alternative directions for overcoming their devastating consequences. Moreover, we have sought to indicate gaps in the evidence on current treatments as the potential targets for further clinical research. From the perspective of mortality trends that are not improving, the forthcoming therapeutic management of complicated MI will require an individualized and novel approach based on their thorough pathobiology.<\/jats:p>","DOI":"10.3390\/jcm10245904","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T11:27:36Z","timestamp":1639654056000},"page":"5904","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Complicating Acute Myocardial Infarction. Current Status and Unresolved Targets for Subsequent Research"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4374-3694","authenticated-orcid":false,"given":"Jaroslaw","family":"Zalewski","sequence":"first","affiliation":[{"name":"Department of Coronary Disease and Heart Failure, Jagiellonian University Medical College, 80 Pradnicka Street, 31-202 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2474-5512","authenticated-orcid":false,"given":"Karol","family":"Nowak","sequence":"additional","affiliation":[{"name":"Department of Coronary Disease and Heart Failure, Jagiellonian University Medical College, 80 Pradnicka Street, 31-202 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8538-467X","authenticated-orcid":false,"given":"Patrycja","family":"Furczynska","sequence":"additional","affiliation":[{"name":"Department of Coronary Disease and Heart Failure, Jagiellonian University Medical College, 80 Pradnicka Street, 31-202 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7444-987X","authenticated-orcid":false,"given":"Magdalena","family":"Zalewska","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Faculty of Health Science, Jagiellonian University Medical College, Michalowskiego 12 Street, 31-126 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"ref_1","unstructured":"OECD\/European Union (2020). Health at a Glance: Europe 2020: State of Health in the EU Cycle, OECD Publishing."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1093\/eurheartj\/eht529","article-title":"European Association for Percutaneous Cardiovascular Interventions. Reperfusion therapy for ST elevation acute myocardial infarction 2010\/2011: Current status in 37 ESC countries","volume":"35","author":"Kristensen","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/ejhf.1769","article-title":"Composite trends of cardiogenic shock complicating acute myocardial infarction","volume":"22","author":"Savonitto","year":"2020","journal-title":"Eur. J. Heart Fail."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Garc\u00eda, C., Oliveras, T., El Ouaddi, N., Rueda, F., Serra, J., Labata, C., Ferrer, M., Cediel, G., Montero, S., and Mart\u00ednez, M.J. (2020). Short- and Long-Term Mortality Trends in STEMI-Cardiogenic Shock over Three Decades (1989\u20132018): The Ruti-STEMI-Shock Registry. J. Clin. Med., 9.","DOI":"10.3390\/jcm9082398"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ahj.2020.08.012","article-title":"Trends in first-time hospitalization, management, and short-term mortality in acute myocardial infarction\u2013related cardiogenic shock from 2005 to 2017: A nationwide cohort study","volume":"229","author":"Lauridsen","year":"2020","journal-title":"Am. Heart J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e000590","DOI":"10.1161\/JAHA.113.000590","article-title":"Trends in Incidence, Management, and Outcomes of Cardiogenic Shock Complicating ST-Elevation Myocardial Infarction in the United States","volume":"3","author":"Kolte","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/j.jcin.2019.04.039","article-title":"Temporal Trends and Outcomes of Mechanical Complications in Patients With Acute Myocardial Infarction","volume":"12","author":"Elbadawi","year":"2019","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jacc.2018.06.031","article-title":"Temporal Trends in Mechanical Complications of Acute Myocardial Infarction in the Elderly","volume":"72","author":"Puerto","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S0735-1097(00)00879-2","article-title":"Cardiogenic shock complicating acute myocardial infarction\u2014etiologies, management and outcome: A report from the SHOCK Trial Registry. Should we emergently revascularize Occluded Coronaries for cardiogenic shock?","volume":"36","author":"Hochman","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.jacc.2018.06.032","article-title":"Mechanical Complications in Elderly Patients with Myocardial Infarction: Becoming fewer but just as fatal","volume":"72","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1097\/JIM.0000000000000232","article-title":"Acute Complications of Myocardial Infarction in the Current Era: Diagnosis and management","volume":"63","author":"Bajaj","year":"2015","journal-title":"J. Investig. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/2048872619894254","article-title":"Acute Cardiovascular Care Association position statement for the diagnosis and treatment of patients with acute myocardial infarction complicated by cardiogenic shock: A document of the Acute Cardiovascular Care Association of the European Society of Cardiology","volume":"9","author":"Zeymer","year":"2020","journal-title":"Eur. Heart J. Acute Cardiovasc. Care"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.mcna.2007.03.006","article-title":"Pathophysiology of Cardiogenic Shock Complicating Acute Myocardial Infarction","volume":"91","author":"Aymong","year":"2007","journal-title":"Med. Clin. N. Am."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.jacc.2004.03.060","article-title":"Cardiac power is the strongest hemodynamic correlate of mortality in cardiogenic shock: A report from the SHOCK trial registry","volume":"44","author":"Fincke","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.hfc.2020.02.002","article-title":"Cardiac Mechanoenergetics in Patients with Acute Myocardial Infarction: From pressure-volume loop diagram related to cardiac oxygen consumption","volume":"16","author":"Hieda","year":"2020","journal-title":"Heart Fail. Clin."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/clc.22564","article-title":"Cardiogenic Shock: Failure of Oxygen Delivery and Oxygen Utilization","volume":"39","author":"Lim","year":"2016","journal-title":"Clin. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.chest.2019.03.020","article-title":"Reconsidering Vasopressors for Cardiogenic Shock: Everything should be made as simple as possible, but not simpler","volume":"156","author":"Squara","year":"2019","journal-title":"Chest"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e007678","DOI":"10.1161\/CIRCHEARTFAILURE.120.007678","article-title":"Defining shock and preshock for mortality risk stratification in cardiac intensive care unit patients","volume":"14","author":"Jentzer","year":"2021","journal-title":"Circ Heart Fail."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/ccd.28329","article-title":"SCAI clinical expert consensus statement on the classification of cardiogenic shock: This document was endorsed by the American College of Cardiology (ACC), the American Heart Association (AHA), the Society of Critical Care Medicine (SCCM), and the Society of Thoracic Surgeons (STS) in April 2019","volume":"94","author":"Baran","year":"2019","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1002\/ejhf.1922","article-title":"Epidemiology, pathophysiology and contemporary management of cardiogenic shock\u2014A position statement from the Heart Failure Association of the European Society of Cardiology","volume":"22","author":"Chioncel","year":"2020","journal-title":"Eur. J. Heart Fail."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1097\/00003246-200005000-00005","article-title":"Microvascular response in patients with cardiogenic shock","volume":"28","author":"Kirschenbaum","year":"2000","journal-title":"Crit. Care Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1177\/2048872619870035","article-title":"Prognostic implications of microcirculatory perfusion versus macrocirculatory perfusion in cardiogenic shock: A CULPRIT-SHOCK substudy","volume":"9","author":"Wijntjens","year":"2020","journal-title":"Eur. Heart J. Acute Cardiovasc. Care"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3233\/CH-16156","article-title":"Effect of increasing mean arterial blood pressure on microcirculation in patients with cardiogenic shock supported by extracorporeal membrane oxygenation","volume":"70","author":"Du","year":"2018","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/MCA.0000000000000259","article-title":"Acute myocardial infarction and cardiogenic shock: Pharmacologic and mechanical hemodynamic support pathways","volume":"26","author":"Graf","year":"2015","journal-title":"Coron. Artery Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00392-011-0403-3","article-title":"Interleukin-6, -7, -8 and -10 predict outcome in acute myocardial infarction complicated by cardiogenic shock","volume":"101","author":"Prondzinsky","year":"2012","journal-title":"Clin. Res. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/ejhf.872","article-title":"Organ dysfunction, injury and failure in acute heart failure: From pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)","volume":"19","author":"Harjola","year":"2017","journal-title":"Eur. J. Heart Fail."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1001\/archinte.165.14.1643","article-title":"Systemic Inflammatory Response Syndrome After Acute Myocardial Infarction Complicated by Cardiogenic Shock","volume":"165","author":"Kohsaka","year":"2005","journal-title":"Arch. Intern. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/SHK.0000000000000756","article-title":"Infectious Complications and Immune\/Inflammatory Response in Cardiogenic Shock Patients: A prospective observational study","volume":"47","author":"Parenica","year":"2017","journal-title":"Shock"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.cardfail.2015.09.017","article-title":"Intersections Between Microbiome and Heart Failure: Revisiting the Gut Hypothesis","volume":"21","author":"Nagatomo","year":"2015","journal-title":"J. Card. Fail."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/0002-9343(92)90203-N","article-title":"Interventricular septal rupture complicating acute myocardial infarction: From pathophysiologic features to the role of invasive and noninvasive diagnostic modalities in current management","volume":"93","author":"Topaz","year":"1992","journal-title":"Am. J. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0735-1097(00)00845-7","article-title":"Cardiogenic shock due to cardiac free-wall rupture or tamponade after acute myocardial infarction: A report from the SHOCK Trial Registry. Should we emergently revascularize occluded coronaries for cardiogenic shock?","volume":"36","author":"Slater","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1056\/NEJMra020228","article-title":"Ventricular Septal Rupture after Acute Myocardial Infarction","volume":"347","author":"Birnbaum","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1161\/01.CIR.101.1.27","article-title":"Risk Factors, Angiographic Patterns, and Outcomes in Patients with Ventricular Septal Defect Complicating Acute Myocardial Infarction. GUSTO-I (Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries) Trial Investigators","volume":"101","author":"Crenshaw","year":"2000","journal-title":"Circulation"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1378\/chest.125.5.1622","article-title":"The Potential Impact of Primary Percutaneous Coronary Intervention on Ventricular Septal Rupture Complicating Acute Myocardial Infarction","volume":"125","author":"Yip","year":"2004","journal-title":"Chest"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1053\/euhj.2002.3193","article-title":"A prospective survey of the characteristics, treatments and outcomes of patients with acute coronary syndromes in Europe and the Mediterranean basin. The Euro Heart Survey of Acute Coronary Syndromes (Euro Heart Survey ACS)","volume":"23","author":"Hasdai","year":"2002","journal-title":"Eur. Heart J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1093\/eurheartj\/ehq061","article-title":"Factors related to heart rupture in acute coronary syndromes in the Global Registry of Acute Coronary Events","volume":"31","author":"Gurfinkel","year":"2010","journal-title":"Eur. Heart J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0002-9149(88)91357-4","article-title":"Acquired ventricular septal defect during acute myocardial infarction: Analysis of 38 unoperated necropsy patients and comparison with 50 unoperated necropsy patients without rupture","volume":"62","author":"Mann","year":"1988","journal-title":"Am. J. Cardiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0022-5223(98)70117-5","article-title":"Early systolic mitral leaflet \u201cloitering\u201d during acute ischemic mitral regurgitation","volume":"116","author":"Glasson","year":"1998","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/01.CIR.96.3.827","article-title":"Clinical Significance of Mitral Regurgitation After Acute Myocardial Infarction","volume":"96","author":"Lamas","year":"1997","journal-title":"Circulation"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0735-1097(86)80182-6","article-title":"Rupture of a left ventricular papillary muscle during acute myocardial infarction: Analysis of 22 necropsy patients","volume":"8","author":"Barbour","year":"1986","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/0002-8703(66)90475-3","article-title":"The anatomy and blood supply of the papillary muscles of the left ventricle","volume":"71","author":"Estes","year":"1966","journal-title":"Am. Heart J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1093\/ejcts\/ezt150","article-title":"Mitral valve repair for post-myocardial infarction papillary muscle rupture","volume":"44","author":"Bouma","year":"2013","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13019-014-0171-z","article-title":"Predictors of in-hospital mortality after mitral valve surgery for post-myocardial infarction papillary muscle rupture","volume":"9","author":"Bouma","year":"2014","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1111\/jocs.15701","article-title":"Meta-analysis of surgical treatment for postinfarction left ventricular free-wall rupture","volume":"36","author":"Matteucci","year":"2021","journal-title":"J. Card. Surg."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/ejhf.1750","article-title":"Trends in cardiogenic shock complicating acute myocardial infarction","volume":"22","author":"Aissaoui","year":"2020","journal-title":"Eur. J. Heart Fail."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/CRD.0000000000000190","article-title":"Predictors of Outcomes in Myocardial Infarction and Cardiogenic Shock","volume":"26","author":"Acharya","year":"2018","journal-title":"Cardiol. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.ijcard.2015.10.225","article-title":"Predicting ischemic mitral regurgitation in patients with acute ST-elevation myocardial infarction: Does time to reperfusion really matter and what is the role of collateral circulation?","volume":"203","author":"Valuckiene","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.athoracsur.2012.10.050","article-title":"Clinical Outcome After Mitral Valve Surgery Due to Ischemic Papillary Muscle Rupture","volume":"95","author":"Schroeter","year":"2013","journal-title":"Ann. Thorac. Surg."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.amjcard.2013.06.009","article-title":"Therapeutic Management Changes and Mortality Rates over 30 Years in Ventricular Septal Rupture Complicating Acute Myocardial Infarction","volume":"112","author":"Mewton","year":"2013","journal-title":"Am. J. Cardiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.amjcard.2010.06.013","article-title":"Trends in Incidence and Mortality Rates of Ventricular Septal Rupture During Acute Myocardial Infarction","volume":"106","author":"Moreyra","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1093\/eurheartj\/ehz294","article-title":"Protein-based cardiogenic shock patient classifier","volume":"40","author":"Rueda","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1056\/NEJM199908263410901","article-title":"Early Revascularization in Acute Myocardial Infarction Complicated by Cardiogenic Shock","volume":"341","author":"Hochman","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1001\/jama.295.21.2511","article-title":"Early Revascularization and Long-term Survival in Cardiogenic Shock Complicating Acute Myocardial Infarction","volume":"295","author":"Hochman","year":"2006","journal-title":"JAMA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/eurheartj\/ehy394","article-title":"2018 ESC\/EACTS Guidelines on myocardial revascularization","volume":"40","author":"Neumann","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Gim\u00e9nez, M.R., Miller, P.E., Alviar, C.L., Van Diepen, S., Granger, C.B., Montalescot, G., Windecker, S., Maier, L., Serpytis, P., and Serpytis, R. (2020). Outcomes Associated with Respiratory Failure for Patients with Cardiogenic Shock and Acute Myocardial Infarction: A Substudy of the CULPRIT-SHOCK Trial. J. Clin. Med., 9.","DOI":"10.3390\/jcm9030860"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Feistritzer, H.-J., Desch, S., Freund, A., Poess, J., Zeymer, U., Ouarrak, T., Schneider, S., De Waha-Thiele, S., Fuernau, G., and Eitel, I. (2020). Prognostic Impact of Active Mechanical Circulatory Support in Cardiogenic Shock Complicating Acute Myocardial Infarction, Results from the Culprit-Shock Trial. J. Clin. Med., 9.","DOI":"10.3390\/jcm9061976"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1056\/NEJMoa1710261","article-title":"PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock","volume":"377","author":"Thiele","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1172\/JCI112160","article-title":"Myocardial reperfusion: A double-edged sword?","volume":"76","author":"Braunwald","year":"1985","journal-title":"J. Clin. Investig."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1161\/CIRCRESAHA.112.300627","article-title":"Current State of Clinical Translation of Cardioprotective Agents for Acute Myocardial Infarction","volume":"113","author":"Kloner","year":"2013","journal-title":"Circ. Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s00395-015-0475-8","article-title":"Cyclosporine A reduces microvascular obstruction and preserves left ventricular function deterioration following myocardial ischemia and reperfusion","volume":"110","author":"Zalewski","year":"2015","journal-title":"Basic Res. Cardiol."},{"key":"ref_62","first-page":"677","article-title":"Platelet activation and microvascular injury in patients with ST-segment elevation myocardial infarction","volume":"70","author":"Zalewski","year":"2012","journal-title":"Kardiol. Pol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.jcmg.2014.06.012","article-title":"Effect of Microvascular Obstruction and Intramyocardial Hemorrhage by CMR on LV Remodeling and Outcomes After Myocardial Infarction: A systematic review and meta-analysis","volume":"7","author":"Hamirani","year":"2014","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1253\/circj.CJ-15-1135","article-title":"Shock Index as a Predictor of Myocardial Damage and Clinical Outcome in ST-Elevation Myocardial Infarction","volume":"80","author":"Reinstadler","year":"2016","journal-title":"Circ. J."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.athoracsur.2012.04.020","article-title":"Surgical Repair of Ventricular Septal Defect After Myocardial Infarction: Outcomes From The Society of Thoracic Surgeons National Database","volume":"94","author":"Arnaoutakis","year":"2012","journal-title":"Ann. Thorac. Surg."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0002-9149(03)00665-9","article-title":"Short- and long-term hemodynamic effects of intra-aortic balloon support in ventricular septal defect complicating acute myocardial infarction","volume":"92","author":"Thiele","year":"2003","journal-title":"Am. J. Cardiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/AC.66.2.2071255","article-title":"Ventricular septal rupture following acute myocardial infarction","volume":"66","author":"Koh","year":"2011","journal-title":"Acta Cardiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/ccd.23271","article-title":"Cardiogenic shock secondary to severe acute ischemic mitral regurgitation managed with an impella 2.5 percutaneous left ventricular assist device","volume":"79","author":"Harmon","year":"2011","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Scherer, C., L\u00fcsebrink, E., Kupka, D., Stocker, T.J., Stark, K., Stremmel, C., Orban, M., Petzold, T., Germayer, A., and Mauthe, K. (2020). Long-Term Clinical Outcome of Cardiogenic Shock Patients Undergoing Impella CP Treatment vs. Standard of Care. J. Clin. Med., 9.","DOI":"10.3390\/jcm9123803"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1002\/ehf2.13202","article-title":"Temporal trends in incidence, causes, use of mechanical circulatory support and mortality in cardiogenic shock","volume":"8","author":"Schrage","year":"2021","journal-title":"ESC Heart Fail."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Asleh, R., and Resar, J.R. (2019). Utilization of Percutaneous Mechanical Circulatory Support Devices in Cardiogenic Shock Complicating Acute Myocardial Infarction and High-Risk Percutaneous Coronary Interventions. J. Clin. Med., 8.","DOI":"10.3390\/jcm8081209"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jacc.2016.10.022","article-title":"Percutaneous Mechanical Circulatory Support Versus Intra-Aortic Balloon Pump in Cardiogenic Shock After Acute Myocardial Infarction","volume":"69","author":"Ouweneel","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.ccl.2013.07.004","article-title":"Mechanical Complications of Acute Myocardial Infarction","volume":"31","author":"Kutty","year":"2013","journal-title":"Cardiol. Clin."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ejcts.2004.04.027","article-title":"Perioperative outcome and long-term survival of surgery for acute post-infarction mitral regurgitation","volume":"26","author":"Chevalier","year":"2004","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.ejcts.2007.12.050","article-title":"Mitral valve surgery in emergency for severe acute regurgitation: Analysis of postoperative results from a multicentre study","volume":"33","author":"Lorusso","year":"2008","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0025-6196(12)61116-1","article-title":"Mitral Valve Operation in Postinfarction Rupture of a Papillary Muscle: Immediate Results and Long-Term Follow-Up of 22 Patients","volume":"67","author":"Kishon","year":"1992","journal-title":"Mayo Clin. Proc."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1161\/CIRCULATIONAHA.107.747949","article-title":"Clinical Outcome After Surgical Correction of Mitral Regurgitation Due to Papillary Muscle Rupture","volume":"118","author":"Russo","year":"2008","journal-title":"Circulation"},{"key":"ref_78","first-page":"830","article-title":"Simultaneous cardiac free wall rupture and ventricular septal rupture following acute myocardial infarction treated with emergency balloon closure","volume":"129","author":"Molek","year":"2019","journal-title":"Pol. Arch. Intern. Med."},{"key":"ref_79","unstructured":"Van Meurs, K., Lally, K.P., and Peek, G. (2005). Economics of ECLS. Extracorporeal Cardiopulmonary Support in Critical Care, ESLO. [3rd ed.]."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/eurheartj\/ehn602","article-title":"A systematic review and meta-analysis of intra-aortic balloon pump therapy in ST-elevation myocardial infarction: Should we change the guidelines?","volume":"30","author":"Sjauw","year":"2008","journal-title":"Eur. Heart J."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1056\/NEJMoa1208410","article-title":"Intraaortic Balloon Support for Myocardial Infarction with Cardiogenic Shock","volume":"367","author":"Thiele","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.resuscitation.2012.01.037","article-title":"Efficacy of veno-arterial extracorporeal membrane oxygenation in acute myocardial infarction with cardiogenic shock","volume":"83","author":"Kim","year":"2012","journal-title":"Resuscitation"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"530.e1","DOI":"10.1016\/j.jcrc.2012.02.012","article-title":"Extracorporeal membrane oxygenation\u2013assisted primary percutaneous coronary intervention may improve survival of patients with acute myocardial infarction complicated by profound cardiogenic shock","volume":"27","author":"Tsao","year":"2012","journal-title":"J. Crit. Care"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ahj.2021.01.002","article-title":"Extracorporeal life support in patients with acute myocardial infarction complicated by cardiogenic shock\u2014Design and rationale of the ECLS-SHOCK trial","volume":"234","author":"Thiele","year":"2021","journal-title":"Am. Heart J."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"469.e1","DOI":"10.1016\/j.ahj.2006.05.031","article-title":"A randomized multicenter clinical study to evaluate the safety and efficacy of the TandemHeart percutaneous ventricular assist device versus conventional therapy with intraaortic balloon pumping for treatment of cardiogenic shock","volume":"152","author":"Burkhoff","year":"2006","journal-title":"Am. Heart J."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1093\/eurheartj\/ehi161","article-title":"Randomized comparison of intra-aortic balloon support with a percutaneous left ventricular assist device in patients with revascularized acute myocardial infarction complicated by cardiogenic shock","volume":"26","author":"Thiele","year":"2005","journal-title":"Eur. Heart J."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.jacc.2008.05.065","article-title":"A Randomized Clinical Trial to Evaluate the Safety and Efficacy of a Percutaneous Left Ventricular Assist Device Versus Intra-Aortic Balloon Pumping for Treatment of Cardiogenic Shock Caused by Myocardial Infarction","volume":"52","author":"Seyfarth","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1097\/CCM.0b013e31821e89b5","article-title":"The Impella 2.5 and 5.0 devices for ST-elevation myocardial infarction patients presenting with severe and profound cardiogenic shock: The Academic Medical Center intensive care unit experience*","volume":"39","author":"Cocchieri","year":"2011","journal-title":"Crit. Care Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1161\/CIRCHEARTFAILURE.112.967224","article-title":"Percutaneous Left-Ventricular Support With the Impella-2.5\u2013Assist Device in Acute Cardiogenic Shock: Results of the Impella-EUROSHOCK-registry","volume":"6","author":"Lauten","year":"2013","journal-title":"Circ. Heart Fail."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1161\/CIRCINTERVENTIONS.112.972711","article-title":"Transcatheter Closure of Post-myocardial Infarction Ventricular Septal Rupture","volume":"6","author":"Assenza","year":"2013","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/eurheartj\/ehn524","article-title":"Immediate primary transcatheter closure of postinfarction ventricular septal defects","volume":"30","author":"Thiele","year":"2008","journal-title":"Eur. Heart J."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1161\/CIRCULATIONAHA.113.005839","article-title":"Percutaneous Closure of Postinfarction Ventricular Septal Defect: In-hospital outcomes and long-term follow-up of UK experience","volume":"129","author":"Calvert","year":"2014","journal-title":"Circulation"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"E137","DOI":"10.1002\/ccd.24960","article-title":"Successful percutaneous mitral valve repair with the mitraclip system of acute mitral regurgitation due to papillary muscle rupture as complication of acute myocardial infarction","volume":"83","author":"Bilge","year":"2014","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1016\/j.athoracsur.2014.09.075","article-title":"MitraClip Implantation After Acute Ischemic Papillary Muscle Rupture in a Patient With Prolonged Cardiogenic Shock","volume":"99","author":"Bahlmann","year":"2015","journal-title":"Ann. Thorac. Surg."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"II-237","DOI":"10.1161\/01.cir.0000089042.80722.7a","article-title":"Midterm Clinical and Echocardiographic Results With Patch Glue Repair of Left Ventricular Free Wall Rupture","volume":"108","author":"Canovas","year":"2003","journal-title":"Circulation"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1253\/jcj.64.312","article-title":"Oozing Type Cardiac Rupture Repaired With Percutaneous Injection of Fibrin-Glue Into the Pericardial Space: Case report","volume":"64","author":"Murata","year":"2000","journal-title":"Jpn. Circ. J."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1007\/s00392-019-01425-x","article-title":"Polyhedral erythrocytes in intracoronary thrombus and their association with reperfusion in myocardial infarction","volume":"108","author":"Zalewski","year":"2019","journal-title":"Clin. Res. Cardiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.ijcard.2003.08.009","article-title":"Detection of microvascular injury by evaluating epicardial blood flow in early reperfusion following primary angioplasty","volume":"96","author":"Zalewski","year":"2004","journal-title":"Int. J. Cardiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.numecd.2013.09.011","article-title":"Polyunsaturated omega-3 fatty acids reduce lipoprotein-associated phospholipase A2 in patients with stable angina","volume":"24","author":"Gajos","year":"2014","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/j.jacc.2010.10.061","article-title":"Intraluminal Thrombus in Facilitated Versus Primary Percutaneous Coronary Intervention: An Angiographic Substudy of the ASSENT-4 PCI (Assessment of the Safety and Efficacy of a New Treatment Strategy with Percutaneous Coronary Intervention) Trial","volume":"57","author":"Zalewski","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ijcard.2009.07.032","article-title":"Evolution of myocardial perfusion during primary angioplasty in spontaneously reperfused infarct-related artery","volume":"147","author":"Zalewski","year":"2011","journal-title":"Int. J. Cardiol."},{"key":"ref_102","first-page":"3839","article-title":"Molecular signature of cardiogenic shock Impact on long-term clinical outcomes and left ventricular function recovery","volume":"41","author":"Rueda","year":"2020","journal-title":"Eur. Heart J."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/24\/5904\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:49:29Z","timestamp":1760168969000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/24\/5904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,16]]},"references-count":102,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["jcm10245904"],"URL":"https:\/\/doi.org\/10.3390\/jcm10245904","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,16]]}}}