{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T19:04:42Z","timestamp":1782241482156,"version":"3.54.5"},"reference-count":25,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Perianal Crohn\u2019s disease is a disabling condition, with little known about anorectal function in healed\/inactive perianal Crohn\u2019s disease; Aim: To evaluate anorectal function in a cohort of patients with treated\/healed perianal Crohn\u2019s disease; Methods: Prospective cohort study, including high-resolution anorectal manometry, balloon expulsion test, and 3D-endoanal ultrasound in all patients; Results: Of the 16 patients studied (mean age \u00b1 SD, 42 \u00b1 13 years), 12 (75%) were men. A laceration of the internal anal sphincter and\/or anal scarring was seen in nine (56%) patients; there was no laceration of the external anal sphincter. Five (56%) of these nine patients had never experienced faecal incontinence. All had normal anal resting and squeeze pressures. Manometry suggested dyssynergia in 11 (69%) patients, with only one (6%) fulfilling the criteria for obstructed defecation. Hyposensitivity for at least one sensory parameter was seen in 11 (69%) patients and hypersensitivity in five (31%) patients; Conclusions: This study detected sphincter abnormalities in more than half of patients, many of whom were asymptomatic. Alterations in rectal sensation were frequently seen, more commonly with rectal hyposensitivity. Trial registration: ClinicalTrials.gov (NCT03819257).<\/jats:p>","DOI":"10.3390\/jcm10245909","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T11:27:36Z","timestamp":1639654056000},"page":"5909","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of Anorectal Function in Perianal Crohn\u2019s Disease: A Pilot Study"],"prefix":"10.3390","volume":"10","author":[{"given":"Andreia","family":"Albuquerque","sequence":"first","affiliation":[{"name":"Gastroenterology Department, St. James\u2019s University Hospital, Leeds LS9 7TF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Casey","sequence":"additional","affiliation":[{"name":"GI Physiology Department, St. James\u2019s University Hospital, Leeds LS9 7TF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Fairlamb","sequence":"additional","affiliation":[{"name":"GI Physiology Department, St. James\u2019s University Hospital, Leeds LS9 7TF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5351-0229","authenticated-orcid":false,"given":"Lesley A.","family":"Houghton","sequence":"additional","affiliation":[{"name":"Leeds Institute of Medical Research, St. James\u2019s University Hospital, Leeds LS9 7TF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Selinger","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, St. James\u2019s University Hospital, Leeds LS9 7TF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1136\/gutjnl-2017-314918","article-title":"Modern management of perianal fistulas in Crohn\u2019s disease: Future directions","volume":"67","author":"Kotze","year":"2018","journal-title":"Gut"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/ecco-jcc\/jjw169","article-title":"3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn\u2019s Disease 2016: Part 2: Surgical Management and Special Situations","volume":"11","author":"Gionchetti","year":"2017","journal-title":"J. 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