{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:49:29Z","timestamp":1790117369731,"version":"4.0.1"},"reference-count":110,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:00:00Z","timestamp":1639699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Pterygium is a benign fibrovascular lesion of the bulbar conjunctiva with frequent involvement of the corneal limbus. Its pathogenesis has been mainly attributed to sun exposure to ultraviolet-B radiation. Obtained evidence has shown that it is a complex and multifactorial process which involves multiple mechanisms such as oxidative stress, dysregulation of cell cycle checkpoints, induction of inflammatory mediators and growth factors, angiogenic stimulation, extracellular matrix (ECM) disorders, and, most likely, viruses and hereditary changes. In this review, we aim to collect all authors\u2019 experiences and our own, with respect to the study of fibroelastic ECM of pterygium. Collagen and elastin are intrinsic indicators of physiological and pathological states. Here, we focus on an in-depth analysis of collagen (types I and III), as well as the main constituents of elastic fibers (tropoelastin (TE), fibrillins (FBNs), and fibulins (FBLNs)) and the enzymes (lysyl oxidases (LOXs)) that carry out their assembly or crosslinking. All the studies established that changes in the fibroelastic ECM occur in pterygium, based on the following facts: An increase in the synthesis and deposition of an immature form of collagen type III, which showed the process of tissue remodeling. An increase in protein levels in most of the constituents necessary for the development of elastic fibers, except FBLN4, whose biological roles are critical in the binding of the enzyme LOX, as well as FBN1 for the development of stable elastin. There was gene overexpression of TE, FBN1, FBLN5, and LOXL1, while the expression of LOX and FBLN2 and -4 remained stable. In conclusion, collagen and elastin, as well as several constituents involved in elastic fiber assembly are overexpressed in human pterygium, thus, supporting the hypothesis that there is dysregulation in the synthesis and crosslinking of the fibroelastic component, constituting an important pathogenetic mechanism for the development of the disease.<\/jats:p>","DOI":"10.3390\/jcm10245930","type":"journal-article","created":{"date-parts":[[2021,12,19]],"date-time":"2021-12-19T20:37:27Z","timestamp":1639946247000},"page":"5930","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The Role of the Stromal Extracellular Matrix in the Development of Pterygium Pathology: An Update"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6361-3689","authenticated-orcid":false,"given":"Javier","family":"Mart\u00edn-L\u00f3pez","sequence":"first","affiliation":[{"name":"Departamento de Medicina y Especialidades M\u00e9dicas, Facultad de Medicina y Ciencias de la Salud, Universidad de Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8267-4014","authenticated-orcid":false,"given":"Consuelo","family":"P\u00e9rez-Rico","sequence":"additional","affiliation":[{"name":"Departamento de Cirug\u00eda, Ciencias M\u00e9dicas y Sociales, Facultad de Medicina y Ciencias de la Salud, Universidad de Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3118-0564","authenticated-orcid":false,"given":"Selma","family":"Benito-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Departamento de Medicina y Especialidades M\u00e9dicas, Facultad de Medicina y Ciencias de la Salud, Universidad de Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Spain"},{"name":"Biomedical Networking Research Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain"},{"name":"Ram\u00f3n y Cajal Health Research Institute (IRYCIS), 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5061-1526","authenticated-orcid":false,"given":"B\u00e1rbara","family":"P\u00e9rez-K\u00f6hler","sequence":"additional","affiliation":[{"name":"Departamento de Medicina y Especialidades M\u00e9dicas, Facultad de Medicina y Ciencias de la Salud, Universidad de Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Spain"},{"name":"Biomedical Networking Research Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain"},{"name":"Ram\u00f3n y Cajal Health Research Institute (IRYCIS), 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2419-2476","authenticated-orcid":false,"given":"Julia","family":"Buj\u00e1n","sequence":"additional","affiliation":[{"name":"Departamento de Medicina y Especialidades M\u00e9dicas, Facultad de Medicina y Ciencias de la Salud, Universidad de Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Spain"},{"name":"Ram\u00f3n y Cajal Health Research Institute (IRYCIS), 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1623-4384","authenticated-orcid":false,"given":"Gemma","family":"Pascual","sequence":"additional","affiliation":[{"name":"Departamento de Medicina y Especialidades M\u00e9dicas, Facultad de Medicina y Ciencias de la Salud, Universidad de Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Spain"},{"name":"Biomedical Networking Research Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), 28029 Madrid, Spain"},{"name":"Ram\u00f3n y Cajal Health Research Institute (IRYCIS), 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1001\/archopht.1997.01100160405001","article-title":"Effect of pterygium morphology on pterygium recurrence in a controlled trial comparing conjunctival autografting with bare sclera excision","volume":"115","author":"Tan","year":"1997","journal-title":"Arch. 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