{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:44:56Z","timestamp":1787237096162,"version":"build-2736575974"},"reference-count":22,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Introduction: Lichen planus (LP) is a chronic autoimmune disease that affects skin, oral and genital mucosa, and other sites. Basic difficulties in assessment of LP are multitude of disease forms and diverse locations of lesions. Moreover, there is lack of objective and consolidated tool for assessment of disease severity and LP progression. Objective: The aim of the study was to develop a valid evaluation tool of LP severity, which will enable disease assessment in a repetitive way. Materials and methods: A combined tool called Lichen Planus Activity and Damage Index (LiPADI) was developed to assess the severity of LP skin, mucosal, and nail lesions as well as hair loss\/scaring alopecia to provide an integrative scoring for LP activity and damage caused by the disease. Skin lesions were assessed in nine locations: scalp, face, chest, abdomen, back and buttocks, arms, hands, legs, and feet. The assessment of lesion activity included erythema, hypertrophy, and scaling, while the damage was reflected by the assessment of hyperpigmentation and scaring\/atrophy. In addition, mucosal lesions, nail abnormalities, hair loss, and scarring alopecia were evaluated as well. LiPADI scoring was compared with quality of life assessed with the Dermatology Life Quality Index, EQ-5D calculator, pain and pruritus intensity assessed with the Numerical Rating Scale as well as with the patient and physician global assessment. Results: Our results show that LiPADI well reflects the LP patient\u2019s clinical condition. The obtained results were in line with other indicators assessed. In addition, it was possible to evaluate patients with various forms and locations of LP, what indicates its versatility. Conclusions: LiPADI seems to be a useful tool for measurement the severity of the LP and its progress over time, which could help to monitor the effectiveness of the patients\u2019 treatment.<\/jats:p>","DOI":"10.3390\/jcm11010023","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T10:24:52Z","timestamp":1640168692000},"page":"23","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Lichen Planus Activity and Damage Index (LiPADI)\u2013Creation of the Questionnaire"],"prefix":"10.3390","volume":"11","author":[{"given":"Katarzyna","family":"St\u0119pie\u0144","sequence":"first","affiliation":[{"name":"Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University, 35-055 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"\u017babska","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University, 35-055 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5622-7330","authenticated-orcid":false,"given":"Mansur","family":"Rahnama-Hezavah","sequence":"additional","affiliation":[{"name":"Chair and Department of Dental Surgery, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5573-1754","authenticated-orcid":false,"given":"Adam","family":"Reich","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University, 35-055 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4103\/0019-5154.156315","article-title":"Oral Lichen Planus: An Update on Etiology, Pathogenesis, Clinical Presentation, Diagnosis and Management","volume":"60","author":"Gupta","year":"2015","journal-title":"Indian J. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ijwd.2015.04.001","article-title":"Update on Lichen Planus and Its Clinical Variants","volume":"1","author":"Weston","year":"2015","journal-title":"Int. J. Womens Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4103\/0019-5154.131389","article-title":"Lichen Planus: A Clinical and Immuno-Histological Analysis","volume":"59","author":"Chhabra","year":"2014","journal-title":"Indian J. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2147\/CCID.S137870","article-title":"Therapeutic Management of Classic Lichen Planopilaris: A Systematic Review. Clin. Cosmet","volume":"11","author":"Errichetti","year":"2018","journal-title":"Investig. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.det.2020.12.002","article-title":"Review of Nail Lichen Planus","volume":"39","author":"Gupta","year":"2021","journal-title":"Dermatol. Clin."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4103\/ijstd.IJSTD_45_19","article-title":"Genital Lichen Planus: An Underrecognized Entity","volume":"40","author":"Khurana","year":"2019","journal-title":"Indian J. Sex. Transm. Dis. AIDS"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Amsellem, J., Skayem, C., Duong, T., Bagot, M., Fou\u00e9r\u00e9, S., and Dauendorffer, J. (2021). Male Genital Lichen Planus: A Retrospective Study of 89 Cases. Ann. Dermatol. Venereol., Available online: https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0151963821000569?via%3Dihub.","DOI":"10.1016\/j.annder.2021.04.007"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000472711","article-title":"Assessment of Intra- and Inter-Rater Reliability of Three Methods for Measuring Atopic Dermatitis Severity: EASI, Objective SCORAD, and IGA","volume":"233","author":"Reich","year":"2017","journal-title":"Dermatology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"851","DOI":"10.17219\/acem\/69804","article-title":"The Reliability of Three Psoriasis Assessment Tools: Psoriasis Area and Severity Index, Body Surface Area and Physician Global Assessment","volume":"26","author":"Reich","year":"2017","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/rheumatology\/kep361","article-title":"Development and Initial Validation of the Localized Scleroderma Skin Damage Index and Physician Global Assessment of Disease Damage: A Proof-of-Concept Study","volume":"49","author":"Arkachaisri","year":"2010","journal-title":"Rheumatology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1365-2230.1994.tb01167.x","article-title":"Dermatology Life Quality Index (DLQI)\u2014A Simple Practical Measure for Routine Clinical Use","volume":"19","author":"Finlay","year":"1994","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"614005","DOI":"10.3389\/fmed.2020.614005","article-title":"The 12-Item Pruritus Severity Scale\u2014Determining the Severity Bands","volume":"7","author":"Reich","year":"2020","journal-title":"Front. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"759","DOI":"10.2340\/00015555-2642","article-title":"Tailoring the Cut-Off Values of the Visual Analogue Scale and Numeric Rating Scale in Itch Assessment","volume":"97","author":"Reich","year":"2017","journal-title":"Acta Derm. Venereol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1529-8019.2007.00117.x","article-title":"Development of the CLASI as an Outcome Instrument for Cutaneous Lupus Erythematosus","volume":"20","author":"Albrecht","year":"2007","journal-title":"Dermatol. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"742826","DOI":"10.1155\/2014\/742826","article-title":"Cutaneous and Mucosal Lichen Planus: A Comprehensive Review of Clinical Subtypes, Risk Factors, Diagnosis, and Prognosis","volume":"2014","author":"Gorouhi","year":"2014","journal-title":"Sci. World J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e199","DOI":"10.4317\/medoral.20524","article-title":"Disease Scoring Systems for Oral Lichen Planus: A Critical Appraisal","volume":"20","author":"Wang","year":"2015","journal-title":"Med. Oral Patol. Oral Cir. Bucal."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.1600-0714.1992.tb00974.x","article-title":"Relative Efficacy of Fluocinolone Acetonide Compared with Triamcinolone Acetonide in Treatment of Oral Lichen Planus","volume":"21","author":"Thongprasom","year":"1992","journal-title":"J. Oral Pathol. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jaad.2009.08.054","article-title":"Hydroxychloroquine and Lichen Planopilaris: Efficacy and Introduction of Lichen Planopilaris Activity Index Scoring System","volume":"62","author":"Chiang","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/bjd.14445","article-title":"Frontal Fibrosing Alopecia Severity Index (FFASI): A Validated Scoring System for Assessing Frontal Fibrosing Alopecia","volume":"175","author":"Holmes","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jaad.2017.09.034","article-title":"Development and Validation of the Frontal Fibrosing Alopecia Severity Score","volume":"78","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e140","DOI":"10.1111\/ijd.14459","article-title":"Proposition of a Comprehensive Score to Assess the Disease Severity and Activity of Cutaneous Lichen Planus","volume":"58","author":"Bishnoi","year":"2019","journal-title":"Int. J. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4103\/ijdvl.IJDVL_650_17","article-title":"Lichen Planus Severity Index: A New, Valid Scoring System to Assess the Severity of Cutaneous Lichen Planus","volume":"86","author":"Kaur","year":"2020","journal-title":"Indian J. Dermatol. Venereol. Leprol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/1\/23\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:51:01Z","timestamp":1760169061000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/1\/23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,22]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["jcm11010023"],"URL":"https:\/\/doi.org\/10.3390\/jcm11010023","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,22]]}}}