{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:40:06Z","timestamp":1760236806273,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: Recent data shed light on the association between atopic disorders (ADs) (atopic dermatitis, allergic asthma, allergic rhinitis) and spondyloarthropathies (SpAs), underpinning the critical role of T helper (Th)1-Th17\/Th2-T regulatory cells disbalance. We evaluated the prevalence of AD in axial SpAs (axSpAs) and psoriatic arthritis (PsA) and explored the potential association between atopic status, disease-related parameters, and biological therapy. (2) Methods: A monocentric, retrospective study was conducted that enrolled 200 patients taking biologics. Demographics, disease, and drug-related variables, along with a screening questionnaire focused on Ads, were systematically collected. (3) Results: Overall, 51 patients (25.5%) had atopy\u2014namely, 24.4% of axSpA and 28% of PsA, with a higher frequency of rhinitis (43%) vs. atopic dermatitis (37.2%) or asthma (21.5%). We failed to demonstrate any statistically significant difference in demographics, SpA-related parameters excepting concomitant inflammatory bowel disease, and biologic drug exposure in patients with and without atopy (p &gt; 0.05). However, significantly more non-atopic patients need only one TNF inhibitor (54%) vs. atopic patients (28%) (p &lt; 0.05) to control active SpA. (4) Conclusions: We successfully demonstrated that AD is associated with one out of four SpA. Irrespective of the SpA subtype, atopic patients require more frequent switching among biologics, as significantly more non-atopic patients remain on their first anti-TNF.<\/jats:p>","DOI":"10.3390\/jcm11010055","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T10:16:18Z","timestamp":1640254578000},"page":"55","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Prevalence of Atopy in Biologically Treated Spondyloarthropathies: A Retrospective Study of 200 Patients"],"prefix":"10.3390","volume":"11","author":[{"given":"Georgiana","family":"Strugariu","sequence":"first","affiliation":[{"name":"Rheumatology Department, University of Medicine and Pharmacy \u201cGrigore T Popa\u201d, 700115 Ia\u0219i, Romania"},{"name":"2nd Rheumatology Department, Clinical Rehabilitation Hospital, 700664 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Pom\u00eerleanu","sequence":"additional","affiliation":[{"name":"Rheumatology Department, University of Medicine and Pharmacy \u201cGrigore T Popa\u201d, 700115 Ia\u0219i, Romania"},{"name":"2nd Rheumatology Department, Clinical Rehabilitation Hospital, 700664 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Codru\u021ba","family":"Bran","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biological Sciences, \u0218tefan cel Mare University of Suceava, 720229 Suceava, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Costea","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Biological Sciences, \u0218tefan cel Mare University of Suceava, 720229 Suceava, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Vicovan","sequence":"additional","affiliation":[{"name":"Department of Morpho-Functional Sciences II\u2014Pharmacology and Clinical Pharmacology, University of Medicine and Pharmacy \u201cGrigore T Popa\u201d, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Tatarciuc","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Geriatrics, University of Medicine and Pharmacy \u201cGrigore T Popa\u201d, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"E\u0219anu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Geriatrics, University of Medicine and Pharmacy \u201cGrigore T Popa\u201d, 700115 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugen","family":"Ancu\u021ba","sequence":"additional","affiliation":[{"name":"Research Department, \u201cElena Doamna\u201d Clinical Hospital, 700398 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodica","family":"Chirieac","sequence":"additional","affiliation":[{"name":"SANOCARE Medical and Research Center, 700259 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1777-8121","authenticated-orcid":false,"given":"Codrina","family":"Ancu\u021ba","sequence":"additional","affiliation":[{"name":"Rheumatology Department, University of Medicine and Pharmacy \u201cGrigore T Popa\u201d, 700115 Ia\u0219i, Romania"},{"name":"2nd Rheumatology Department, Clinical Rehabilitation Hospital, 700664 Ia\u0219i, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15013","DOI":"10.1038\/nrdp.2015.13","article-title":"Axial spondyloarthritis","volume":"1","author":"Sieper","year":"2015","journal-title":"Nat. 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