{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:40:10Z","timestamp":1760236810858,"version":"build-2065373602"},"reference-count":41,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T00:00:00Z","timestamp":1640304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002738","name":"Assistance Publique - H\u00f4pitaux de Paris","doi-asserted-by":"publisher","award":["the study was funded by a grant from the French \u201cProgramme Hospitalier de Recherche Clinique Inter-r\u00e9gional\u201d \u2013 PHRC-IR 2011"],"award-info":[{"award-number":["the study was funded by a grant from the French \u201cProgramme Hospitalier de Recherche Clinique Inter-r\u00e9gional\u201d \u2013 PHRC-IR 2011"]}],"id":[{"id":"10.13039\/501100002738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: osteopathic manipulation of the sphenopalatine ganglia (SPG) blocks the action of postganglionic sensory fibres. This neuromodulation can reduce nasal obstruction and enhance upper airway stability. We investigated the manipulation of the SPG in 31 patients with obstructive sleep apnoea syndrome (OSAS); (2) Methods: Randomised, controlled, double-blind, crossover study. Participants received active (AM), then sham manipulation (SM), or vice versa. The primary endpoint was apnoea-hypopnoea index (AHI). Secondary endpoints were variation of nasal obstruction evaluated by peak nasal inspiratory flow (PNIF) and upper airways stability evaluated by awake critical closing pressure [awake Pcrit]), at 30 min and 24 h. Schirmer\u2019s test and pain were assessed immediately post-manipulation. Tactile\/gustatory\/olfactory\/auditory\/nociceptive\/visual sensations were recorded. Adverse events were collected throughout. (3) Results: SPG manipulation did not reduce AHI (p = 0.670). PNIF increased post-AM but not post-SM at 30 min (AM-SM: 18 [10; 38] L\/min, p = 0.0001) and 24 h (23 [10; 30] L\/min, p = 0.001). There was no significant difference on awake Pcrit (AM-SM) at 30 min or 24 h). Sensations were more commonly reported post-AM (100% of patients) than post-SM (37%). Few adverse events and no serious adverse events were reported. (4) Conclusions: SPG manipulation is not supported as a treatment for OSAS but reduced nasal obstruction. This effect remains to be confirmed in a larger sample before using this approach to reduce nasal congestion in CPAP-treated patients or in mild OSAS.<\/jats:p>","DOI":"10.3390\/jcm11010099","type":"journal-article","created":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T01:00:54Z","timestamp":1640566854000},"page":"99","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Osteopathic Manipulation of the Sphenopalatine Ganglia Versus Sham Manipulation, in Obstructive Sleep Apnoea Syndrom: A Randomised Controlled Trial"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5444-9223","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Attali","sequence":"first","affiliation":[{"name":"UMRS1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, INSERM, Sorbonne Universit\u00e9, 75005 Paris, France"},{"name":"AP-HP, D\u00e9partement R3S, Service des Pathologies du Sommeil, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Jacq","sequence":"additional","affiliation":[{"name":"UMRS1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, INSERM, Sorbonne Universit\u00e9, 75005 Paris, France"},{"name":"AP-HP, D\u00e9partement R3S, Service des Pathologies du Sommeil, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine","family":"Martin","sequence":"additional","affiliation":[{"name":"AP-HP, Unit\u00e9 de Recherche Clinique PSL-CFX, H\u00f4pital Piti\u00e9 Salp\u00eatri\u00e8re, INSERM, CIC-1901, Sorbonne Universit\u00e9, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Arnulf","sequence":"additional","affiliation":[{"name":"AP-HP, D\u00e9partement R3S, Service des Pathologies du Sommeil, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, 75013 Paris, France"},{"name":"Institut du Cerveau-Paris Brain Institute-ICM, INSERM, CNRS, Sorbonne Universit\u00e9, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Similowski","sequence":"additional","affiliation":[{"name":"UMRS1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, INSERM, Sorbonne Universit\u00e9, 75005 Paris, France"},{"name":"AP-HP, D\u00e9partement R3S, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Sorbonne Universit\u00e9, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15015","DOI":"10.1038\/nrdp.2015.15","article-title":"Obstructive sleep apnoea syndrome","volume":"1","author":"Levy","year":"2015","journal-title":"Nat. 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