{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:40:28Z","timestamp":1760236828859,"version":"build-2065373602"},"reference-count":19,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,25]],"date-time":"2021-12-25T00:00:00Z","timestamp":1640390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The diagnosis of organizing pneumonia (OP) often requires histological confirmation. The aim of this retrospective study was to evaluate the diagnostic yield and complication rate of radial endobronchial ultrasound (r-EBUS) for OP. Methods: All patients who had r-EBUS as a first diagnostic procedure for a peripheral pulmonary lesion at Rouen University Hospital, France, between April 2008 and December 2020 were included. Cases without a final diagnosis of OP or follow-up were excluded. Patients, lesions, and r-EBUS characteristics were retrospectively analyzed. Results: 2735 r-EBUS procedures were performed, and 33 cases with final OP could be analyzed. Procedures were performed under local anesthesia in 28\/33 cases (85%). Among the 33 final OP cases, 17 were considered cryptogenic, and 16 secondary. The lesions were patchy alveolar opacities in 23 cases (70%), masses or pulmonary nodules in 8 cases (24%), and diffuse infiltrative opacities in 2 cases (6%). A bronchus sign on CT scan was found in all cases. In 22 cases (67%), a histopathological diagnosis was obtained from the r-EBUS samples. In 4 cases (12%), histopathological diagnosis was made by surgery, and in 7 cases (21%) the diagnosis was made based on clinical, radiological, and evolution features. An ultrasound image was found in 100% (22\/22) of cases in the r-EBUS positive (r-EBUS+) group vs. 60% (6\/10) in the r-EBUS negative (r-EBUS-) group, respectively (p &lt; 0.002). The diagnostic yield of r-EBUS for OP was 67% and increased to 79% (22\/28) when an ultrasound image was obtained. The median time between CT scan and r-EBUS procedure was 14 days (3\u201394): 11.5 days in the r-EBUS+ group and 22 days in the r-EBUS- group (p &lt; 0.0001). No severe complications were reported. Conclusion: r-EBUS, when performed shortly after a CT scan showing a bronchus sign, is an efficient and safe technique for OP diagnosis.<\/jats:p>","DOI":"10.3390\/jcm11010104","type":"journal-article","created":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T01:00:54Z","timestamp":1640566854000},"page":"104","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Virtual Bronchoscopy Planner and Radial-EBUS Guided Biopsy for Organizing Pneumonia Diagnosis"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7871-0887","authenticated-orcid":false,"given":"Samy","family":"Lachkar","sequence":"first","affiliation":[{"name":"Department of Pulmonology, Thoracic Oncology and Respiratory Intensive Care & CIC-CRB 1404, Rouen University Hospital, F-76000 Rouen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Sala\u00fcn","sequence":"additional","affiliation":[{"name":"EA4108 LITIS Lab, CHU Rouen, Department of Pneumology and Inserm CIC-CRB 1404, UNIROUEN, Normandie Univ, F-76000 Rouen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4647-5066","authenticated-orcid":false,"given":"Loic","family":"Perrot","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Thoracic Oncology and Respiratory Intensive Care & CIC-CRB 1404, Rouen University Hospital, F-76000 Rouen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Gervereau","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Thoracic Oncology and Respiratory Intensive Care & CIC-CRB 1404, Rouen University Hospital, F-76000 Rouen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marielle","family":"De Marchi","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Thoracic Oncology and Respiratory Intensive Care & CIC-CRB 1404, Rouen University Hospital, F-76000 Rouen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurvan","family":"Le Bouar","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Thoracic Oncology and Respiratory Intensive Care & CIC-CRB 1404, Rouen University Hospital, F-76000 Rouen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene","family":"Morisse-Pradier","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Thoracic Oncology and Respiratory Intensive Care & CIC-CRB 1404, Rouen University Hospital, F-76000 Rouen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephane","family":"Dominique","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Thoracic Oncology and Respiratory Intensive Care & CIC-CRB 1404, Rouen University Hospital, F-76000 Rouen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8779-586X","authenticated-orcid":false,"given":"Nicolas","family":"Piton","sequence":"additional","affiliation":[{"name":"Department of Cytology and Pathology, Rouen University Hospital, F-76000 Rouen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8166-7303","authenticated-orcid":false,"given":"Florian","family":"Guisier","sequence":"additional","affiliation":[{"name":"EA4108 LITIS Lab, CHU Rouen, Department of Pneumology and Inserm CIC-CRB 1404, UNIROUEN, Normandie Univ, F-76000 Rouen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Thiberville","sequence":"additional","affiliation":[{"name":"EA4108 LITIS Lab, CHU Rouen, Department of Pneumology and Inserm CIC-CRB 1404, UNIROUEN, Normandie Univ, F-76000 Rouen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1055\/s-0036-1582013","article-title":"Many faces of bronchiolitis and organizing pneumonia","volume":"37","author":"Cordier","year":"2016","journal-title":"Semin. 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