{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:41:05Z","timestamp":1760236865593,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T00:00:00Z","timestamp":1640736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wroc\u0142aw Medical University","award":["STM.C240.17.037","SUB.C240.21.036"],"award-info":[{"award-number":["STM.C240.17.037","SUB.C240.21.036"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Purpose: Little is known about short-term changes in intraocular pressure (IOP) following minimally invasive glaucoma surgeries, such as post-XEN GelStent implantation. Although the importance of corneal biomechanics in glaucoma diagnostics has been reported, little work has been conducted on postoperative description of changes when the structure of the anterior segment is altered. The aim of presented study was to evaluate the changes in the biomechanical parameters of the anterior segment of the post-XEN GelStent implantation eyes. Patients and Methods: This investigator-initiated, open-label, prospective, single-center study recruited patients. Patients with primary open-angle glaucoma (POAG) after XEN GelStent implantation versus matched POAG controls (considered as control group\/CG) treated pharmacologically were screened. Water loading was conducted using 10 mL of water per kilogram of body weight for \u22645 min. Goldmann applanation tonometry (GAT), corneal hysteresis (CH), and corneal resistance factor (CRF) were performed before water loading and after every 15 min up to 1 h. Results: The water drinking test (WDT) was positive in 3.7% (1 out of 27) of patients in the post-XEN group compared with 22.7% (5 out of 22) of patients in the control group (CG; p &lt; 0.05). Mean fluctuations in GAT during the WDT were higher in the CG group (3.6 \u00b1 2.5 mmHg vs. 2.9 \u00b1 1.3 mmHg, p &lt; 0.001). CRF and CH changed significantly only in the post-XEN group. The mean peak of CH and CRF occurred at 15 and 30 min of the test in the post-XEN group (p = 0.001). Conclusion: WDT is important to assess the ability of compensation mechanisms to reduce fluctuations in IOP after water upload. The relationship between biomechanics of the anterior segment and glaucoma may have substantial impact on surgical outcome evaluation.<\/jats:p>","DOI":"10.3390\/jcm11010175","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T08:12:15Z","timestamp":1640765535000},"page":"175","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Short-Time Changes of Intraocular Pressure and Biomechanics of the Anterior Segment of the Eye during Water Drinking Test in Patients with XEN GelStent"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1099-4876","authenticated-orcid":false,"given":"Joanna","family":"Prze\u017adziecka-Do\u0142yk","sequence":"first","affiliation":[{"name":"Department of Optics and Photonics, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland"},{"name":"Department of Ophthalmology, Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Wa\u0142ek","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0449-789X","authenticated-orcid":false,"given":"Agnieszka","family":"J\u00f3\u017awik","sequence":"additional","affiliation":[{"name":"Department of Optics and Photonics, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwona","family":"Helemejko","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Asejczyk-Widlicka","sequence":"additional","affiliation":[{"name":"Department of Optics and Photonics, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Misiuk-Hoj\u0142o","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1590\/S1807-59322008000400004","article-title":"Correlation between the water drinking test and modified diurnal tension curve in untreated glaucomatous eyes","volume":"63","author":"Susanna","year":"2008","journal-title":"Clinics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1136\/bjo.2005.070649","article-title":"The relation between intraocular pressure peak in the water drinking test and visual field progression in glaucoma","volume":"89","author":"Susanna","year":"2005","journal-title":"Br. 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