{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T23:02:00Z","timestamp":1776207720109,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: To date, there are no data regarding the systematic application of Point-of-Care Lung Ultrasound (PoC-LUS) in children with Multisystem Inflammatory Syndrome in Children (MIS-C). The main aim of this study is to show the role of Point-of-Care Lung Ultrasound as an additional aid in the diagnosis of COVID-19-related Multisystem Inflammatory Syndrome in Children (MIS-C). Methods: Between April 2020 and April 2021, patients aged 0\u201318 years referred to our emergency department for fever, and later hospitalized without a specific diagnosis, underwent PoC-LUS. Ultrasound images of patients with a final diagnosis of MIS-C were retrospectively evaluated. Results: Ten patients were enrolled. All were described to have pleural irregularities and B-lines. In particular: 8\/10 children presented with isolated B-lines in at least half of the lung areas of interest; 8\/10 presented with multiple B-lines and 3\/8 had them in at least 50% of lung areas; 5\/10 had a white lung appearance in at least one lung area and 1\/5 had them in half of the areas of interest. Pleural effusion was described in 9\/10. Conclusions: During the ongoing COVID-19 pandemic, we suggest performing PoC-LUS in febrile patients with high levels of inflammatory indices and clinical suspicion of MIS-C, or without a certain diagnosis; the finding of many B-lines and pleural effusion would support the diagnosis of a systemic inflammatory disease.<\/jats:p>","DOI":"10.3390\/jcm11010234","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T01:14:02Z","timestamp":1641518042000},"page":"234","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Role of Lung Ultrasound in Diagnosing COVID-19-Related Multisystemic Inflammatory Disease: A Preliminary Experience"],"prefix":"10.3390","volume":"11","author":[{"given":"Anna Maria","family":"Musolino","sequence":"first","affiliation":[{"name":"Pediatric Emergency, Department of Emergency and General Pediatrics, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00100 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Boccuzzi","sequence":"additional","affiliation":[{"name":"Pediatric Emergency, Department of Emergency and General Pediatrics, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00100 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-2639","authenticated-orcid":false,"given":"Danilo","family":"Buonsenso","sequence":"additional","affiliation":[{"name":"Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00100 Rome, Italy"},{"name":"Global Health Research Institute, Universit\u00e0 Cattolica del Sacro Cuore, 00100 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2507-8886","authenticated-orcid":false,"given":"Maria Chiara","family":"Supino","sequence":"additional","affiliation":[{"name":"Pediatric Emergency, Department of Emergency and General Pediatrics, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00100 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Alessia","family":"Mesturino","sequence":"additional","affiliation":[{"name":"Pediatric Emergency, Department of Emergency and General Pediatrics, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00100 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenio","family":"Pitaro","sequence":"additional","affiliation":[{"name":"Academic Department of Pediatrics, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00100 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Ferro","sequence":"additional","affiliation":[{"name":"Pediatric Emergency, Department of Emergency and General Pediatrics, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00100 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Nacca","sequence":"additional","affiliation":[{"name":"Pediatric Emergency, Department of Emergency and General Pediatrics, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00100 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Sinibaldi","sequence":"additional","affiliation":[{"name":"Pediatric Unit, Department of Emergency and General Pediatrics, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00050 Palidoro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Palma","sequence":"additional","affiliation":[{"name":"Clinical Immunology and Vaccinology Unit, Research Unit in Clinical Immunology and Vaccinology, Academic Department of Pediatrics, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00100 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9120-0424","authenticated-orcid":false,"given":"Alberto","family":"Villani","sequence":"additional","affiliation":[{"name":"Department of Emergency and General Pediatrics, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00100 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0158-4760","authenticated-orcid":false,"given":"Paolo","family":"Tom\u00e0","sequence":"additional","affiliation":[{"name":"Department of Imaging, Bambino Ges\u00f9 Children\u2019s Hospital, IRCCS, 00100 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1002\/jum.15284","article-title":"Is there a role for lung ultrasound during the COVID-19 pandemic?","volume":"39","author":"Soldati","year":"2020","journal-title":"J. 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