{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:17:30Z","timestamp":1789139850517,"version":"build-2803163510"},"reference-count":39,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Individuals with primary hyperparathyroidism (PHPT) have reduced bone mineral density (BMD) according to dual X-ray absorptiometry at cortical sites, with relative sparing of trabecular BMD. However, fracture risk is increased at all sites. Trabecular bone score (TBS) may more accurately describe their bone quality and fracture risk. This study compared how BMD and TBS describe bone quality in PHPT. We conducted a retrospective cross-sectional study with a longitudinal component, of adults with PHPT, admitted to a tertiary hospital in Australia over ten years. The primary outcome was the TBS at the lumbar spine, compared to BMD, to describe bone quality and predict fractures. Secondary outcomes compared changes in TBS after parathyroidectomy. Of 68 included individuals, the mean age was 65.3 years, and 79% were female. Mean \u00b1 SD T-scores were \u22121.51 \u00b1 1.63 at lumbar spine and mean TBS was 1.19 \u00b1 0.12. Only 20.6% of individuals had lumbar spine BMD indicative of osteoporosis, while 57.4% of TBS were \u22641.20, indicating degraded architecture. There was a trend towards improved fracture prediction using TBS compared to BMD which did not reach statistical significance. Comparison of 15 individuals following parathyroidectomy showed no improvement in TBS.<\/jats:p>","DOI":"10.3390\/jcm11020330","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T17:42:25Z","timestamp":1641836545000},"page":"330","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Bone Mineral Density Compared to Trabecular Bone Score in Primary Hyperparathyroidism"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8419-7987","authenticated-orcid":false,"given":"Alicia R.","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetes, Western Health, Furlong Road, St Albans, VIC 3021, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6534-2277","authenticated-orcid":false,"given":"Koen","family":"Simons","sequence":"additional","affiliation":[{"name":"Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Bouverie Street, Melbourne, VIC 3010, Australia"},{"name":"Office for Research, Western Health, Furlong Road, St Albans, VIC 3021, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Harvey","sequence":"additional","affiliation":[{"name":"Department of Medicine\u2014Western Campus, The University of Melbourne, Furlong Road, St Albans, VIC 3021, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Grill","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes, Western Health, Furlong Road, St Albans, VIC 3021, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1359\/jbmr.1997.12.5.856","article-title":"Primary Hyperparathyroidism: Still Evolving?","volume":"12","author":"Silverberg","year":"1997","journal-title":"J. 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