{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:53:22Z","timestamp":1784357602078,"version":"3.55.0"},"reference-count":92,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish research council","doi-asserted-by":"publisher","award":["2018-02500_VR"],"award-info":[{"award-number":["2018-02500_VR"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish Brain Foundation","award":["FO2020-0147, FO2019-0190, FO2018-0166,"],"award-info":[{"award-number":["FO2020-0147, FO2019-0190, FO2018-0166,"]}]},{"name":"Swedish center for sports medicine","award":["P2019-0133,P2020-0116,P2021-0105"],"award-info":[{"award-number":["P2019-0133,P2020-0116,P2021-0105"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Traumatic brain injury (TBI) or repeated sport-related concussions (rSRC) may lead to long-term memory impairment. Diffusion tensor imaging (DTI) is helpful to reveal global white matter damage but may underestimate focal abnormalities. We investigated the distribution of post-injury regional white matter changes after TBI and rSRC. Six patients with moderate\/severe TBI, and 12 athletes with rSRC were included \u22656 months post-injury, and 10 (age-matched) healthy controls (HC) were analyzed. The Repeatable Battery for the Assessment of Neuropsychological Status was performed at the time of DTI. Major white matter pathways were tracked using q-space diffeomorphic reconstruction and analyzed for global and regional changes with a controlled false discovery rate. TBI patients displayed multiple classic white matter injuries compared with HC (p &lt; 0.01). At the regional white matter analysis, the left frontal aslant tract, anterior thalamic radiation, and the genu of the corpus callosum displayed focal changes in both groups compared with HC but with different trends. Both TBI and rSRC displayed worse memory performance compared with HC (p &lt; 0.05). While global analysis of DTI-based parameters did not reveal common abnormalities in TBI and rSRC, abnormalities to the fronto-thalamic network were observed in both groups using regional analysis of the white matter pathways. These results may be valuable to tailor individualized rehabilitative approaches for post-injury cognitive impairment in both TBI and rSRC patients.<\/jats:p>","DOI":"10.3390\/jcm11020358","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T09:10:36Z","timestamp":1641978636000},"page":"358","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Refined Analysis of Chronic White Matter Changes after Traumatic Brain Injury and Repeated Sports-Related Concussions: Of Use in Targeted Rehabilitative Approaches?"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4702-526X","authenticated-orcid":false,"given":"Francesco","family":"Latini","sequence":"first","affiliation":[{"name":"Section of Neurosurgery, Department of Medical Sciences, Uppsala University, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2502-6026","authenticated-orcid":false,"given":"Markus","family":"Fahlstr\u00f6m","sequence":"additional","affiliation":[{"name":"Section of Radiology, Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Vedung","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, Department of Medical Sciences, Uppsala University, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staffan","family":"Stensson","sequence":"additional","affiliation":[{"name":"Rehabilitation and Pain Centre, Uppsala University Hospital, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elna-Marie","family":"Larsson","sequence":"additional","affiliation":[{"name":"Section of Radiology, Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lubberink","sequence":"additional","affiliation":[{"name":"PET Centre, Uppsala University Hospital, 75185 Uppsala, Sweden"},{"name":"Medical Physics, Uppsala University Hospital, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3628-0705","authenticated-orcid":false,"given":"Yelverton","family":"Tegner","sequence":"additional","affiliation":[{"name":"Division of Health, Medicine and Rehabilitation, Department of Health, Education and Technology, Lule\u00e5 University of Technology, 97187 Lule\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7433-0203","authenticated-orcid":false,"given":"Sven","family":"Haller","sequence":"additional","affiliation":[{"name":"Section of Radiology, Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden"},{"name":"Affidea CDRC Centre de Diagnostic Radiologique de Carouge SA, Clos de la Fonderie, 1227 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Johansson","sequence":"additional","affiliation":[{"name":"Section of Anesthesiology, Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Wall","sequence":"additional","affiliation":[{"name":"PET Centre, Uppsala University Hospital, 75185 Uppsala, Sweden"},{"name":"Section of Nuclear Medicine and PET, Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Antoni","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Uppsala University, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Marklund","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, Department of Medical Sciences, Uppsala University, 75185 Uppsala, Sweden"},{"name":"Section of Neurosurgery, Department of Clinical Sciences Lund, Sk\u00e5ne University Hospital, Lund University, 22184 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,12]]},"reference":[{"key":"ref_1","unstructured":"GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators (2019). 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