{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T13:46:18Z","timestamp":1769694378643,"version":"3.49.0"},"reference-count":36,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>COVID-19 patients often present with rapidly progressing acute hypoxemic respiratory failure, requiring orotracheal intubation with different prognostic issues. However, ICU specialists lack predictive tools to stratify these patients. We conducted a single-center cross-sectional retrospective study to evaluate if the ROX index, measured under non-invasive oxygenation support, can predict ICU mortality in a COVID-19 intubated patient cohort. This study took place in the division of intensive care at the Geneva University Hospitals (Geneva, Switzerland). We included all consecutive adult patients treated by non-invasive oxygenation support and requiring intubation for acute respiratory failure due to COVID-19 between 9 September 2020 and 30 March 2021, corresponding to the second local surge of COVID-19 cases. Baseline demographic data, comorbidities, median ROX between H0 and H8, and clinical outcomes were collected. Overall, 82 patients were intubated after failing a non-invasive oxygenation procedure. Women represented 25.6% of the whole cohort. Median age and median BMI were 70 (60\u201375) years and 28 (25\u201333), respectively. Before intubation, the median ROX between H0 and H8 was 6.3 (5.0\u20138.2). In a multivariate analysis, the median ROX H0\u2013H8 was associated with ICU mortality as a protective factor with an odds ratio (95% CI) = 0.77 (0.60\u20130.99); p &lt; 0.05. In intubated COVID-19 patients treated initially by non-invasive oxygenation support for acute respiratory failure, the median ROX H0\u2013H8 could be an interesting predictive factor associated with ICU mortality.<\/jats:p>","DOI":"10.3390\/jcm11020365","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T09:10:36Z","timestamp":1641978636000},"page":"365","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Early Measurement of ROX Index in Intermediary Care Unit Is Associated with Mortality in Intubated COVID-19 Patients: A Retrospective Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Alexandre","family":"Leszek","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of General Internal Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Wozniak","sequence":"additional","affiliation":[{"name":"Department of Acute Medicine, Intensive Care Unit, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Am\u00e9lie","family":"Giudicelli-Bailly","sequence":"additional","affiliation":[{"name":"Department of Acute Medicine, Intensive Care Unit, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"No\u00e9mie","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Acute Medicine, Intensive Care Unit, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1349-7517","authenticated-orcid":false,"given":"Filippo","family":"Boroli","sequence":"additional","affiliation":[{"name":"Department of Acute Medicine, Intensive Care Unit, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Pugin","sequence":"additional","affiliation":[{"name":"Department of Acute Medicine, Intensive Care Unit, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Grosgurin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of General Internal Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland"},{"name":"Department of Acute Medicine, Intensive Care Unit, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2016-6759","authenticated-orcid":false,"given":"Christophe","family":"Marti","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of General Internal Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland"},{"name":"Department of Acute Medicine, Intensive Care Unit, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5455-5576","authenticated-orcid":false,"given":"Christophe","family":"Le Terrier","sequence":"additional","affiliation":[{"name":"Department of Acute Medicine, Intensive Care Unit, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herv\u00e9","family":"Quintard","sequence":"additional","affiliation":[{"name":"Department of Acute Medicine, Intensive Care Unit, Geneva University Hospitals, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1056\/NEJMcp2009575","article-title":"Severe COVID-19","volume":"383","author":"Berlin","year":"2020","journal-title":"N. 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