{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:27:16Z","timestamp":1791876436822,"version":"4.3.4"},"reference-count":28,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,15]],"date-time":"2022-01-15T00:00:00Z","timestamp":1642204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Bicuspid aortic valve (BAV) is the most common valvular congenital anomaly and is apparent in nearly 50% of candidates for AV replacement. While transcatheter aortic valve implantation (TAVI) is a recommended treatment for patients with symptomatic severe aortic stenosis (AS) at all surgical risk levels, experience with TAVI in severe bicuspid AS is limited. TAVI in BAV is still a challenge due to its association with multiple and complex anatomical considerations. A retrospective study has been conducted to investigate TAVI\u2019s procedural and 30-day outcomes using the Myval transcatheter heart valve (THV) (Meril Life Sciences Pvt. Ltd. Vapi, Gujarat, India) in patients with severe bicuspid AS. Data were collected on 68 patients with severe bicuspid AS who underwent TAVI with the Myval THV. Baseline characteristics, procedural, 30-day echocardiographic and clinical outcomes were collected. The mean age and STS PROM score were 72.6 \u00b1 9.4 and 3.54 \u00b1 2.1. Procedures were performed via the transfemoral route in 98.5%. Major vascular complications (1.5%) and life-threatening bleeding (1.5%) occurred infrequently. No patient had coronary obstruction, second valve implantation or conversion to surgery. On 30-day echocardiography, the mean transvalvular gradient and effective orifice area were 9.8 \u00b1 4.5 mmHg and 1.8 \u00b1 0.4 cm2, respectively. None\/trace aortic regurgitation occurred in 76.5%, mild AR in 20.5% and moderate AR in 3%. The permanent pacemaker implantation rate was 8.5% and 30-day all-cause death occurred in 3.0% of cases. TAVI with the Myval THV in selected BAV anatomy is associated with favorable short-term hemodynamic and clinical outcomes.<\/jats:p>","DOI":"10.3390\/jcm11020443","type":"journal-article","created":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T20:44:00Z","timestamp":1642365840000},"page":"443","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Safety and Efficacy of Myval Implantation in Patients with Severe Bicuspid Aortic Valve Stenosis\u2014A Multicenter Real-World Experience"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6325-1056","authenticated-orcid":false,"given":"Ahmed","family":"Elkoumy","sequence":"first","affiliation":[{"name":"Discipline of Cardiology, Saolta Group, Galway University Hospital, Health Service Executive and CORRIB Core Lab, National University of Ireland Galway (NUIG), H91 V4AY Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Jose","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Christian Medical College & Hospital, Vellore 632004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian J.","family":"Terkelsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, DK-8200 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Nissen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, DK-5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sengottuvelu","family":"Gunasekaran","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Apollo Main Hospital, Greams Road, Chennai 600006, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1040-0019","authenticated-orcid":false,"given":"Mahmoud","family":"Abdelshafy","sequence":"additional","affiliation":[{"name":"Discipline of Cardiology, Saolta Group, Galway University Hospital, Health Service Executive and CORRIB Core Lab, National University of Ireland Galway (NUIG), H91 V4AY Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6883-0287","authenticated-orcid":false,"given":"Ashok","family":"Seth","sequence":"additional","affiliation":[{"name":"Fortis Escorts Heart Institute, New Delhi 110025, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesham","family":"Elzomor","sequence":"additional","affiliation":[{"name":"Discipline of Cardiology, Saolta Group, Galway University Hospital, Health Service Executive and CORRIB Core Lab, National University of Ireland Galway (NUIG), H91 V4AY Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreenivas","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Apollo Hospitals, Apollo Health City, Jubilee Hills, Hyderabad 500050, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4975-6605","authenticated-orcid":false,"given":"Francesco","family":"Bedogni","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IRCCS Policlinico San Donato, 20097 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Ielasi","sequence":"additional","affiliation":[{"name":"Clinical and Interventional Cardiology Unit, Istituto Clinico Sant\u2019Ambrogio, 20149 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh K.","family":"Dora","sequence":"additional","affiliation":[{"name":"Asian Heart Institute, Mumbai 00051, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharad","family":"Chandra","sequence":"additional","affiliation":[{"name":"Department of Cardiology, King George\u2019s Medical University, Lucknow 226003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyur","family":"Parikh","sequence":"additional","affiliation":[{"name":"Care Institute of Medical Sciences, Ahmedabad 380060, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Unic","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Transplant Surgery, University Hospital Dubrava, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Wijns","sequence":"additional","affiliation":[{"name":"Discipline of Cardiology, Saolta Group, Galway University Hospital, Health Service Executive and CORRIB Core Lab, National University of Ireland Galway (NUIG), H91 V4AY Galway, Ireland"},{"name":"C\u00daRAM, The SFI Research Centre for Medical Devices, H91 TK33 Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Baumbach","sequence":"additional","affiliation":[{"name":"William Harvey Research Institute, Queen Mary University of London and Barts Heart Centre, London EC1M 6BQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Mylotte","sequence":"additional","affiliation":[{"name":"Discipline of Cardiology, Saolta Group, Galway University Hospital, Health Service Executive and CORRIB Core Lab, National University of Ireland Galway (NUIG), H91 V4AY Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Serruys","sequence":"additional","affiliation":[{"name":"Discipline of Cardiology, Saolta Group, Galway University Hospital, Health Service Executive and CORRIB Core Lab, National University of Ireland Galway (NUIG), H91 V4AY Galway, Ireland"},{"name":"C\u00daRAM, The SFI Research Centre for Medical Devices, H91 TK33 Galway, Ireland"},{"name":"National Heart and Lung Institute (NHLI), Imperial College London, London SW7 2AZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0758-3539","authenticated-orcid":false,"given":"Osama","family":"Soliman","sequence":"additional","affiliation":[{"name":"Discipline of Cardiology, Saolta Group, Galway University Hospital, Health Service Executive and CORRIB Core Lab, National University of Ireland Galway (NUIG), H91 V4AY Galway, Ireland"},{"name":"C\u00daRAM, The SFI Research Centre for Medical Devices, H91 TK33 Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1136\/heartjnl-2016-309916","article-title":"Contemporary natural history of bicuspid aortic valve disease: A systematic review","volume":"103","author":"Masri","year":"2017","journal-title":"Heart"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1161\/01.CIR.0000155623.48408.C5","article-title":"Frequency by decades of unicuspid, bicuspid, and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis, with or without associated aortic regurgitation","volume":"111","author":"Roberts","year":"2005","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/CIRCULATIONAHA.120.048048","article-title":"Transcatheter Aortic Valve Replacement in Bicuspid Aortic Valve Stenosis","volume":"143","author":"Vincent","year":"2021","journal-title":"Circulation"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Vahanian, A., Beyersdorf, F., Praz, F., Milojevic, M., Baldus, S., Bauersachs, J., Capodanno, D., Conradi, L., De Bonis, M., and De Paulis, R. (2021). 2021 ESC\/EACTS Guidelines for the management of valvular heart disease. Eur. Heart J., ehab395.","DOI":"10.1093\/ejcts\/ezac209"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/j.jacc.2020.11.018","article-title":"2020 ACC\/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"77","author":"Otto","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e203","DOI":"10.1016\/j.athoracsur.2020.08.119","article-title":"International Consensus Statement on Nomenclature and Classification of the Congenital Bicuspid Aortic Valve and Its Aortopathy, for Clinical, Surgical, Interventional and Research Purposes","volume":"112","author":"Michelena","year":"2021","journal-title":"Ann. Thorac. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.jtcvs.2007.01.039","article-title":"A classification system for the bicuspid aortic valve from 304 surgical specimens","volume":"133","author":"Sievers","year":"2007","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1093\/ejcts\/ezab038","article-title":"International consensus statement on nomenclature and classification of the congenital bicuspid aortic valve and its aortopathy, for clinical, surgical, interventional and research purposes","volume":"60","author":"Michelena","year":"2021","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ijcard.2021.06.029","article-title":"Operator preference and determinants of size selection when additional intermediate-size aortic transcatheter heart valves are made available","volume":"338","author":"Kawashima","year":"2021","journal-title":"Int. J. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Garcia-Gomez, M., Delgado-Arana, J.R., Halim, J., De Marco, F., Trani, C., Martin, P., Won-Keun, K., Montorfano, M., den Heijer, P., and Bedogni, F. (2021). Next-generation balloon-expandable Myval transcatheter heart valve in low-risk aortic stenosis patients. Catheter. Cardiovasc. Interv.","DOI":"10.1002\/ccd.29923"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Delgado-Arana, J.R., Gordillo-Monge, M.X., Halim, J., De Marco, F., Trani, C., Martin, P., Infusino, F., Ancona, M., den Heijer, P., and Bedogni, F. (2021). Early clinical and haemodynamic matched comparison of balloon-expandable valves. Heart.","DOI":"10.1136\/heartjnl-2021-319349"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"421","DOI":"10.4244\/EIJ-D-19-00413","article-title":"First-in-human evaluation of a novel balloon-expandable transcatheter heart valve in patients with severe symptomatic native aortic stenosis: The MyVal-1 study","volume":"16","author":"Sharma","year":"2020","journal-title":"EuroIntervention"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1093\/eurheartj\/ehu281","article-title":"2014 ESC Guidelines on the diagnosis and treatment of aortic diseases: Document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC)","volume":"35","author":"Erbel","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Varc-3 Writing, C., Genereux, P., Piazza, N., Alu, M.C., Nazif, T., Hahn, R.T., Pibarot, P., Bax, J.J., Leipsic, J.A., and Blanke, P. (2021). Valve Academic Research Consortium 3: Updated endpoint definitions for aortic valve clinical research. Eur. Heart J., 42, 1825\u20131857.","DOI":"10.1093\/eurheartj\/ehaa799"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1093\/ejcts\/ezs533","article-title":"Updated standardized endpoint definitions for transcatheter aortic valve implantation: The Valve Academic Research Consortium-2 consensus document (VARC-2)","volume":"42","author":"Kappetein","year":"2012","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/ehjci\/jew025","article-title":"Recommendations for the imaging assessment of prosthetic heart valves: A report from the European Association of Cardiovascular Imaging endorsed by the Chinese Society of Echocardiography, the Inter-American Society of Echocardiography, and the Brazilian Department of Cardiovascular Imaging","volume":"17","author":"Lancellotti","year":"2016","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1093\/eurheartj\/ehr259","article-title":"EAE\/ASE recommendations for the use of echocardiography in new transcatheter interventions for valvular heart disease","volume":"32","author":"Zamorano","year":"2011","journal-title":"Eur. Heart J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.echo.2019.01.003","article-title":"Guidelines for the Evaluation of Valvular Regurgitation After Percutaneous Valve Repair or Replacement: A Report from the American Society of Echocardiography Developed in Collaboration with the Society for Cardiovascular Angiography and Interventions, Japanese Society of Echocardiography, and Society for Cardiovascular Magnetic Resonance","volume":"32","author":"Zoghbi","year":"2019","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"20","DOI":"10.5334\/gh.959","article-title":"Quantitative Angiographic Assessment of Aortic Regurgitation after Transcatheter Aortic Valve Implantation among Three Balloon-Expandable Valves","volume":"16","author":"Kawashima","year":"2021","journal-title":"Glob. Heart"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1001\/jama.2021.13229","article-title":"Transcatheter Valve Replacement for Bicuspid Aortic Stenosis","volume":"326","author":"Otto","year":"2021","journal-title":"JAMA"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/icvts\/ivaa231","article-title":"Outcome of transcatheter aortic valve replacement in bicuspid aortic valve stenosis with new-generation devices","volume":"32","author":"Gorla","year":"2021","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ijcard.2020.05.076","article-title":"Supra-annular sizing of transcatheter aortic valve prostheses in raphe-type bicuspid aortic valve disease: The LIRA method","volume":"317","author":"Iannopollo","year":"2020","journal-title":"Int. J. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.jacc.2020.07.005","article-title":"Bicuspid Aortic Valve Morphology and Outcomes After Transcatheter Aortic Valve Replacement","volume":"76","author":"Yoon","year":"2020","journal-title":"J. Am. Coll Cardiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1001\/jama.2021.13346","article-title":"Association Between Transcatheter Aortic Valve Replacement for Bicuspid vs Tricuspid Aortic Stenosis and Mortality or Stroke Among Patients at Low Surgical Risk","volume":"326","author":"Makkar","year":"2021","journal-title":"JAMA"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ijcard.2020.10.050","article-title":"Procedural and clinical outcomes of type 0 versus type 1 bicuspid aortic valve stenosis undergoing trans-catheter valve replacement with new generation devices: Insight from the BEAT international collaborative registry","volume":"325","author":"Ielasi","year":"2021","journal-title":"Int. J. Cardiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jcct.2020.01.008","article-title":"Annular versus supra-annular sizing for transcatheter aortic valve replacement in bicuspid aortic valve disease","volume":"14","author":"Blanke","year":"2020","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jcct.2020.01.007","article-title":"Bicuspid aortic valve sizing for transcatheter aortic valve implantation: Development and validation of an algorithm based on multi-slice computed tomography","volume":"14","author":"Petronio","year":"2020","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e231","DOI":"10.4244\/EIJ-D-19-00236","article-title":"Annular versus supra-annular sizing for TAVI in bicuspid aortic valve stenosis","volume":"15","author":"Kim","year":"2019","journal-title":"EuroIntervention"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/2\/443\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:27:31Z","timestamp":1760362051000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/2\/443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,15]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["jcm11020443"],"URL":"https:\/\/doi.org\/10.3390\/jcm11020443","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,15]]}}}