{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:56:27Z","timestamp":1790686587729,"version":"4.1.0"},"reference-count":45,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Endometriosis is a disease that is becoming more and more challenging for the medical community. The current therapeutic concepts (surgical therapy and\/or hormonal therapies) often do not lead to sufficient pain control, and late diagnosis and high recurrence rates mean that women affected by the disease can suffer for decades before receiving proper treatment. Although the introduction of certified endometriosis centers has created contact points for surgical therapies performed by endometriosis experts, these centers are not sufficient to offer the affected patients the all-encompassing long-term support they need. In recent years, new findings regarding the pathogenesis and correlations of the pain phenomena caused by endometriosis have shown that conventional therapy strategies are not adequate and individual long-term concepts must be developed. Not only can endometriosis cause nociceptive pain, but it can also lead to a nociplastic reaction with central sensitization. Hence, aside from the classic cyclic complaints, patients increasingly suffer from atypical pain. Due to the high number of affected patients who are treated inadequately, it is necessary for gynecologists in private practices to become familiar with multimodal treatment concepts since they are the central point of contact of their patients. The following article will provide an overview of treatment strategies for chronic symptomatic endometriosis.<\/jats:p>","DOI":"10.3390\/jcm11020467","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T20:46:03Z","timestamp":1642452363000},"page":"467","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Endometriosis, an Ongoing Pain\u2014Step-by-Step Treatment"],"prefix":"10.3390","volume":"11","author":[{"given":"Sylvia","family":"Mechsner","sequence":"first","affiliation":[{"name":"Clinic for Gynecology, Endometriosis Center Charit\u00e9, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.bpobgyn.2004.01.003","article-title":"Impact of endometriosis on women\u2019s health: Comparative historical data show that the earlier the onset, the more severe the disease","volume":"18","author":"Ballweg","year":"2004","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1097\/AOG.0b013e3181758ec6","article-title":"Surgical treatment of endometriosis: A 7-year follow-up on the requirement for further surgery","volume":"111","author":"Shakiba","year":"2008","journal-title":"Obstet. Gynecol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejogrb.2017.03.011","article-title":"Effects of long-term postoperative dienogest use for treatment of endometriosis on bone mineral density","volume":"212","author":"Seo","year":"2017","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1055\/s-0034-1366278","article-title":"Definition, classification and diagnosis of diabetes mellitus","volume":"122","author":"Kerner","year":"2014","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.fertnstert.2007.11.020","article-title":"Diagnostic experience among 4334 women reporting surgically diagnosed endometriosis","volume":"91","author":"Greene","year":"2009","journal-title":"Fertil. Steril."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jogc.2019.08.034","article-title":"Endometriosis and Negative Perception of the Medical Profession","volume":"42","author":"Ng","year":"2020","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"ref_7","unstructured":"Klatt, F. (2021, January 14). Ist die Betreuung von Endometriosepatientinnen in der Praxis gesundheits\u00f6konomisch sinnvoll?. Available online: http:\/\/dx.doi.org\/10.17169\/refubium-28196."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.fertnstert.2017.05.004","article-title":"Reevaluating response and failure of medical treatment of endometriosis: A systematic review","volume":"108","author":"Becker","year":"2017","journal-title":"Fertil. Steril."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/humrep\/den379","article-title":"Surgery for endometriosis-associated infertility: A pragmatic approach","volume":"24","author":"Vercellini","year":"2009","journal-title":"Hum. Reprod."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00482-016-0154-1","article-title":"Endometriosis: An often unrecognized pain disorder","volume":"30","author":"Mechsner","year":"2016","journal-title":"Schmerz"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Gruber, T.M., and Mechsner, S. (2021). Pathogenesis of Endometriosis: The Origin of Pain and Subfertility. Cells, 10.","DOI":"10.3390\/cells10061381"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41574-019-0245-z","article-title":"Rethinking mechanisms, diagnosis and management of endometriosis","volume":"15","author":"Chapron","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.fertnstert.2017.01.003","article-title":"Progestin-only pills may be a better first-line treatment for endometriosis than combined estrogen-progestin contraceptive pills","volume":"107","author":"Casper","year":"2017","journal-title":"Fertil. Steril."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/humrep\/det457","article-title":"ESHRE guideline: Management of women with endometriosis","volume":"29","author":"Dunselman","year":"2014","journal-title":"Hum. Reprod."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"200","DOI":"10.5301\/jeppd.5000286","article-title":"Endometriosis-associated Pain in Patients with and without Hormone Therapy","volume":"9","author":"Brandes","year":"2017","journal-title":"J. Endometr. Pelvic Pain Disord."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00482-021-00543-8","article-title":"Endometrioseschmerz Beherrschen","volume":"35","author":"Mechsner","year":"2021","journal-title":"Der Schmerz"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/humrep\/dep469","article-title":"Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: A 24-week, randomized, multicentre, open-label trial","volume":"25","author":"Strowitzki","year":"2010","journal-title":"Hum. Reprod."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1080\/14656566.2018.1494154","article-title":"Current and emerging treatment options for endometriosis","volume":"19","author":"Ferrero","year":"2018","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/s00404-020-05686-0","article-title":"Post-operative management and follow-up of surgical treatment in the case of rectovaginal and retrocervical endometriosis","volume":"302","author":"Abesadze","year":"2020","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1177\/1933719110381927","article-title":"Generalized hyperalgesia in women with endometriosis and its resolution following a successful surgery","volume":"17","author":"He","year":"2010","journal-title":"Reprod. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ijgo.2009.08.020","article-title":"A dose-ranging study to determine the efficacy and safety of 1, 2, and 4mg of dienogest daily for endometriosis","volume":"108","author":"Faustmann","year":"2010","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/0002-9378(77)90111-9","article-title":"The treatment of dysmenorrhea with naproxen sodium: A report on two independent double-blind trials","volume":"127","author":"Henzl","year":"1977","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2174\/1573397111666150619094524","article-title":"Central and peripheral pain generators in women with chronic pelvic pain: Patient centered assessment and treatment","volume":"11","author":"Hoffman","year":"2015","journal-title":"Curr. Rheumatol. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1089\/can.2016.0035","article-title":"The Clinical Significance of Endocannabinoids in Endometriosis Pain Management","volume":"2","author":"Bouaziz","year":"2017","journal-title":"Cannabis. Cannabinoid. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.brainresrev.2008.12.017","article-title":"Peripheral mechanisms of pain and analgesia","volume":"60","author":"Stein","year":"2009","journal-title":"Brain Res. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jri.2013.03.003","article-title":"Chemokines in the pathogenesis of endometriosis and infertility","volume":"98","author":"Borrelli","year":"2013","journal-title":"J. Reprod. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1055\/s-2004-830535","article-title":"Chronischer Unterbauchschmerz Am. Beispiel der Endometriose-Problempatientin in der Gyn\u00e4kologie?","volume":"65","author":"Finas","year":"2005","journal-title":"Geburtshilfe Frauenheilkd."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1089\/acm.2015.0343","article-title":"The Practice of Hatha Yoga for the Treatment of Pain Associated with Endometriosis","volume":"23","author":"Barros","year":"2017","journal-title":"J. Altern. Complement. Med."},{"key":"ref_29","first-page":"286","article-title":"Alternative treatment possibilities of complaints due to endometriosis","volume":"125","author":"Wienhard","year":"2003","journal-title":"Zentralbl. Gynakol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.rbmo.2021.07.011","article-title":"Diet quality and perceived effects of dietary changes in Dutch endometriosis patients: An observational study","volume":"43","author":"Krabbenborg","year":"2021","journal-title":"Reprod. Biomed. Online"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1038\/s41598-019-39700-6","article-title":"The Endobiota Study: Comparison of Vaginal, Cervical and Gut Microbiota Between Women with Stage 3\/4 Endometriosis and Healthy Controls","volume":"9","author":"Ata","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/ajcn\/nqaa096","article-title":"Supplementation with vitamin D or \u03c9-3 fatty acids in adolescent girls and young women with endometriosis (SAGE): A double-blind, randomized, placebo-controlled trial","volume":"112","author":"Nodler","year":"2020","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1001\/archinternmed.2011.715","article-title":"Improvement of primary dysmenorrhea caused by a single oral dose of vitamin D: Results of a randomized, double-blind, placebo-controlled study","volume":"172","author":"Lasco","year":"2012","journal-title":"Arch. Intern. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1093\/humrep\/des150","article-title":"The selective vitamin D receptor agonist, elocalcitol, reduces endometriosis development in a mouse model by inhibiting peritoneal inflammation","volume":"27","author":"Mariani","year":"2012","journal-title":"Hum. Reprod."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1210\/jc.2016-1515","article-title":"Effects of 1,25-Dihydroxy Vitamin D3 on Endometriosis","volume":"101","author":"Miyashita","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_36","first-page":"595","article-title":"The peritoneum\u2014An important factor for pathogenesis and pain generation in endometriosis","volume":"92","author":"Mechsner","year":"2014","journal-title":"J. Mol. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.rbmo.2011.10.003","article-title":"Adenomyosis and infertility","volume":"24","author":"Campo","year":"2012","journal-title":"Reprod. Biomed. Online"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.fertnstert.2008.06.003","article-title":"Associated ovarian endometrioma is a marker for greater severity of deeply infiltrating endometriosis","volume":"92","author":"Chapron","year":"2009","journal-title":"Fertil. Steril."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bpobgyn.2018.01.011","article-title":"Endometrial stem\/progenitor cells and their role in the pathogenesis of endometriosis","volume":"50","author":"Cousins","year":"2018","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1093\/humrep\/det284","article-title":"The significant effect of endometriosis on physical, mental and social wellbeing: Results from an international cross-sectional survey","volume":"28","author":"Dunselman","year":"2013","journal-title":"Hum. Reprod."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S0140-6736(10)60490-4","article-title":"Endometriosis and infertility: Pathophysiology and management","volume":"376","author":"Borghese","year":"2010","journal-title":"Lancet"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1056\/NEJMct0806114","article-title":"Acupuncture for chronic low back pain","volume":"363","author":"Berman","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2147\/JPR.S55580","article-title":"Is acupuncture effective in the treatment of pain in endometriosis?","volume":"9","author":"Lund","year":"2016","journal-title":"J. Pain Res."},{"key":"ref_44","first-page":"716","article-title":"Botulinum Toxin to Treat Endometriosis Pain","volume":"322","author":"Rubin","year":"2019","journal-title":"JAMA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1055\/s-0042-106799","article-title":"Neuraltherapie in der Frauenheilkunde\u2014Update 2016","volume":"76","author":"Weinschenk","year":"2016","journal-title":"Geburtshilfe Frauenheilkd."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/2\/467\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:02:49Z","timestamp":1760133769000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/2\/467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,17]]},"references-count":45,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["jcm11020467"],"URL":"https:\/\/doi.org\/10.3390\/jcm11020467","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,17]]}}}