{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:47:05Z","timestamp":1760150825930,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kinderherzen F\u00f6rdergemeinschaft Deutsche Kinderherzzentren e.V","award":["W-M-025\/2017"],"award-info":[{"award-number":["W-M-025\/2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The life expectancy of patients with Tetralogy of Fallot (ToF) has increased in recent years. As a result, other risk factors with later onset in life are in the focus of patient care. Endothelial function is an early indicator of cardiovascular risk and was investigated along further structural vessel properties. A total of 17 patients (41.7 \u00b1 7.1 years, 8 women) with Tetralogy of Fallot were 1:2 matched for sex with 34 (38.9 \u00b1 8.1 years, 16 women) healthy volunteers. Participants received an assessment of their endothelial function and a structural assessment of the aorta. Patients with ToF showed a reduced endothelial function determined by reactive hyperaemia index after adjusting for age, weight and height (ToF: 1.55 \u00b1 0.31 vs. controls: 1.84 \u00b1 0.47; p = 0.023). No differences in carotid intima-media thickness (cIMT) between the ToF and healthy controls (ToF: 0.542 \u00b1 0.063 mm vs. controls: 0.521 \u00b1 0.164 mm; p = 0.319) were found. Patients with ToF had reduced vascular function compared to healthy subjects. As the structural component is not affected, endothelial dysfunction seems not to have yet manifested itself as a morphological change. Nevertheless, long-term management of these patients should include vascular parameters.<\/jats:p>","DOI":"10.3390\/jcm11030493","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T08:20:57Z","timestamp":1642580457000},"page":"493","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Diminished Endothelial Function but Normal Vascular Structure in Adults with Tetralogy of Fallot"],"prefix":"10.3390","volume":"11","author":[{"given":"Daniel","family":"Goeder","sequence":"first","affiliation":[{"name":"German Heart Centre Munich, Department of Paediatric Cardiology and Congenital Heart Disease, Technical University Munich, 80636 Munich, Germany"},{"name":"Institute of Preventive Pediatrics, Technical University Munich, 80992 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3166-0488","authenticated-orcid":false,"given":"Renate","family":"Oberhoffer-Fritz","sequence":"additional","affiliation":[{"name":"German Heart Centre Munich, Department of Paediatric Cardiology and Congenital Heart Disease, Technical University Munich, 80636 Munich, Germany"},{"name":"Institute of Preventive Pediatrics, Technical University Munich, 80992 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Brudy","sequence":"additional","affiliation":[{"name":"German Heart Centre Munich, Department of Paediatric Cardiology and Congenital Heart Disease, Technical University Munich, 80636 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8577-4480","authenticated-orcid":false,"given":"Laura","family":"Willinger","sequence":"additional","affiliation":[{"name":"German Heart Centre Munich, Department of Paediatric Cardiology and Congenital Heart Disease, Technical University Munich, 80636 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3970-514X","authenticated-orcid":false,"given":"Michael","family":"Meyer","sequence":"additional","affiliation":[{"name":"German Heart Centre Munich, Department of Paediatric Cardiology and Congenital Heart Disease, Technical University Munich, 80636 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0253-1190","authenticated-orcid":false,"given":"Peter","family":"Ewert","sequence":"additional","affiliation":[{"name":"German Heart Centre Munich, Department of Paediatric Cardiology and Congenital Heart Disease, Technical University Munich, 80636 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7530-2025","authenticated-orcid":false,"given":"Jan","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"German Heart Centre Munich, Department of Paediatric Cardiology and Congenital Heart Disease, Technical University Munich, 80636 Munich, Germany"},{"name":"Institute of Preventive Pediatrics, Technical University Munich, 80992 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1136\/heartjnl-2014-305575","article-title":"Acquired heart conditions in adults with congenital heart disease: A growing problem","volume":"100","author":"Tutarel","year":"2014","journal-title":"Heart"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1093\/eurheartj\/eht572","article-title":"Recommendations for organization of care for adults with congenital heart disease and for training in the subspecialty of \u2018Grown-up Congenital Heart Disease\u2019 in Europe: A position paper of the Working Group on Grown-up Congenital Heart Disease of the European Society of Cardiology","volume":"35","author":"Baumgartner","year":"2014","journal-title":"Eur. 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