{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:32:12Z","timestamp":1791048732540,"version":"4.1.0"},"reference-count":29,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K09661"],"award-info":[{"award-number":["18K09661"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Metal allergy is a T-cell-mediated delayed type of hypersensitive reaction. The pathogenetic mechanisms underlying the allergy are unclear, although the condition has been reported to be related to oral lichen planus (OLP), despite an absence of immunological studies to support this relationship. In this study, histopathological samples of OLP patients were examined to compare the metal allergy-positive and -negative groups, with a focus on the network of epidermal keratinocytes and T cells induced by thymic stromal lymphopoietin (TSLP) and its receptor, TSLPR. Infiltration of T cells into the epithelium was revealed to be higher in the OLP lesions of metal allergy-positive patients than in those of metal allergy-negative patients. Moreover, TSLP-TSLPR signaling and TNF-\u03b1 production were higher in the epithelial tissue samples of the metal allergy-positive patients than in the metal allergy-negative patients. Metal allergy is associated with both increased expressions of TSLP in keratinocytes and increased TNF-\u03b1 levels in the epithelium. We propose that this would promote the accumulation of T cells at the lesion site, contributing to the formation of the disease. These results suggest that metal allergy may be an aggravating factor in the pathogenesis of OLP.<\/jats:p>","DOI":"10.3390\/jcm11030519","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T22:51:06Z","timestamp":1642719066000},"page":"519","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Metal Allergy Mediates the Development of Oral Lichen Planus via TSLP-TSLPR Signaling"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8447-5219","authenticated-orcid":false,"given":"Mohammad Fadyl","family":"Yunizar","sequence":"first","affiliation":[{"name":"Department of Prosthodontics & Oral Rehabilitation, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto, Tokushima 770-8504, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics & Oral Rehabilitation, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto, Tokushima 770-8504, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8248-3063","authenticated-orcid":false,"given":"Lipei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics & Oral Rehabilitation, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto, Tokushima 770-8504, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norikazu","family":"Minami","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics & Oral Rehabilitation, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto, Tokushima 770-8504, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0950-9957","authenticated-orcid":false,"given":"Tetsuo","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics & Oral Rehabilitation, Graduate School of Biomedical Sciences, Tokushima University, 3-18-15, Kuramoto, Tokushima 770-8504, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1034\/j.1398-9995.2000.00107.x","article-title":"Immunologic mechanisms in hypersensitivity reactions to metal ions: An overview","volume":"55","author":"Hertl","year":"2000","journal-title":"Allergy"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/ACI.0b013e3283088cf9","article-title":"From innate to adaptive immune responses in contact hypersensitivity","volume":"8","author":"Martin","year":"2008","journal-title":"Curr. 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