{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:55:53Z","timestamp":1777643753486,"version":"3.51.4"},"reference-count":37,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Innovative Medizinische Forschung, Medical Faculty, University of M\u00fcnster","award":["JE 212005"],"award-info":[{"award-number":["JE 212005"]}]},{"name":"Open Access Publication Fund of University of M\u00fcnster.","award":["XXX"],"award-info":[{"award-number":["XXX"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Kidney transplant (KTx) recipients are a high-risk population for osteoporotic fractures. We herein aim to identify the role of pre-transplant parathyroidectomy (PTX) and other modifiable factors associated with osteoporotic fractures in KTx recipients. We conducted a retrospective study involving 711 adult patients (4608 patient-years) who were transplanted at our center between January 2007 and June 2015. Clinical data were extracted from patients\u2019 electronic medical records. Different laboratory and clinical parameters for mineral bone disease (MBD) and osteoporosis, including medication, were evaluated. We chose fracture events unrelated to malignancies or adequate trauma as the primary endpoint. Osteoporotic fractures occurred in 47 (6.6%) patients (median 36.7 months, IQR 45.9) after KTx (fracture incidence of 10 per 1000 person-years). Prior to KTx, subtotal PTX was performed in 116 patients (16.3%, median time 4.2 years before KTx, IQR 5.0). Of the patients with fracture (n = 47), only one (2.2%) patient had previously undergone PTX. After adjusting for the known fracture risk factors MBD and osteoporosis, PTX remained a protective factor against fractures (HR 0.134, CI 0.018\u20130.991, p = 0.049). We observed a reduced risk for pathological fractures in KTx patients who underwent PTX, independent from elevated parathyroid hormone at the time of KTx or afterwards.<\/jats:p>","DOI":"10.3390\/jcm11030654","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T22:00:56Z","timestamp":1643320856000},"page":"654","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Influence of Parathyroidectomy on Osteoporotic Fractures in Kidney Transplant Recipients: Results from a Retrospective Single-Center Trial"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1136-438X","authenticated-orcid":false,"given":"Ulrich","family":"Jehn","sequence":"first","affiliation":[{"name":"Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Muenster, 48149 Muenster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Kortenhorn","sequence":"additional","affiliation":[{"name":"Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Muenster, 48149 Muenster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Sch\u00fctte-N\u00fctgen","sequence":"additional","affiliation":[{"name":"Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Muenster, 48149 Muenster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3180-6245","authenticated-orcid":false,"given":"Gerold","family":"Th\u00f6lking","sequence":"additional","affiliation":[{"name":"Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Muenster, 48149 Muenster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Westphal","sequence":"additional","affiliation":[{"name":"Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Muenster, 48149 Muenster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Strauss","sequence":"additional","affiliation":[{"name":"Department of Medicine C, Division of Cardiology and Angiology, University Hospital of Muenster, 48149 Muenster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk-Oliver","family":"Wennmann","sequence":"additional","affiliation":[{"name":"Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Muenster, 48149 Muenster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann","family":"Pavenst\u00e4dt","sequence":"additional","affiliation":[{"name":"Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Muenster, 48149 Muenster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Suwelack","sequence":"additional","affiliation":[{"name":"Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Muenster, 48149 Muenster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2574-9419","authenticated-orcid":false,"given":"Dennis","family":"G\u00f6rlich","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Clinical Research, University of Muenster, 48149 Muenster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6345-6206","authenticated-orcid":false,"given":"Stefan","family":"Reuter","sequence":"additional","affiliation":[{"name":"Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Muenster, 48149 Muenster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0140-6736(98)09075-8","article-title":"Mortality after all major types of osteoporotic fracture in men and women: An observational study","volume":"353","author":"Center","year":"1999","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/nep.13457","article-title":"Mineral bone disorders in chronic kidney disease","volume":"23","author":"Hou","year":"2018","journal-title":"Nephrology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.transproceed.2007.11.040","article-title":"Impact of calcineurin inhibitors on bone metabolism in primary kidney transplant patients","volume":"40","author":"Bozkaya","year":"2008","journal-title":"Transplant. Proc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.2169\/internalmedicine.8618-16","article-title":"Management of Osteoporosis in Chronic Kidney Disease","volume":"56","author":"Nitta","year":"2017","journal-title":"Intern. Med."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Matei, A., Bilha, S.C., Constantinescu, D., Pavel-Tanasa, M., Cianga, P., Covic, A., and Branisteanu, D.D. (2021). Body composition, adipokines, FGF23-Klotho and bone in kidney transplantation: Is there a link?. J. Nephrol., Ahead of print.","DOI":"10.1007\/s40620-021-00972-9"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"(2017). KDIGO 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney Int. Suppl., 7, 1\u201359.","DOI":"10.1016\/j.kisu.2017.04.001"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1111\/j.1744-9987.2008.00627.x","article-title":"Parathyroidectomy for secondary hyperparathyroidism in the era of calcimimetics","volume":"12","author":"Tominaga","year":"2008","journal-title":"Ther. Apher. Dial."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"715","DOI":"10.7326\/M15-1232","article-title":"The Relationship of Parathyroidectomy and Bisphosphonates with Fracture Risk in Primary Hyperparathyroidism: An Observational Study","volume":"164","author":"Yeh","year":"2016","journal-title":"Ann. Intern. Med."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Sch\u00fctte-N\u00fctgen, K., Th\u00f6lking, G., Steinke, J., Pavenst\u00e4dt, H., Schmidt, R., Suwelack, B., and Reuter, S. (2019). Fast Tac Metabolizers at Risk\u2014It is Time for a C\/D Ratio Calculation. J. Clin. Med., 8.","DOI":"10.3390\/jcm8050587"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1111\/ajt.12425","article-title":"Persistent hyperparathyroidism is a major risk factor for fractures in the five years after kidney transplantation","volume":"13","author":"Perrin","year":"2013","journal-title":"Am. J. Transplant."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1001\/jama.2009.50","article-title":"Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women","volume":"301","author":"Bliuc","year":"2009","journal-title":"JAMA"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.kint.2018.12.024","article-title":"Bone mineral density, bone turnover markers, and incident fractures in de novo kidney transplant recipients","volume":"95","author":"Evenepoel","year":"2019","journal-title":"Kidney Int."},{"key":"ref_13","first-page":"CD005015","article-title":"Interventions for preventing bone disease in kidney transplant recipients","volume":"10","author":"Palmer","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1681\/ASN.2007010022","article-title":"Fracture risk after parathyroidectomy among chronic hemodialysis patients","volume":"18","author":"Rudser","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1097\/00007890-199410270-00009","article-title":"Bone fracture and osteodensitometry with dual energy X-ray absorptiometry in kidney transplant recipients","volume":"58","author":"Grotz","year":"1994","journal-title":"Transplantation"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/00007890-200208150-00012","article-title":"Risk factors for fractures in kidney transplantation","volume":"74","author":"Dahl","year":"2002","journal-title":"Tranplantation"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.kint.2021.04.043","article-title":"Differentiating the causes of adynamic bone in advanced chronic kidney disease informs osteoporosis treatment","volume":"100","author":"Haarhaus","year":"2021","journal-title":"Kidney Int."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1159\/000504139","article-title":"Cinacalcet Treatment Significantly Improves All-Cause and Cardiovascular Survival in Dialysis Patients: Results from a Meta-Analysis","volume":"44","author":"Zu","year":"2019","journal-title":"Kidney Blood Press. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e13988","DOI":"10.1111\/ctr.13988","article-title":"Long-term results of a randomized study comparing parathyroidectomy with cinacalcet for treating tertiary hyperparathyroidism","volume":"34","author":"Moreno","year":"2020","journal-title":"Clin. Transplant."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1007\/s00268-017-4000-0","article-title":"The Effect of Parathyroidectomy on Risk of Hip Fracture in Secondary Hyperparathyroidism","volume":"41","author":"Isaksson","year":"2017","journal-title":"World J. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1681\/ASN.2015060622","article-title":"A Randomized Study Comparing Parathyroidectomy with Cinacalcet for Treating Hypercalcemia in Kidney Allograft Recipients with Hyperparathyroidism","volume":"27","author":"Cruzado","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1093\/ndt\/gfh892","article-title":"Impact of parathyroidectomy on renal graft function, blood pressure and serum lipids in kidney transplant recipients: A single centre study","volume":"20","author":"Evenepoel","year":"2005","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"952","DOI":"10.2215\/CJN.10390917","article-title":"Parathyroidectomy in the Management of Secondary Hyperparathyroidism","volume":"13","author":"Lau","year":"2018","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e366","DOI":"10.1097\/TP.0000000000003653","article-title":"Association Between Treatment of Secondary Hyperparathyroidism and Posttransplant Outcomes","volume":"105","author":"Mathur","year":"2021","journal-title":"Transplantation"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s00423-020-01953-5","article-title":"Outcomes of parathyroidectomy versus calcimimetics for secondary hyperparathyroidism and kidney transplantation: A propensity-matched analysis","volume":"405","author":"Koh","year":"2020","journal-title":"Langenbecks Arch. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00423-019-01755-4","article-title":"Parathyroidectomy versus cinacalcet for tertiary hyperparathyroidism; a retrospective analysis","volume":"404","author":"Dulfer","year":"2019","journal-title":"Langenbecks Arch. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.surg.2018.04.090","article-title":"Parathyroidectomy versus Cinacalcet in the Management of Tertiary Hyperparathyroidism: Surgery Improves Renal Transplant Allograft Survival","volume":"165","author":"Finnerty","year":"2019","journal-title":"Surgery"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s40265-019-01074-4","article-title":"Management of Post-transplant Hyperparathyroidism and Bone Disease","volume":"79","author":"Rossi","year":"2019","journal-title":"Drugs"},{"key":"ref_29","unstructured":"(2009). KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney Int. Suppl., 76, S1\u2013S2."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1053\/j.ajkd.2014.05.018","article-title":"25-Hydroxyvitamin D testing and supplementation in CKD: An NKF-KDOQI controversies report","volume":"64","author":"Kramer","year":"2014","journal-title":"Am. J. Kidney Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1056\/NEJMcp1800214","article-title":"Glucocorticoid-Induced Osteoporosis","volume":"379","author":"Buckley","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.intimp.2012.03.019","article-title":"Impact of tacrolimus on bone metabolism after kidney transplantation","volume":"13","author":"Luo","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2220\/biomedres.39.131","article-title":"Effects of the calcineurin inhibitors cyclosporine and tacrolimus on bone metabolism in rats","volume":"39","author":"Kanda","year":"2018","journal-title":"Biomed. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"342","DOI":"10.2174\/1389200219666180101104159","article-title":"Tacrolimus\u2014Pharmacokinetic Considerations for Clinicians","volume":"19","author":"Tholking","year":"2018","journal-title":"Curr. Drug Metab."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1093\/ndt\/gfy306","article-title":"Natural history of mineral metabolism, bone turnover and bone mineral density in de novo renal transplant recipients treated with a steroid minimization immunosuppressive protocol","volume":"35","author":"Evenepoel","year":"2020","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.kint.2020.07.041","article-title":"Mineral bone disease in autosomal dominant polycystic kidney disease","volume":"99","author":"Gitomer","year":"2021","journal-title":"Kidney Int."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"115554","DOI":"10.1016\/j.bone.2020.115554","article-title":"Fractures after kidney transplantation: Incidence, predictors, and association with mortality","volume":"140","author":"Iseri","year":"2020","journal-title":"Bone"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/3\/654\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:09:01Z","timestamp":1760134141000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/3\/654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,27]]},"references-count":37,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["jcm11030654"],"URL":"https:\/\/doi.org\/10.3390\/jcm11030654","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,27]]}}}