{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:36:56Z","timestamp":1785908216372,"version":"3.56.0"},"reference-count":37,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Foundation for the Astrid Lindgren Children\u2019s Hospital Stockholm","award":["2018"],"award-info":[{"award-number":["2018"]}]},{"name":"The S\u00e4llskapet Barnav\u00e5rd Foundation","award":["2011, 2013, 2014, 2015"],"award-info":[{"award-number":["2011, 2013, 2014, 2015"]}]},{"name":"the Samariten Foundation","award":["2012, 2013"],"award-info":[{"award-number":["2012, 2013"]}]},{"name":"H.R.H Princess Lovisa Foundation","award":["2010"],"award-info":[{"award-number":["2010"]}]},{"name":"the Swedish Heart-Lung Foundation Grant 2013-0469","award":["2013-0469"],"award-info":[{"award-number":["2013-0469"]}]},{"name":"Stockholm County Council and Karolinska Institutet, and the Neonatal Department, Karolinska University Hospital","award":["2010-2016"],"award-info":[{"award-number":["2010-2016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The aim was to investigate the association of gestational age (GA), echocardiographic markers and levels of plasma N-terminal pro-B-type natriuretic peptide (NTproBNP) with the closure rate of a haemodynamically significant patent ductus arteriosus (hsPDA). Ninety-eight Swedish extremely preterm infants, mean GA 25.7 weeks (standard deviation 1.3), born in 2012\u20132014, were assessed with echocardiography and for levels of NTproBNP. Thirty-three (34%) infants had spontaneous ductal closure within three weeks of age. Infants having spontaneous closure at seven days or less had significantly lower NTproBNP levels on day three, median 1810 ng\/L (IQR 1760\u20136000 ng\/L) compared with: infants closing spontaneously later, 10,900 ng\/L (6120\u201319,200 ng\/L); infants treated either with ibuprofen only, 14,600 ng\/L (7740\u201328,100 ng\/L); or surgery, 32,300 ng\/L (29,100\u201335,000 ng\/L). Infants receiving PDA surgery later had significantly higher NTproBNP values on day three than other infants. Day three NTproBNP cut-off values of 15,001\u201318,000 ng\/L, predicted later PDA surgery, with an area under the curve in ROC analysis of 0.69 (0.54\u20130.83). In conclusion, the spontaneous PDA closure rate is relatively high in extremely preterm infants. Early NTproBNP levels can be used with GA in the management decisions of hsPDA.<\/jats:p>","DOI":"10.3390\/jcm11030667","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T22:00:56Z","timestamp":1643320856000},"page":"667","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Early N-Terminal Pro B-Type Natriuretic Peptide (NTproBNP) Plasma Values and Associations with Patent Ductus Arteriosus Closure and Treatment\u2014An Echocardiography Study of Extremely Preterm Infants"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0428-6707","authenticated-orcid":false,"given":"Anna","family":"Gudmundsdottir","sequence":"first","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet, 171 77 Stockholm, Sweden"},{"name":"Department of Neonatology, Astrid Lindgren Children\u2019s Hospital, Karolinska University Hospital, 171 64 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bartocci","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet, 171 77 Stockholm, Sweden"},{"name":"Department of Neonatology, Astrid Lindgren Children\u2019s Hospital, Karolinska University Hospital, 171 64 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oda","family":"Picard","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet, 171 77 Stockholm, Sweden"},{"name":"Department of Neonatology, Astrid Lindgren Children\u2019s Hospital, Karolinska University Hospital, 171 64 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5004-7881","authenticated-orcid":false,"given":"Joanna","family":"Ekstr\u00f6m","sequence":"additional","affiliation":[{"name":"Emergency Paediatric Emergency Medicine, Children\u2019s Minnesota, Minneapolis, MN 55404, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Chakhunashvili","sequence":"additional","affiliation":[{"name":"Department of IT Development and Healthcare Information Systems, Karolinska University Hospital, 171 64 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kajsa","family":"Bohlin","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Astrid Lindgren Children\u2019s Hospital, Karolinska University Hospital, 171 64 Stockholm, Sweden"},{"name":"Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 171 77 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Attner","sequence":"additional","affiliation":[{"name":"Sachs\u2019 Children and Youth Hospital, S\u00f6dersjukhuset, 118 83 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordana","family":"Printz","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Karolinska Institutet, 171 77 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Clinical Research Center and Department of Clinical Chemistry, Central Hospital, 652 30 Karlstad, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5742-411X","authenticated-orcid":false,"given":"Lilly-Ann","family":"Mohlkert","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 171 77 Stockholm, Sweden"},{"name":"Sachs\u2019 Children and Youth Hospital, S\u00f6dersjukhuset, 118 83 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonna","family":"Karl\u00e9n","sequence":"additional","affiliation":[{"name":"Sachs\u2019 Children and Youth Hospital, S\u00f6dersjukhuset, 118 83 Stockholm, Sweden"},{"name":"Department of Clinical Science and Education, Karolinska Institutet, S\u00f6dersjukhuset, 118 83 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Pegelow Halvorsen","sequence":"additional","affiliation":[{"name":"Sachs\u2019 Children and Youth Hospital, S\u00f6dersjukhuset, 118 83 Stockholm, Sweden"},{"name":"Department of Clinical Science and Education, Karolinska Institutet, S\u00f6dersjukhuset, 118 83 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Karin","family":"Edstedt Bonamy","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, 171 77 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jpeds.2017.05.024","article-title":"Changes in the Diagnosis and Management of Patent Ductus Arteriosus from 2006 to 2015 in United States Neonatal Intensive Care Units","volume":"189","author":"Bixler","year":"2017","journal-title":"J. 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