{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:39:06Z","timestamp":1791326346831,"version":"4.3.1"},"reference-count":58,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: Prader-Willi syndrome (PWS) is a rare genetic syndrome with a wide spectrum of clinical features in early life. Late diagnoses are still present. We characterized the perinatal and neonatal features of PWS, compared them with those of healthy newborns and assessed the prenatal and neonatal differences between the genetic subtypes. Design: A cohort study in children with PWS. The prevalence of variables was compared with healthy infants (PLUTO cohort) and to population statistics from literature. Patients: 244 infants with PWS and 365 healthy infants. Measurements: Data on prenatal and neonatal variables in both cohorts. Population statistics were collected through an extensive literature search. Results: A higher prevalence of maternal age &gt;35 years was found in PWS compared to healthy infants and population statistics, and the highest maternal age was found in the mUPD group. Higher prevalence of polyhydramnios, caesarean section, labour induction and breech presentation, and lower birth weight SDS was found in PWS compared to healthy infants. High prevalences of decreased fetal movements (78.5%), hypotonia (100%), cryptorchism (95.9%) and poor sucking\/tube feeding (93.9%) were found in PWS. Conclusions: This study presents an overview of prenatal and neonatal variables in infants with PWS compared to healthy infants. Our findings may increase clinical awareness of the early perinatal signs of PWS by obstetricians, neonatologists and all those involved in infant care, enabling early diagnosis and start of multidisciplinary treatment.<\/jats:p>","DOI":"10.3390\/jcm11030679","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T05:26:17Z","timestamp":1643433977000},"page":"679","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Prenatal and Neonatal Characteristics of Children with Prader-Willi Syndrome"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2410-9978","authenticated-orcid":false,"given":"Lionne N.","family":"Grootjen","sequence":"first","affiliation":[{"name":"Dutch Reference Center for Prader-Willi Syndrome Westzeedijk 106, 3016 AH Rotterdam, The Netherlands"},{"name":"Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center-Sophia Children\u2019s Hospital, 3015 CN Rotterdam, The Netherlands"},{"name":"Dutch Growth Research Foundation, 3016 AH Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie E. M.","family":"Uyl","sequence":"additional","affiliation":[{"name":"Dutch Growth Research Foundation, 3016 AH Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0204-7430","authenticated-orcid":false,"given":"Inge A. L. P.","family":"van Beijsterveldt","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center-Sophia Children\u2019s Hospital, 3015 CN Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layla","family":"Damen","sequence":"additional","affiliation":[{"name":"Dutch Reference Center for Prader-Willi Syndrome Westzeedijk 106, 3016 AH Rotterdam, The Netherlands"},{"name":"Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center-Sophia Children\u2019s Hospital, 3015 CN Rotterdam, The Netherlands"},{"name":"Dutch Growth Research Foundation, 3016 AH Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerthe F.","family":"Kerkhof","sequence":"additional","affiliation":[{"name":"Dutch Reference Center for Prader-Willi Syndrome Westzeedijk 106, 3016 AH Rotterdam, The Netherlands"},{"name":"Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center-Sophia Children\u2019s Hospital, 3015 CN Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita C. S.","family":"Hokken-Koelega","sequence":"additional","affiliation":[{"name":"Dutch Reference Center for Prader-Willi Syndrome Westzeedijk 106, 3016 AH Rotterdam, The Netherlands"},{"name":"Department of Pediatrics, Subdivision of Endocrinology, Erasmus University Medical Center-Sophia Children\u2019s Hospital, 3015 CN Rotterdam, The Netherlands"},{"name":"Dutch Growth Research Foundation, 3016 AH Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/gim.0b013e31822bead0","article-title":"Prader-Willi syndrome","volume":"14","author":"Cassidy","year":"2012","journal-title":"Genet. 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