{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:22:21Z","timestamp":1790421741427,"version":"4.1.0"},"reference-count":27,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The disorders of gut\u2013brain interaction (DGBI) have been associated with Fibromyalgia (FM). However, there are no data about the relationship between FM and DGBI using Rome IV criteria. This study aimed to evaluate the prevalence of FM in patients with Irritable Bowel Syndrome (IBS) and\/or Functional Dyspepsia (FD) and the prevalence of IBS and FD in FM patients using Rome IV criteria. DGBI patients and FM patients were recruited from two outpatient clinics devoted to DGBI and FM. All patients underwent a standardized gastrointestinal (GI) symptoms questionnaire. FM symptoms in DGBI patients were assessed through Fibromyalgia Rapid Screening Tool (FiRST) and Fibromyalgia Impact Questionnaire. Thereafter, the rheumatologists evaluated them. 49.0% of FM patients fulfilled the diagnostic criteria for IBS, 81.6% for FD with an overlap for both IBS\/FD in 44.9%. IBS-C was the most prevalent IBS-subtype in DGBI patients, whereas IBS-M was the most prevalent in FM patients (p = 0.01). 45.3% of DGBI patients reported pathological FiRST scores. DGBI patients with FM showed the highest score at the standardized GI questionnaire followed by FM patients with DGBI and DGBI without FM. In conclusion DGBI are common in FM patients and vice versa. The presence of FD is extremely frequent in FM patients. A multidisciplinary approach should be routinely used for the management of these patients.<\/jats:p>","DOI":"10.3390\/jcm11030809","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T11:35:17Z","timestamp":1643974517000},"page":"809","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Association among Disorders of Gut-Brain Interaction (DGBI) and Fibromyalgia: A Prospective Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8758-009X","authenticated-orcid":false,"given":"Carmela","family":"Settembre","sequence":"first","affiliation":[{"name":"Gastrointestinal Unit Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana\u201d, University of Salerno, 84081 Baronissi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"D\u2019Antonio","sequence":"additional","affiliation":[{"name":"Gastrointestinal Unit Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana\u201d, University of Salerno, 84081 Baronissi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Moscato","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, AOU San Giovanni di Dio e Ruggi d\u2019Aragona, 84125 Salerno, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Loi","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, AOU San Giovanni di Dio e Ruggi d\u2019Aragona, 84125 Salerno, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9094-765X","authenticated-orcid":false,"given":"Antonella","family":"Santonicola","sequence":"additional","affiliation":[{"name":"Gastrointestinal Unit Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana\u201d, University of Salerno, 84081 Baronissi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9568-0680","authenticated-orcid":false,"given":"Paola","family":"Iovino","sequence":"additional","affiliation":[{"name":"Gastrointestinal Unit Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana\u201d, University of Salerno, 84081 Baronissi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1053\/j.gastro.2016.02.032","article-title":"Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV","volume":"150","author":"Drossman","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.gtc.2021.03.006","article-title":"Behavioral Strategies for Irritable Bowel Syndrome: Brain-Gut or Gut-Brain?","volume":"50","author":"Jagielski","year":"2021","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1053\/j.gastro.2020.04.014","article-title":"Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study","volume":"160","author":"Sperber","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1136\/flgastro-2013-100426","article-title":"Prevalence of functional gastrointestinal disorders among consecutive new patient referrals to a gastroenterology clinic","volume":"5","author":"Shivaji","year":"2014","journal-title":"Frontline Gastroenterol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1038\/s41598-020-60318-6","article-title":"Irritable bowel, chronic widespread pain, chronic fatigue and related syndromes are prevalent and highly overlapping in the general population","volume":"10","author":"Petersen","year":"2020","journal-title":"DanFunD Sci. Rep."},{"key":"ref_6","first-page":"1685","article-title":"Chronic pain in Irritable Bowel Syndrome and other comorbid pain conditions","volume":"35","author":"Santonicola","year":"2019","journal-title":"Acta Med. Mediterr."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Siracusa, R., Paola, R.D., Cuzzocrea, S., and Impellizzeri, D. (2021). Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22083891"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1097\/00007632-199504000-00011","article-title":"Prevalence and treatment outcome of primary and secondary fibromyalgia in patients with spinal pain","volume":"20","author":"Borenstein","year":"1995","journal-title":"Spine"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3899\/jrheum.180083","article-title":"Primary and Secondary Fibromyalgia Are the Same: The Universality of Polysymptomatic Distress","volume":"46","author":"Wolfe","year":"2019","journal-title":"J. Rheumatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1111\/j.1572-0241.1999.01146.x","article-title":"Increased prevalence of sicca complex and fibromyalgia in patients with irritable bowel syndrome","volume":"94","author":"Barton","year":"1999","journal-title":"Am. J. Gastroenterol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1093\/rheumatology\/30.3.220","article-title":"Primary fibromyalgia and the irritable bowel syndrome: Different expressions of a common pathogenetic process","volume":"30","author":"Veale","year":"1991","journal-title":"Rheumatology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1111\/j.1572-0241.1999.01643.x","article-title":"Fibromyalgia in the irritable bowel syndrome: Studies of prevalence and clinical implications","volume":"94","author":"Sperber","year":"1999","journal-title":"Am. J. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1007\/s10620-006-3154-7","article-title":"Prevalence of irritable bowel syndrome and depression in fibromyalgia","volume":"51","author":"Kurland","year":"2006","journal-title":"Dig. Dis. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.cgh.2008.12.005","article-title":"Prevalence of functional gastrointestinal disorders in patients with fibromyalgia and the role of psychologic distress","volume":"7","author":"Almansa","year":"2009","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/art.1780330203","article-title":"The American College of Rheumatology Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee","volume":"33","author":"Wolfe","year":"1990","journal-title":"Arthritis Rheum."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e14092","DOI":"10.1111\/nmo.14092","article-title":"Impact of COVID-19 lockdown onsymptoms in patients with functional gastrointestinal disorders: Relationship with anxiety and perceived stress","volume":"33","author":"Oliviero","year":"2021","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3109\/00365528708991874","article-title":"Cisapride in non-ulcer dyspepsia. Results of a placebo-controlled trial","volume":"22","year":"1987","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.pain.2010.03.034","article-title":"Development and validation of the Fibromyalgia Rapid Screening Tool (FiRST)","volume":"150","author":"Perrot","year":"2010","journal-title":"Pain"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1093\/rheumatology\/kew244","article-title":"Performance of Fibromyalgia Rapid Screening Tool (FiRST) to detect fibromyalgia syndrome in rheumatic diseases","volume":"55","author":"Fan","year":"2016","journal-title":"Rheumatology"},{"key":"ref_20","first-page":"459","article-title":"Validation of an Italian version of the Fibromyalgia Impact Questionnaire (FIQ-I)","volume":"21","author":"Atzeni","year":"2003","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_21","first-page":"728","article-title":"The fibromyalgia impact questionnaire: Development and validation","volume":"18","author":"Burckhardt","year":"1991","journal-title":"J. Rheumatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s003840100299","article-title":"Fibromyalgia in patients with irritable bowel syndrome. An association with the severity of the intestinal disorder","volume":"16","author":"Lubrano","year":"2001","journal-title":"Int. J. Colorectal. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1756284820977402","DOI":"10.1177\/1756284820977402","article-title":"A systematic review of the association between fibromyalgia and functional gastrointestinal disorders","volume":"13","author":"Erdrich","year":"2020","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Tremolaterra, F., Gallotta, S., Morra, Y., Lubrano, E., Ciacci, C., and Iovino, P. (2014). The severity of irritable bowel syndrome or the presence of fibromyalgia influencing the perception of visceral and somatic stimuli. BMC Gastroenterol., 14.","DOI":"10.1186\/1471-230X-14-182"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/j.1572-0241.2006.00414.x","article-title":"Perception of electrocutaneous stimuli in irritable bowel syndrome","volume":"101","author":"Iovino","year":"2006","journal-title":"Am. J. Gastroenterol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neuroscience.2016.06.006","article-title":"Neurobiology of fibromyalgia and chronic widespread pain","volume":"338","author":"Sluka","year":"2016","journal-title":"Neuroscience"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00296-014-3109-9","article-title":"An insight into the gastrointestinal component of fibromyalgia: Clinical manifestations and potential underlying mechanisms","volume":"35","author":"Slim","year":"2015","journal-title":"Rheumatol. 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