{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:50:29Z","timestamp":1760151029302,"version":"build-2065373602"},"reference-count":27,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Coil embolization has become a well-established option for the treatment of intracranial aneurysms. Yet, wide-neck bifurcation aneurysms (WNBAs) remain a challenge. The pCONUS is the first generation of a stent-like implant for the bridging of WNBAs to enable coiling. The pToWin study was a prospective, single-arm, multicenter study conducted to analyze the safety and efficacy of the pCONUS in the treatment of WNBAs. The primary effectiveness endpoint was the rate of adequate occlusion of the aneurysm at 3\u20136 and 7\u201312 months. The primary safety endpoint was the occurrence of major ipsilateral stroke or neurological death during the follow-up. A total of 115 patients were included. Aneurysm locations were the middle cerebral artery in 52 (45.2%), the anterior communicating artery in 35 (30.4%), the basilar artery in 23 (20%), the internal carotid artery terminus in three (2.6%), and the pericallosal artery in two (1.7%) patients. Treatment was successfully performed in all but one patient. The morbi-mortality rate was 1.9% and 2.3% at 3\u20136 and 7\u201312 months, respectively. Of the aneurysms, 75.0% and 65.6% showed adequate occlusion at 3\u20136 and 7\u201312 months, respectively. pCONUS offers a safe and reasonably effective treatment of WNBAs, demonstrated by acceptable adequate aneurysm occlusion and low rates of adverse neurologic events.<\/jats:p>","DOI":"10.3390\/jcm11030884","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T23:37:48Z","timestamp":1644363468000},"page":"884","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Results of the pToWin Study: Using the pCONUS Device for the Treatment of Wide-Neck Intracranial Aneurysms"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3660-7467","authenticated-orcid":false,"given":"Marta","family":"Aguilar P\u00e9rez","sequence":"first","affiliation":[{"name":"Neuroradiological Clinic, Katharinenhospital Stuttgart, 70174 Stuttgart, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Henkes","sequence":"additional","affiliation":[{"name":"Neuroradiological Clinic, Katharinenhospital Stuttgart, 70174 Stuttgart, Germany"},{"name":"Medical Faculty, University of Duisburg-Essen, 45147 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wiebke","family":"Kurre","sequence":"additional","affiliation":[{"name":"Department of Radiology and Neuroradiology, Klinikum Passau, 94032 Passau, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2292-3263","authenticated-orcid":false,"given":"Carlos","family":"Bleise","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Cl\u00ednica La Sagrada Familia, Buenos Aires C1426EOB, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Nicol\u00e1s","family":"Lylyk","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Cl\u00ednica La Sagrada Familia, Buenos Aires C1426EOB, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Lundquist","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, Cl\u00ednica La Sagrada Familia, Buenos Aires C1426EOB, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Turjman","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, H\u00f4pital Pierre Wertheimer, 69500 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0316-2908","authenticated-orcid":false,"given":"Hanan","family":"Alhazmi","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, H\u00f4pital Pierre Wertheimer, 69500 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Loehr","sequence":"additional","affiliation":[{"name":"Department of Radiology and Neuroradiology, Klinikum Vest Knappschaftskrankenhaus Recklinghausen, 45657 Recklinghausen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Felber","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Neuroradiology, Gemeinschaftsklinikum Mittelrhein, 56068 Koblenz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannes","family":"Deutschmann","sequence":"additional","affiliation":[{"name":"Department of Radiology, Clinical Division of Neuroradiology, Vascular and Interventional Radiology, Medical Universtity Graz, 8063 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Lowens","sequence":"additional","affiliation":[{"name":"Department of Radiology, Klinikum Osnabr\u00fcck, 49076 Osnabruck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0447-847X","authenticated-orcid":false,"given":"Luigi","family":"Delehaye","sequence":"additional","affiliation":[{"name":"Unit of Interventional Neuroradiology, Ospedale San Giovanni Bosco, 80144 Napoli, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"M\u00f6hlenbruch","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Heidelberg University Hospital, 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Hattingen","sequence":"additional","affiliation":[{"name":"Institute of Neuroradiology, KRH Klinikum Nordstadt, 30167 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Lylyk","sequence":"additional","affiliation":[{"name":"Department of Interventional 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