{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:23:56Z","timestamp":1773833036623,"version":"3.50.1"},"reference-count":16,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The accumulation of contrast media in the kidneys might lead to contrast-induced acute kidney injury. In this prospective, controlled observational study, we aimed to evaluate whether forced diuresis with matched isotonic intravenous hydration prevents the accumulation of contrast media in the kidneys of patients undergoing cardiac interventional procedures. We compared the intensity of contrast media accumulation as observed in nephrograms following these procedures, with and without peri-procedural controlled renal flushing. The study group consisted of 25 patients with impaired renal function treated with the RenalGuard system. The two control groups included 25 patients with normal kidney function and 8 patients with impaired renal function undergoing similar procedures with routine pre-procedural hydration, but without controlled renal flushing. Renal contrast media accumulation at the end of each procedure was scored by blinded cardiologists. The renal contrast accumulation score (CAS) in the study group was significantly lower, with a median score of 0 (IQR (0\u20130)) compared with 1.5 (IQR (1\u20132)) in the normal renal function control group and 1 (IQR (0.38\u20131.62)) in the impaired renal function control group (p &lt; 0.001 and 0.003, respectively). In a multivariate analysis of CAS, RenalGuard treatment was independently associated with lower CAS compared to both control groups. In conclusion, RenalGuard use prevents renal contrast accumulation in patients with impaired renal function undergoing cardiac procedures with intra-arterial contrast media injection.<\/jats:p>","DOI":"10.3390\/jcm11030885","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T23:37:48Z","timestamp":1644363468000},"page":"885","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Forced Diuresis with Matched Isotonic Intravenous Hydration Prevents Renal Contrast Media Accumulation"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2978-6313","authenticated-orcid":false,"given":"Yael","family":"Ben-Haim","sequence":"first","affiliation":[{"name":"Department of Cardiology, Tel Aviv Medical Center, Tel Aviv 6423906, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehud","family":"Chorin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tel Aviv Medical Center, Tel Aviv 6423906, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9404-3145","authenticated-orcid":false,"given":"Aviram","family":"Hochstadt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tel Aviv Medical Center, Tel Aviv 6423906, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merav","family":"Ingbir","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"Internal Medicine Department, Tel Aviv Medical Center, Tel Aviv 6423906, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaron","family":"Arbel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tel Aviv Medical Center, Tel Aviv 6423906, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shafik","family":"Khoury","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tel Aviv Medical Center, Tel Aviv 6423906, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Halkin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tel Aviv Medical Center, Tel Aviv 6423906, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariel","family":"Finkelstein","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tel Aviv Medical Center, Tel Aviv 6423906, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shmuel","family":"Banai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tel Aviv Medical Center, Tel Aviv 6423906, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maayan","family":"Konigstein","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tel Aviv Medical Center, Tel Aviv 6423906, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1161\/01.CIR.0000016043.87291.33","article-title":"Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention","volume":"105","author":"Rihal","year":"2002","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcin.2013.06.016","article-title":"Contemporary incidence, predictors, and outcomes of acute kidney injury in patients undergoing percutaneous coronary interventions: Insights from the NCDR Cath-PCI registry","volume":"7","author":"Tsai","year":"2014","journal-title":"JACC Cardiovasc. 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Heart Assoc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1093\/eurheartj\/ehz343","article-title":"Forced diuresis with matched hydration during transcatheter aortic valve implantation for Reducing Acute Kidney Injury: A randomized, sham-controlled study (REDUCE-AKI)","volume":"40","author":"Arbel","year":"2019","journal-title":"Eur. Heart J."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/3\/885\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:15:56Z","timestamp":1760134556000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/3\/885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,8]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["jcm11030885"],"URL":"https:\/\/doi.org\/10.3390\/jcm11030885","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,8]]}}}