{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T13:08:54Z","timestamp":1768482534291,"version":"3.49.0"},"reference-count":76,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-11-IDEX-0004-02"],"award-info":[{"award-number":["ANR-11-IDEX-0004-02"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-COHO-10-01"],"award-info":[{"award-number":["ANR-10-COHO-10-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018375","name":"Fondation FondaMental","doi-asserted-by":"publisher","award":["RTRS Sant\u00e9 Mentale"],"award-info":[{"award-number":["RTRS Sant\u00e9 Mentale"]}],"id":[{"id":"10.13039\/100018375","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>In patients with bipolar disorder (BD), pain prevalence is close to 30%. It is important to determine whether pain influences BD course and to identify factors associated with pain in BD in order to guide BD management. This naturalistic, prospective study used data on 880 patients with BD from the French FACE-BD cohort who were divided into two groups according to the presence or absence of pain. Multivariate models were used to test whether pain was associated with affective states and personality traits while controlling for confounders. Then, multivariate models were used to test whether pain at baseline predicted global life functioning and depressive symptomatology at one year. At baseline, 22% of patients self-reported pain. The pain was associated with depressive symptomatology, levels of emotional reactivity in a quadratic relationship, and a composite variable of personality traits (affective lability, affective intensity, hostility\/anger, and impulsivity). At one year, the pain was predictive of depression and lower global life functioning. Pain worsens mental health and well-being in patients with BD. The role of emotions, depression, and personality traits in pain has to be elucidated to better understand the high prevalence of pain in BD and to promote specific therapeutic strategies for patients experiencing pain.<\/jats:p>","DOI":"10.3390\/jcm11030893","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T23:37:48Z","timestamp":1644363468000},"page":"893","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Self-Reported Pain and Emotional Reactivity in Bipolar Disorder: A Prospective FACE-BD Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9632-6077","authenticated-orcid":false,"given":"Nathan","family":"Risch","sequence":"first","affiliation":[{"name":"Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, 34094 Montpellier, France"},{"name":"Department of Emergency Psychiatry and Post-Acute Care, CHU Montpellier, 34295 Montpellier, France"},{"name":"Clinique de la Lironde, Clinea Psychiatrie, 34980 Saint-Cl\u00e9ment-de-Rivi\u00e8re, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Dubois","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, 34094 Montpellier, France"},{"name":"Department of Emergency Psychiatry and Post-Acute Care, CHU Montpellier, 34295 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia","family":"M\u2019bailara","sequence":"additional","affiliation":[{"name":"Fondation FondaMental, 94000 Cr\u00e9teil, France"},{"name":"LabPsy, University of Bordeaux, EA 4139, F-33000 Bordeaux, France"},{"name":"Department of Clinical and Academic Psychiatry, Charles-Perrens Hospital, 33076 Bordeaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Cussac","sequence":"additional","affiliation":[{"name":"Fondation FondaMental, 94000 Cr\u00e9teil, France"},{"name":"Psychiatric Center, Hospital Princesse Grace, 1 Ave. Pasteur, 98000 Monaco, Monaco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5377-1488","authenticated-orcid":false,"given":"Bruno","family":"Etain","sequence":"additional","affiliation":[{"name":"Fondation FondaMental, 94000 Cr\u00e9teil, France"},{"name":"AP-HP, GHU Paris Nord, DMU Neurosciences, H\u00f4pital Fernand Widal, 75010 Paris, France"},{"name":"INSERM UMRS 1144-Universit\u00e9 de Paris, 75006 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raoul","family":"Belzeaux","sequence":"additional","affiliation":[{"name":"Fondation FondaMental, 94000 Cr\u00e9teil, France"},{"name":"P\u00f4le de Psychiatrie, Assistance Publique H\u00f4pitaux de Marseille, 13005 Marseille, France"},{"name":"INT-UMR 7289, CNRS Aix-Marseille Universit\u00e9, 13385 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Dubertret","sequence":"additional","affiliation":[{"name":"Fondation FondaMental, 94000 Cr\u00e9teil, France"},{"name":"Department of Psychiatry, University of Paris, AP-HP, Louis Mourier Hospital, INSERM UMR 1266 Paris, 92700 Colombes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4091-518X","authenticated-orcid":false,"given":"Emmanuel","family":"Haffen","sequence":"additional","affiliation":[{"name":"Fondation FondaMental, 94000 Cr\u00e9teil, France"},{"name":"Service de Psychiatrie de l\u2019Adulte, CIC-1431 INSERM, CHU de Besan\u00e7on, Laboratoire de Neurosciences, Universit\u00e9 de Franche-Comt\u00e9, UBFC, 25000 Besan\u00e7on, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymund","family":"Schwan","sequence":"additional","affiliation":[{"name":"Fondation FondaMental, 94000 Cr\u00e9teil, France"},{"name":"Universit\u00e9 de Lorraine, Centre Psychoth\u00e9rapique de Nancy, P\u00f4le Hospitalo-Universitaire de Psychiatrie d\u2019Adultes du Grand Nancy, INSERM U1254, 54000 Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludovic","family":"Samalin","sequence":"additional","affiliation":[{"name":"Fondation FondaMental, 94000 Cr\u00e9teil, France"},{"name":"CHU Clermont-Ferrand, Department of Psychiatry, University of Clermont Auvergne, UMR 6602 Institut Pascal (IP), 63178 Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0321-4189","authenticated-orcid":false,"given":"Paul","family":"Roux","sequence":"additional","affiliation":[{"name":"Fondation FondaMental, 94000 Cr\u00e9teil, France"},{"name":"Centre Hospitalier de Versailles, Service de Psychiatrie et D\u2019addictologie Adulte, Le Chesnay, EA 4047 HANDIReSP, UFR des Sciences de la Sant\u00e9 Simone Veil, Universit\u00e9 Versailles Saint-Quentin-en-Yvelines, Versailles, France and Universit\u00e9 Paris-Saclay, UVSQ, Inserm, CESP, Equipe \u201cPsyDev\u201d, 94807 Villejuif, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mircea","family":"Polosan","sequence":"additional","affiliation":[{"name":"Fondation FondaMental, 94000 Cr\u00e9teil, France"},{"name":"Universit\u00e9 Grenoble Alpes, Inserm U1216, Grenoble Institut de Neurosciences, CHU de Grenoble, F-38000 Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5473-3697","authenticated-orcid":false,"given":"Marion","family":"Leboyer","sequence":"additional","affiliation":[{"name":"Fondation FondaMental, 94000 Cr\u00e9teil, France"},{"name":"Universit\u00e9 Paris Est Creteil (UPEC), AP-HP, H\u00f4pitaux Universitaires \u00abH. Mondor\u00bb, DMU IMPACT, INSERM, IMRB, Translational Neuropsychiatry, Fondation FondaMental, F-94010 Creteil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Courtet","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, 34094 Montpellier, France"},{"name":"Department of Emergency Psychiatry and Post-Acute Care, CHU Montpellier, 34295 Montpellier, France"},{"name":"Fondation FondaMental, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie","family":"Oli\u00e9","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, 34094 Montpellier, France"},{"name":"Department of Emergency Psychiatry and Post-Acute Care, CHU Montpellier, 34295 Montpellier, France"},{"name":"Fondation FondaMental, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.4088\/JCP.14m09038","article-title":"Metabolic Syndrome in a French Cohort of Patients with Bipolar Disorder: Results From the FACE-BD Cohort","volume":"75","author":"Godin","year":"2014","journal-title":"J. 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