{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T03:06:37Z","timestamp":1776481597437,"version":"3.51.2"},"reference-count":334,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The cardiovascular system and the central nervous system (CNS) closely cooperate in the regulation of primary vital functions. The autonomic nervous system and several compounds known as cardiovascular factors, especially those targeting the renin\u2013angiotensin system (RAS), the vasopressin system (VPS), and the oxytocin system (OTS), are also efficient modulators of several other processes in the CNS. The components of the RAS, VPS, and OTS, regulating pain, emotions, learning, memory, and other cognitive processes, are present in the neurons, glial cells, and blood vessels of the CNS. Increasing evidence shows that the combined function of the RAS, VPS, and OTS is altered in neuropsychiatric\/neurodegenerative diseases, and in particular in patients with depression, Alzheimer\u2019s disease, Parkinson\u2019s disease, autism, and schizophrenia. The altered function of the RAS may also contribute to CNS disorders in COVID-19. In this review, we present evidence that there are multiple causes for altered combined function of the RAS, VPS, and OTS in psychiatric and neurodegenerative disorders, such as genetic predispositions and the engagement of the RAS, VAS, and OTS in the processes underlying emotions, memory, and cognition. The neuroactive pharmaceuticals interfering with the synthesis or the action of angiotensins, vasopressin, and oxytocin can improve or worsen the effectiveness of treatment for neuropsychiatric\/neurodegenerative diseases. Better knowledge of the multiple actions of the RAS, VPS, and OTS may facilitate programming the most efficient treatment for patients suffering from the comorbidity of neuropsychiatric\/neurodegenerative and cardiovascular diseases.<\/jats:p>","DOI":"10.3390\/jcm11040908","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T21:22:15Z","timestamp":1644441735000},"page":"908","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Multiple Aspects of Inappropriate Action of Renin\u2013Angiotensin, Vasopressin, and Oxytocin Systems in Neuropsychiatric and Neurodegenerative Diseases"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3761-508X","authenticated-orcid":false,"given":"Ewa","family":"Szczepanska-Sadowska","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7221-8103","authenticated-orcid":false,"given":"Agnieszka","family":"Wsol","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3872-291X","authenticated-orcid":false,"given":"Agnieszka","family":"Cudnoch-Jedrzejewska","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Czarzasta","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3535-715X","authenticated-orcid":false,"given":"Tymoteusz","family":"\u017bera","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Physiology, Laboratory of Centre for Preclinical Research, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global Burden of Cardiovascular Diseases and Risk Factors, 1990\u20132019: Update From the GBD 2019 Study","volume":"76","author":"Roth","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e000037","DOI":"10.1161\/HCG.0000000000000037","article-title":"Expressed Genome in Cardiovascular Diseases and Stroke: Refinement, Diagnosis, and Prediction: A Scientific Statement From the American Heart Association","volume":"10","author":"Musunuru","year":"2017","journal-title":"Circ. Cardiovasc. Genet."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/wps.20420","article-title":"Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: A large-scale meta-analysis of 3,211,768 patients and 113,383,368 controls","volume":"16","author":"Correll","year":"2017","journal-title":"World Psychiatry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1113\/JP271869","article-title":"Translational neurocardiology: Preclinical models and cardioneural integrative aspects","volume":"594","author":"Ardell","year":"2016","journal-title":"J. Physiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.jacc.2007.12.024","article-title":"Psychological stress and cardiovascular disease","volume":"51","author":"Dimsdale","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1159\/000350094","article-title":"Molecular mechanisms of depression: Perspectives on new treatment strategies","volume":"31","author":"Lang","year":"2013","journal-title":"Cell Physiol. Biochem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"531763","DOI":"10.3389\/fnins.2020.531763","article-title":"Antipsychotic Treatment Failure: A Systematic Review on Risk Factors and Interventions for Treatment Adherence in Psychosis","volume":"14","author":"Morrens","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.regpep.2009.02.002","article-title":"Endogenous angiotensinergic system in neurons of rat and human trigeminal ganglia","volume":"154","author":"Imboden","year":"2009","journal-title":"Regul. Pept."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s40263-013-0054-1","article-title":"Antipsychotic-induced metabolic and cardiovascular side effects in schizophrenia: A novel mechanistic hypothesis","volume":"27","author":"Scigliano","year":"2013","journal-title":"CNS Drugs"},{"key":"ref_10","first-page":"509","article-title":"Brain and cardiovascular diseases: Common neurogenic background of cardiovascular, metabolic and inflammatory diseases","volume":"61","author":"Ufnal","year":"2010","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41581-018-0018-2","article-title":"The gut microbiota and the brain-gut-kidney axis in hypertension and chronic kidney disease","volume":"14","author":"Yang","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"6333","DOI":"10.1073\/pnas.0401510101","article-title":"The human cortex responds to an interoceptive challenge","volume":"101","author":"Critchley","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neubiorev.2010.02.001","article-title":"Brain reward circuitry beyond the mesolimbic dopamine system: A neurobiological theory","volume":"35","author":"Ikemoto","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/jne.12272","article-title":"The Medial Prefrontal Cortex: Coordinator of Autonomic, Neuroendocrine, and Behavioral Responses to Stress","volume":"27","author":"McKlveen","year":"2015","journal-title":"J. Neuroendocrinol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cmet.2017.09.021","article-title":"Overlapping brain circuits for homeostatic and hedonic feeding","volume":"27","author":"Rossi","year":"2018","journal-title":"Cell Metab."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11906-018-0823-9","article-title":"Dysregulation of the renin-angiotensin system and the vasopressinergic system; interactions in cardiovascular disorders","volume":"20","author":"Czarzasta","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"102046","DOI":"10.1016\/j.npep.2020.102046","article-title":"Differential role of specific cardiovascular neuropeptides in pain regulation: Relevance to cardiovascular diseases","volume":"81","author":"Sadowski","year":"2020","journal-title":"Neuropeptides"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/wps.20187","article-title":"Cardiovascular and cerebrovascular risk factors and events associated with second-generation antipsychotic compared to antidepressant use in a non-elderly adult sample: Results from a claims-based inception cohort study","volume":"14","author":"Correll","year":"2015","journal-title":"World Psychiatry"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.nbd.2011.10.025","article-title":"Cardiovascular dysautonomia in Parkinson Disease: From pathophysiology to pathogenesis","volume":"46","author":"Jain","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/MOG.0b013e328342a6ea","article-title":"Enteric nervous system neuropathy: Repair and restoration","volume":"27","author":"Wood","year":"2011","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/978-3-319-27592-5_17","article-title":"Enteric neurobiology: Discoveries and directions","volume":"891","author":"Wood","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1196\/annals.1410.006","article-title":"Peripherally administered angiotensin II AT1 receptor antagonists are anti-stress compounds in vivo","volume":"1148","author":"Pavel","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/10253890701350735","article-title":"Brain and peripheral angiotensin II play a major role in stress","volume":"10","author":"Saavedra","year":"2007","journal-title":"Stress"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psyneuen.2010.10.001","article-title":"Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implications","volume":"36","author":"Saavedra","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1080\/10253890701794445","article-title":"Differential sensitisation to central cardiovascular effects of angiotensin II in rats with a myocardial infarct: Relevance to stress and interaction with vasopressin","volume":"11","author":"Dobruch","year":"2008","journal-title":"Stress"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1080\/10253890500456287","article-title":"Enhanced involvement of brain vasopressin V1 receptors in cardiovascular responses to stress in rats with myocardial infarction","volume":"8","author":"Dobruch","year":"2005","journal-title":"Stress"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.brainres.2006.04.122","article-title":"Centrally administered interleukin-1 beta sensitizes to the central pressor action of angiotensin II","volume":"1100","author":"Ufnal","year":"2006","journal-title":"Brain Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1097\/01.nmd.0000221177.51089.7d","article-title":"Extent and management of cardiovascular risk factors in patients with type 2 diabetes and serious mental illness","volume":"194","author":"Kreyenbuhl","year":"2006","journal-title":"J. Nerv. Ment. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"586314","DOI":"10.3389\/fnins.2020.586314","article-title":"Brain Renin-Angiotensin System at the Intersect of Physical and Cognitive Frailty","volume":"14","author":"Cosarderelioglu","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1113\/expphysiol.2009.047407","article-title":"Angiotensin-converting enzyme 2: A new target for neurogenic hypertension","volume":"95","author":"Feng","year":"2010","journal-title":"Exp. Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S1357-2725(02)00306-0","article-title":"The brain renin-angiotensin system: Location and physiological roles","volume":"35","author":"McKinley","year":"2003","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1152\/physrev.00036.2005","article-title":"Physiology of local renin-angiotensin systems","volume":"86","author":"Paul","year":"2006","journal-title":"Physiol. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3389\/fnagi.2017.00129","article-title":"Brain renin-angiotensin System and microglial polarization: Implications for aging and neurodegeneration","volume":"9","author":"Lanciego","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1161\/hy1201.099611","article-title":"Oxidative stress in arterial hypertension: Role of NAD(P)H oxidase","volume":"38","author":"Zalba","year":"2001","journal-title":"Hypertension"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1161\/01.HYP.33.2.613","article-title":"Recent progress in angiotensin II type 2 receptor research in the cardiovascular system","volume":"33","author":"Horiuchi","year":"1999","journal-title":"Hypertension"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neuroscience.2009.06.032","article-title":"Angiotensin II type 2 receptors have a major somatodendritic distribution in vasopressin-containing neurons in the mouse hypothalamic paraventricular nucleus","volume":"63","author":"Coleman","year":"2009","journal-title":"Neuroscience"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/s12974-020-01908-z","article-title":"Angiotensin AT1 and AT2 receptor heteromer expression in the hemilesioned rat model of Parkinson\u2019s disease that increases with levodopa-induced dyskinesia","volume":"17","author":"Navarro","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"48623","DOI":"10.1074\/jbc.C100512200","article-title":"Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin-regulated aminopeptidase","volume":"276","author":"Albiston","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1124\/jpet.114.218735","article-title":"The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor\/c-met system","volume":"351","author":"Benoist","year":"2014","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"5847","DOI":"10.1007\/s12035-017-0805-y","article-title":"Paracrine and intracrine angiotensin 1-7\/Mas receptor axis in the substantia nigra of rodents, monkeys, and humans","volume":"55","author":"Valenzuela","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.lfs.2008.07.003","article-title":"Human brain contains a novel non-AT1, non-AT2 binding site for active angiotensin peptides","volume":"83","author":"Karamyan","year":"2008","journal-title":"Life Sci."},{"key":"ref_42","first-page":"101919","article-title":"The intracellular renin-angiotensin system: Friend or foe. Some light from the dopaminergic neurons","volume":"8","author":"Valenzuela","year":"2020","journal-title":"Prog. Neurobiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1113\/expphysiol.2013.074591","article-title":"Upregulation of a local renin-angiotensin system in the rat carotid body during chronic intermittent hypoxia","volume":"99","author":"Lam","year":"2014","journal-title":"Exp. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00109-008-0331-5","article-title":"Brain renin angiotensin in disease","volume":"86","author":"Phillips","year":"2008","journal-title":"J. Mol. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00441-006-0190-8","article-title":"The CNS renin-angiotensin system","volume":"326","author":"Halbach","year":"2006","journal-title":"Cell Tissue Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0167-0115(93)90251-3","article-title":"The renin-angiotensin system in the brain: An update 1993","volume":"46","author":"Bunnemann","year":"1993","journal-title":"Regul. Pept."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1161\/CIRCRESAHA.110.226977","article-title":"Involvement of the brain (pro)renin receptor in cardiovascular homeostasis","volume":"107","author":"Shan","year":"2010","journal-title":"Circ. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"H1216","DOI":"10.1152\/ajpheart.00557.2008","article-title":"Interaction between cardiac sympathetic afferent reflex and chemoreflex is mediated by the NTS AT1 receptors in heart failure","volume":"295","author":"Wang","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1007\/s13311-020-00986-4","article-title":"Novel Interactions Involving the Mas Receptor Show Potential of the Renin-Angiotensin System in the Regulation of Microglia Activation: Altered Expression in Parkinsonism and Dyskinesia","volume":"18","author":"Lillo","year":"2021","journal-title":"Neurotherapeutics"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s13311-018-0646-z","article-title":"Angiotensin type 1 receptor antagonists protect against alpha-synuclein-induced neuroinflammation and dopaminergic neuron death","volume":"15","author":"Sucunza","year":"2018","journal-title":"Neurotherapeutics"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.bbi.2019.12.011","article-title":"Angiotensin type 2 receptors: Role in aging and neuroinflammation in the substantia nigra","volume":"87","author":"Pedrosa","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.npep.2005.08.001","article-title":"Blockade of angiotensin II AT1 receptors inhibits pressor action of centrally administered interleukin-1beta in Sprague Dawley rats","volume":"39","author":"Ufnal","year":"2005","journal-title":"Neuropeptides"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neulet.2008.10.010","article-title":"Interleukin-1 receptor antagonist reduces the magnitude of the pressor response to acute stress","volume":"448","author":"Ufnal","year":"2008","journal-title":"Neurosci. Lett."},{"key":"ref_54","first-page":"117","article-title":"Central TNF-alpha elevates blood pressure and sensitizes to central pressor action of angiotensin II in the infarcted rats","volume":"59","author":"Zera","year":"2008","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1161\/01.RES.86.5.494","article-title":"NAD(P)H oxidase: Role in cardiovascular biology and disease","volume":"86","author":"Griendling","year":"2000","journal-title":"Circ. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11906-018-0810-1","article-title":"Integrative Physiological Aspects of Brain RAS in Hypertension","volume":"20","author":"Shanks","year":"2018","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0306-4522(88)90029-2","article-title":"Immunocytochemical localization of angiotensinogen in the rat brain","volume":"25","author":"Thomas","year":"1988","journal-title":"Neuroscience"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0006-8993(98)01236-0","article-title":"The angiotensinogen gene is expressed in both astrocytes and neurons in murine central nervous system","volume":"817","author":"Yang","year":"1999","journal-title":"Brain Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1113\/jphysiol.2014.276584","article-title":"Mineralocorticoid and AT1 receptors in the paraventricular nucleus contribute to sympathetic hyperactivity and cardiac dysfunction in rats post myocardial infarct","volume":"592","author":"Huang","year":"2014","journal-title":"J. Physiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/0006-291X(92)91680-O","article-title":"Differential expression of angiotensin II receptor subtype mRNAs (AT-1A and AT-1B) in the brain","volume":"185","author":"Kakar","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0169-328X(95)00160-T","article-title":"Comparative expression of vasopressin and angiotensin type-1 receptor mRNA in rat hypothalamic nuclei: A double in situ hybridization study","volume":"34","author":"Lenkei","year":"1995","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0167-0115(98)00109-8","article-title":"Mapping of angiotensin AT1 receptors in the rat limbic system","volume":"78","author":"Albrecht","year":"1998","journal-title":"Regul. Pept."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"H2271","DOI":"10.1152\/ajpheart.00949.2004","article-title":"Sympathoexcitation by central ANG II: Roles for AT1 receptor upregulation and NAD(P)H oxidase in RVLM","volume":"288","author":"Gao","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1161\/HYPERTENSIONAHA.108.116228","article-title":"Imbalance of angiotensin type 1 receptor and angiotensin II type 2 receptor in the rostral ventrolateral medulla: Potential mechanism for sympathetic overactivity in heart failure","volume":"52","author":"Gao","year":"2008","journal-title":"Hypertension"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0306-4522(03)00606-7","article-title":"Angiotensin II subtype 1A (AT1A) receptors in the rat sensory vagal complex: Subcellular localization and association with endogenous angiotensin","volume":"122","author":"Huang","year":"2003","journal-title":"Neuroscience"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.npep.2014.07.004","article-title":"Altered expression of V1a receptors mRNA in the brain and kidney after myocardial infarction and chronic stress","volume":"48","author":"Milik","year":"2014","journal-title":"Neuropeptides"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/PSY.0000000000000269","article-title":"Effect of chronic mild stress on AT1 receptor messenger RNA expression in the brain and kidney of rats","volume":"78","author":"Milik","year":"2016","journal-title":"Psychosom. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e12703","DOI":"10.1111\/jne.12703","article-title":"Whole body sodium depletion modifies AT1 mRNA expression and serotonin content in the dorsal raphe nucleus","volume":"31","author":"Porcari","year":"2019","journal-title":"J. Neuroendocrinol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e2427","DOI":"10.1038\/cddis.2016.327","article-title":"Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration","volume":"7","author":"Valenzuela","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1161\/01.HYP.0000259942.38108.20","article-title":"Overexpression of angiotensin-converting enzyme 2 in the rostral ventrolateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive rats","volume":"49","author":"Yamazato","year":"2007","journal-title":"Hypertension"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"H1416","DOI":"10.1152\/ajpheart.00141.2007","article-title":"Immunofluorescence localization of the receptor Mas in cardiovascular-related areas of the rat brain","volume":"293","author":"Becker","year":"2007","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1159\/000211202","article-title":"Angiotensinergic regulation of autonomic and neuroendocrine outputs: Critical roles for the subfornical organ and paraventricular nucleus","volume":"89","author":"Ferguson","year":"2009","journal-title":"Neuroendocrinology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"913","DOI":"10.3109\/10641969709083195","article-title":"Effect of central endogenous angiotensin II on sympathetic activation induced by hypoxia","volume":"19","author":"Gaudet","year":"1997","journal-title":"Clin. Exp. Hypertens."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"H496","DOI":"10.1152\/ajpheart.00063.2019","article-title":"Exacerbated effects of prorenin on hypothalamic magnocellular neuronal activity and vasopressin plasma levels during salt-sensitive hypertension","volume":"317","author":"Pitra","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0006-8993(03)03112-3","article-title":"Angiotensin type 1 receptor immunoreactivity in the thoracic spinal cord","volume":"985","author":"Ahmad","year":"2003","journal-title":"Brain Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"F559","DOI":"10.1152\/ajprenal.90399.2008","article-title":"Aldosterone in the brain","volume":"297","author":"Geerling","year":"2009","journal-title":"Am. J. Physiol.-Renal Physiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/HYPERTENSIONAHA.113.01557","article-title":"Role of brain corticosterone and aldosterone in central angiotensin II-induced hypertension","volume":"62","author":"Huang","year":"2013","journal-title":"Hypertension"},{"key":"ref_78","first-page":"H167","article-title":"Evidence that centrally released arginine vasopressin is involved in central pressor action of angiotensin II","volume":"270","author":"Szczypaczewska","year":"1996","journal-title":"Am. J. Physiol."},{"key":"ref_79","first-page":"H1918","article-title":"Role of central AT1 and V1 receptors in cardiovascular adaptation to hemorrhage in SD and renin TGR rats","volume":"276","author":"Paczwa","year":"1999","journal-title":"Am. J. Physiol."},{"key":"ref_80","first-page":"829","article-title":"Aldosterone and mineralocorticoid receptors in regulation of the cardiovascular system and pathological remodelling of the heart and arteries","volume":"69","author":"Sztechman","year":"2018","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/ajh.2010.103","article-title":"Simvastatin reduces pressor response to centrally administered angiotensin II","volume":"23","author":"Ufnal","year":"2010","journal-title":"Am. J. Hypertens."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"H1067","DOI":"10.1152\/ajpheart.01131.2007","article-title":"Aldosterone acts centrally to increase brain renin-angiotensin system activity and oxidative stress in normal rats","volume":"294","author":"Zhang","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"H1557","DOI":"10.1152\/ajpheart.00073.2009","article-title":"Regulation of central angiotensin type 1 receptors and sympathetic outflow in heart failure","volume":"297","author":"Zucker","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.cyto.2014.10.019","article-title":"TNF and angiotensin type 1 receptors interact in the brain control of blood pressure in heart failure","volume":"71","author":"Ufnal","year":"2015","journal-title":"Cytokine"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.regpep.2007.01.010","article-title":"Interaction of AT1 receptors and V1a receptors-mediated effects in the central cardiovascular control during the post-infarct state","volume":"142","author":"Dobruch","year":"2007","journal-title":"Regul. Pept."},{"key":"ref_86","first-page":"385082","article-title":"Angiotensin converting enzyme inhibition reduces cardiovascular responses to acute stress in myocardially infarcted and chronically stressed rats","volume":"2014","author":"Czarzasta","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/cvr\/cvs420","article-title":"Inhibition of brain angiotensin III attenuates sympathetic hyperactivity and cardiac dysfunction in rats post-myocardial infarction","volume":"97","author":"Huang","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.brainres.2008.11.006","article-title":"A peripherally administered, centrally acting angiotensin II AT2 antagonist selectively increases brain AT1 receptors and decreases brain tyrosine hydroxylase transcription, pituitary vasopressin and ACTH","volume":"1250","author":"Macova","year":"2009","journal-title":"Brain Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"C561","DOI":"10.1152\/ajpcell.00127.2010","article-title":"Angiotensin II-induced upregulation of AT(1) receptor expression: Sequential activation of NF-kappaB and Elk-1 in neurons","volume":"299","author":"Mitra","year":"2010","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1177\/1470320310394891","article-title":"Chronic angiotensin II infusion modulates angiotensin II type I receptor expression in the subfornical organ and the rostral ventrolateral medulla in hypertensive rats","volume":"12","author":"Nunes","year":"2011","journal-title":"J. Renin-Angiotensin-Aldosterone Syst."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1161\/HYPERTENSIONAHA.108.113639","article-title":"Mitogen-activated protein kinases mediate upregulation of hypothalamic AT1 receptors in heart failure rats","volume":"52","author":"Wei","year":"2008","journal-title":"Hypertension"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1152\/physiolgenomics.00029.2016","article-title":"Angiotensin type 1a receptors in the paraventricular nucleus of the hypothalamus control cardiovascular reactivity and anxiety-like behavior in male mice","volume":"48","author":"Wang","year":"2016","journal-title":"Physiol. Genomics"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1523\/JNEUROSCI.5360-11.2012","article-title":"Angiotensin type 1A receptors in C1 neurons of the rostral ventrolateral medulla modulate the pressor response to aversive stress","volume":"32","author":"Chen","year":"2012","journal-title":"J. Neurosci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/npp.2010.225","article-title":"Angiotensin II AT1 Receptor Blockade Ameliorates Brain Inflammation","volume":"36","author":"Benicky","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"ref_95","first-page":"371","article-title":"Hypotensive function of the brain angiotensin-(1-7) in Sprague Dawley and renin transgenic rats","volume":"54","author":"Dobruch","year":"2003","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Xia, H., Suda, S., Bindom, S., Feng, Y., Gurley, S.B., Seth, D., Navar, L.G., and Lazartigues, E. (2011). ACE2-mediated reduction of oxidative stress in the central nervous system is associated with improvement of autonomic function. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0022682"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"R370","DOI":"10.1152\/ajpregu.00366.2014","article-title":"Brain ACE2 overexpression reduces DOCA-salt hypertension independently of endoplasmic reticulum stress","volume":"308","author":"Xia","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1001\/archinternmed.2009.175","article-title":"Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: Results from the Cardiovascular Health Study","volume":"169","author":"Sink","year":"2009","journal-title":"Arch. Intern. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3233\/JAD-200118","article-title":"Angiotensin II Blood Levels Are Associated with Smaller Hippocampal and Cortical Volumes in Cognitively Normal Older Adults","volume":"75","author":"Yasar","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.bbrc.2014.04.153","article-title":"Prophylactic angiotensin type 1 receptor antagonism confers neuroprotection in an aged rat model of postoperative cognitive dysfunction","volume":"449","author":"Li","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2165\/00129784-200505040-00004","article-title":"Neuroprotection with angiotensin receptor antagonists: A review of the evidence and potential mechanisms","volume":"5","author":"Wilms","year":"2005","journal-title":"Am. J. Cardiovasc. Drugs"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.pharep.2013.11.002","article-title":"Telmisartan attenuates cognitive impairment caused by chronic stress in rats","volume":"66","author":"Wincewicz","year":"2014","journal-title":"Pharmacol. Rep."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3317\/jraas.2006.027","article-title":"Cognitive effects attributed to angiotensin II may result from its conversion to angiotensin IV","volume":"7","author":"Braszko","year":"2006","journal-title":"J. Renin-Angiotensin-Aldosterone Syst."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3233\/JAD-181000","article-title":"Chronic Angiotensin 1-7 Infusion Prevents Angiotensin-II-Induced Cognitive Dysfunction and Skeletal Muscle Injury in a Mouse Model of Alzheimer\u2019s Disease","volume":"69","author":"Cao","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.mcn.2005.03.012","article-title":"Angiotensin-(1-7) enhances LTP in the hippocampus through the G-protein-coupled receptor Mas","volume":"29","author":"Hellner","year":"2005","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/00005344-199008000-00009","article-title":"Angiotensin II inhibits cortical cholinergic function: Implications for cognition","volume":"16","author":"Barnes","year":"1990","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0014-2999(91)90584-D","article-title":"Angiotensin converting enzyme density is increased in temporal cortex from patients with Alzheimer\u2019s disease","volume":"200","author":"Barnes","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0197-4580(00)00259-1","article-title":"Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer\u2019s dementia","volume":"22","author":"Savaskan","year":"2001","journal-title":"Neurobiol. Aging"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1089\/ars.2012.5027","article-title":"Amyloid \u03b2-peptide (1-42)-induced oxidative stress in Alzheimer disease: Importance in disease pathogenesis and progression","volume":"19","author":"Butterfield","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3389\/fendo.2012.00164","article-title":"How does angiotensin AT(2) receptor activation help neuronal differentiation and improve neuronal pathological situations?","volume":"3","author":"Guimond","year":"2012","journal-title":"Front. Endocrinol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1073\/pnas.82.12.4245","article-title":"Amyloid plaque core protein in Alzheimer disease and Down syndrome","volume":"82","author":"Masters","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"104230","DOI":"10.1016\/j.phrs.2019.04.014","article-title":"Improvements of symptoms of Alzheimer\u2019s disease by inhibition of the angiotensin system","volume":"154","author":"Quitterer","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1161\/HYPERTENSIONAHA.109.138586","article-title":"Angiotensin receptor blocker prevented beta amyloid-induced cognitive impairment associated with recovery of neurovascular coupling","volume":"54","author":"Takeda","year":"2009","journal-title":"Hypertension"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1007\/s12035-015-9260-9","article-title":"Angiotensin-(1-7) is Reduced and Inversely Correlates with Tau Hyperphosphorylation in Animal Models of Alzheimer\u2019s Disease","volume":"53","author":"Jiang","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/j.1365-2826.1995.tb00714.x","article-title":"Increased expression of type 1 angiotensin II receptors in the hypothalamic paraventricular nucleus following stress and glucocorticoid administration","volume":"7","author":"Aguilera","year":"1995","journal-title":"J. Neuroendocrinol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10571-017-0518-9","article-title":"AT1 and AT2 receptors in the prelimbic cortex modulate the cardiovascular response evoked by acute exposure to restraint stress in rats","volume":"38","author":"Brasil","year":"2018","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000336340","article-title":"Angiotensin-(1\u20137) induces peripheral antinociception through Mas receptor activation in an opioid-independent pathway","volume":"89","author":"Costa","year":"2012","journal-title":"Pharmacology"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.3892\/etm.2015.2801","article-title":"Chronic nerve injury-induced Mas receptor expression in dorsal root ganglion neurons alleviates neuropathic pain","volume":"10","author":"Zhao","year":"2015","journal-title":"Exp. Ther. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.pnpbp.2007.04.002","article-title":"Renin-angiotensin-system gene polymorphisms and depression","volume":"31","author":"Saab","year":"2007","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bbr.2013.09.003","article-title":"Angiotensin-(1-7) attenuates the anxiety and depression-like behaviors in transgenic rats with low brain angiotensinogen","volume":"257","author":"Kangussu","year":"2013","journal-title":"Behav. Brain Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1111\/j.1532-5415.2010.02860.x","article-title":"Renin angiotensin system gene polymorphisms modify angiotensin-converting enzyme inhibitors\u2019 effect on cognitive function: The health, aging and body composition study","volume":"58","author":"Hajjar","year":"2010","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1002\/phar.1968","article-title":"Cardiovascular Pharmacogenomics and Cognitive Function in Patients with Schizophrenia","volume":"37","author":"Ward","year":"2017","journal-title":"Pharmacotherapy"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e691","DOI":"10.1038\/tp.2015.181","article-title":"Convergent evidences from human and animal studies implicate angiotensin I-converting enzyme activity in cognitive performance in schizophrenia","volume":"5","author":"Gadelha","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/acps.12799","article-title":"The effect of adjunctive telmisartan treatment on psychopathology and cognition in patients with schizophrenia","volume":"136","author":"Fan","year":"2017","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.neuropharm.2013.07.016","article-title":"Effect of chronic treatment with angiotensin type 1 receptor antagonists on striatal dopamine levels in normal rats and in a rat model of Parkinson\u2019s disease treated with L-DOPA","volume":"76","author":"Guerra","year":"2014","journal-title":"Neuropharmacology"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1471-4159.2009.05999.x","article-title":"The inflammatory response in the MPTP model of Parkinson\u2019s disease is mediated by brain angiotensin: Relevance to progression of the disease","volume":"109","author":"Joglar","year":"2009","journal-title":"J. Neurochem."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.expneurol.2013.10.014","article-title":"The angiotensin converting enzyme inhibitor captopril protects nigrostriatal dopamine neurons in animal models of parkinsonism","volume":"250","author":"Sonsalla","year":"2013","journal-title":"Exp. Neurol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1177\/1470320313515038","article-title":"Beneficial effect of candesartan and lisinopril against haloperidol-induced tardive dyskinesia in rat","volume":"16","author":"Thakur","year":"2015","journal-title":"J. Renin-Angiotensin-Aldosterone Syst."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13195-021-00850-3","article-title":"Network medicine links SARS-CoV-2\/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment","volume":"13","author":"Zhou","year":"2021","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1001\/archpsyc.1996.01830020055007","article-title":"Increased number of vasopressin- and oxytocin-expressing neurons in the paraventricular nucleus of the hypothalamus in depression","volume":"53","author":"Purba","year":"1996","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/sj.mp.4001420","article-title":"A major SNP haplotype of the arginine vasopressin 1B receptor protects against recurrent major depression","volume":"9","author":"Aulchenko","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.psychres.2012.07.031","article-title":"Possible genetic association between vasopressin receptor 1B and child aggression","volume":"200","author":"Zai","year":"2012","journal-title":"Psychiatry Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1038\/npp.2013.49","article-title":"Family-based study of AVPR1B association and interaction with stressful life events on depression and anxiety in suicide attempts","volume":"38","author":"Wasserman","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jpsychires.2020.05.017","article-title":"Efficacy and safety of TS-121, a novel vasopressin V(1B) receptor antagonist, as adjunctive treatment for patients with major depressive disorder: A randomized, double-blind, placebo-controlled study","volume":"128","author":"Kamiya","year":"2020","journal-title":"J. Psychiatr. Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"e00628","DOI":"10.1002\/brb3.628","article-title":"Hypothalamic-pituitary-adrenal axis and depression symptom effects of an arginine vasopressin type 1B receptor antagonist in a one-week randomized Phase 1b trial","volume":"7","author":"Katz","year":"2017","journal-title":"Brain Behav."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3389\/fpsyt.2020.00453","article-title":"Vasopressin Surrogate Marker Copeptin as a Potential Novel Endocrine Biomarker for Antidepressant Treatment Response in Major Depression: A Pilot Study","volume":"11","author":"Agorastos","year":"2020","journal-title":"Front. Psychiatry"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"6370","DOI":"10.1073\/pnas.092012099","article-title":"Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders","volume":"99","author":"Griebel","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.pnpbp.2006.12.008","article-title":"An arginine vasopressin V1b antagonist, SSR149415 elicits antidepressant-like effects in an olfactory bulbectomy model","volume":"31","author":"Iijima","year":"2007","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1111\/bph.12699","article-title":"Antidepressant and anxiolytic profiles of newly synthesized arginine vasopressin V1B receptor antagonists: TASP0233278 and TASP0390325","volume":"171","author":"Iijima","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.physbeh.2014.06.011","article-title":"The effect of blockade of the central V1 vasopressin receptors on anhedonia in chronically stressed infarcted and non-infarcted rats","volume":"135","author":"Puchalska","year":"2014","journal-title":"Physiol. Behav."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"R672","DOI":"10.1152\/ajpregu.00543.2009","article-title":"Brain vasopressin V(1) receptors contribute to enhanced cardiovascular responses to acute stress in chronically stressed rats and rats with myocardial infarction","volume":"298","author":"Dobruch","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"e12535","DOI":"10.1111\/gbb.12535","article-title":"Oxytocin and vasopressin in the rodent hippocampus","volume":"18","author":"Cilz","year":"2019","journal-title":"Genes Brain Behav."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3109\/10253890802687688","article-title":"Central oxytocin modulation of acute stress-induced cardiovascular responses after myocardial infarction in the rat","volume":"12","author":"Wsol","year":"2009","journal-title":"Stress"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3109\/10253890.2013.872620","article-title":"Oxytocin differently regulates pressor responses to stress in WKY and SHR rats: The role of central oxytocin and V1a receptors","volume":"17","author":"Wsol","year":"2014","journal-title":"Stress"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"R160","DOI":"10.1152\/ajpregu.00050.2019","article-title":"Impaired hypotensive effects of centrally acting oxytocin in SHR and WKY rats exposed to chronic mild stress","volume":"318","author":"Wsol","year":"2020","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00210-008-0336-1","article-title":"SSR149415, a non-peptide vasopressin V1b receptor antagonist, has long-lasting antidepressant effects in the olfactory bulbectomy-induced hyperactivity depression model","volume":"379","author":"Breuer","year":"2009","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/1025389032000114524","article-title":"Functional and pharmacological characterization of the first specific agonist and antagonist for the V1b receptor in mammals","volume":"6","author":"Derick","year":"2003","journal-title":"Stress"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/archpsyc.1986.01800040092013","article-title":"Cerebrospinal fluid vasopressin, oxytocin, somatostatin, and beta-endorphin in Alzheimer\u2019s disease","volume":"43","author":"Raskind","year":"1986","journal-title":"Arch. Gen Psychiatry"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/ana.410200603","article-title":"Vasopressin in Alzheimer\u2019s disease: A study of postmortem brain concentrations","volume":"20","author":"Mazurek","year":"1986","journal-title":"Ann. Neurol."},{"key":"ref_150","first-page":"1193","article-title":"Changes in vasopressin neurons and fibers in aging and Alzheimer\u2019s disease: Reversibility in the rat","volume":"317","author":"Goudsmit","year":"1989","journal-title":"Prog. Clin. Biol. Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/j.1365-2826.2009.01890.x","article-title":"Hypothalamic vasopressin and oxytocin mRNA expression in relation to depressive state in Alzheimer\u2019s disease: A difference with major depressive disorder","volume":"21","author":"Meynen","year":"2009","journal-title":"J. Neuroendocrinol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0006-8993(94)91082-0","article-title":"Stable vasopressin innervation in the degenerating human locus coeruleus in Alzheimer\u2019s disease","volume":"649","author":"Ravid","year":"1994","journal-title":"Brain Res."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s12264-019-00434-0","article-title":"AVP(4-8) Improves Cognitive Behaviors and Hippocampal Synaptic Plasticity in the APP\/PS1 Mouse Model of Alzheimer\u2019s Disease","volume":"36","author":"Zhang","year":"2020","journal-title":"Neurosci. Bull."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/mp.2015.189","article-title":"Targeted activation of the hippocampal CA2 area strongly enhances social memory","volume":"21","author":"Smith","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1600-0447.1991.tb05539.x","article-title":"Reduced concentrations of galanin, arginine vasopressin, neuropeptide Y and peptide YY in the temporal cortex but not in the hypothalamus of brains from schizophrenics","volume":"83","author":"Frederiksen","year":"1991","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"e01355","DOI":"10.1002\/brb3.1355","article-title":"Expression of vasopressin mRNA in the hypothalamus of individuals with a diagnosis of schizophrenia","volume":"9","author":"Busch","year":"2019","journal-title":"Brain Behav."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.2147\/NDT.S169619","article-title":"Atrial natriuretic peptide and posterior pituitary neurohormone changes in patients with acute schizophrenia","volume":"14","author":"Guzel","year":"2018","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3389\/fpsyt.2019.00217","article-title":"Decreased Serum Oxytocin and Increased Homocysteine in First-Episode Schizophrenia Patients","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Psychiatry"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.schres.2013.01.019","article-title":"Peripheral vasopressin but not oxytocin relates to severity of acute psychosis in women with acutely-ill untreated first-episode psychosis","volume":"146","author":"Rubin","year":"2013","journal-title":"Schizophr. Res."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.brainresrev.2009.06.004","article-title":"The mechanism of life-threatening water imbalance in schizophrenia and its relationship to the underlying psychiatric illness","volume":"61","author":"Goldman","year":"2009","journal-title":"Brain Res. Rev."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1001\/archpsyc.1997.01830170069010","article-title":"Psychotic exacerbations and enhanced vasopressin secretion in schizophrenic patients with hyponatremia and polydipsia","volume":"54","author":"Goldman","year":"1997","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1600-0447.1993.tb03426.x","article-title":"Atrial natriuretic peptide and arginine vasopressin secretion in schizophrenic patients","volume":"88","author":"Ohsawa","year":"1993","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.euroneuro.2014.02.001","article-title":"Intranasal desmopressin as an adjunct to risperidone for negative symptoms of schizophrenia: A randomized, double-blind, placebo-controlled, clinical trial","volume":"24","author":"Hosseini","year":"2014","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1017\/S1461145711001374","article-title":"Oxytocin and vasopressin genes are significantly associated with schizophrenia in a large Arab-Israeli pedigree","volume":"15","author":"Teltsh","year":"2012","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1177\/0269881108098787","article-title":"Further neurochemical and behavioural investigation of Brattleboro rats as a putative model of schizophrenia","volume":"24","author":"Cilia","year":"2010","journal-title":"J. Psychopharmacol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bbr.2015.12.007","article-title":"Possible contribution of epigenetic changes in the development of schizophrenia-like behavior in vasopressin-deficient Brattleboro rats","volume":"300","author":"Demeter","year":"2016","journal-title":"Behav. Brain Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bbr.2006.12.009","article-title":"Impaired social interaction and reduced anxiety-related behavior in vasopressin V1a receptor knockout mice","volume":"178","author":"Egashira","year":"2007","journal-title":"Behav. Brain Res."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"108040","DOI":"10.1016\/j.neuropharm.2020.108040","article-title":"Social dysfunction in the neurodevelopmental model of schizophrenia in male and female rats: Behavioural and biochemical studies","volume":"170","author":"Potasiewicz","year":"2020","journal-title":"Neuropharmacology"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/ana.25314","article-title":"Cerebrospinal fluid vasopressin and symptom severity in children with autism","volume":"84","author":"Oztan","year":"2018","journal-title":"Ann. Neurol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"10609","DOI":"10.1073\/pnas.1919050117","article-title":"Neonatal CSF vasopressin concentration predicts later medical record diagnoses of autism spectrum disorder","volume":"117","author":"Oztan","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.psyneuen.2017.12.022","article-title":"Biomarker discovery for disease status and symptom severity in children with autism","volume":"89","author":"Oztan","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3389\/fnins.2016.00516","article-title":"ASD and Genetic Associations with Receptors for Oxytocin and Vasopressin-AVPR1A, AVPR1B, and OXTR","volume":"10","author":"Francis","year":"2016","journal-title":"Front. Neurosci."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fnmol.2018.00027","article-title":"A Review of Oxytocin and Arginine-Vasopressin Receptors and Their Modulation of Autism Spectrum Disorder","volume":"11","author":"Cataldo","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.neulet.2010.05.050","article-title":"Association study between single nucleotide polymorphisms in promoter region of AVPR1A and Korean autism spectrum disorders","volume":"479","author":"Yang","year":"2010","journal-title":"Neurosci. Lett."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.psychres.2009.11.007","article-title":"Family-based association study of microsatellites in the 5\u2032 flanking region of AVPR1A with autism spectrum disorder in the Korean population","volume":"178","author":"Yang","year":"2010","journal-title":"Psychiatry Res."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"8119","DOI":"10.1073\/pnas.1705521114","article-title":"Intranasal oxytocin treatment for social deficits and biomarkers of response in children with autism","volume":"114","author":"Parker","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"eaau7356","DOI":"10.1126\/scitranslmed.aau7356","article-title":"A randomized placebo-controlled pilot trial shows that intranasal vasopressin improves social deficits in children with autism","volume":"11","author":"Parker","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/ddr.21343","article-title":"Effects of Intranasal Oxytocin on Long-Term Memory in Healthy Humans: A Systematic Review","volume":"77","author":"Brambilla","year":"2016","journal-title":"Drug Dev. Res."},{"key":"ref_179","first-page":"48","article-title":"Neuropeptides vasopressin (AVP), oxytocin (OXT) and corticotropin-releasing hormone (CRH) in the human hypothalamus: Activity changes in aging, Alzheimer\u2019s disease and depression","volume":"9","author":"Lucassen","year":"1997","journal-title":"Aging"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1212\/WNL.37.6.1001","article-title":"Oxytocin in Alzheimer\u2019s disease: Postmortem brain levels","volume":"37","author":"Mazurek","year":"1987","journal-title":"Neurology"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/0006-8993(95)01141-2","article-title":"Differential vasopressin and oxytocin innervation of the human parabrachial nucleus: No changes in Alzheimer\u2019s disease","volume":"711","author":"Ravid","year":"1996","journal-title":"Brain Res."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/0197-4580(91)90081-T","article-title":"Oxytocin cell number in the human paraventricular nucleus remains constant with aging and in Alzheimer\u2019s disease","volume":"12","author":"Wierda","year":"1991","journal-title":"Neurobiol. Aging"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1080\/00207454.2020.1831490","article-title":"Comparative study of the volume of the temporal lobe sections and neuropeptide effect in Alzheimer\u2019s patients and healthy persons","volume":"131","author":"Petekkaya","year":"2021","journal-title":"Int. J. Neurosci."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s003930070045","article-title":"Plasma oxytocin levels in female fibromyalgia syndrome patients","volume":"59","author":"Anderberg","year":"2000","journal-title":"Z. Rheumatol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1038\/npp.2017.76","article-title":"Direct Involvement of Androgen Receptor in Oxytocin Gene Expression: Possible Relevance for Mood Disorders","volume":"42","author":"Dai","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/sj.mp.4001911","article-title":"Hypothalamic oxytocin mRNA expression and melancholic depression","volume":"12","author":"Meynen","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.psychres.2008.06.034","article-title":"Serum oxytocin levels in patients with depression and the effects of gender and antidepressant treatment","volume":"169","author":"Ozsoy","year":"2009","journal-title":"Psychiatry Res."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.psyneuen.2007.01.009","article-title":"Plasma oxytocin levels and anxiety in patients with major depression","volume":"32","author":"Scantamburlo","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"487","DOI":"10.9758\/cpn.2019.17.4.487","article-title":"The Interaction of Oxytocin and Social Support, Loneliness, and Cortisol Level in Major Depression","volume":"17","author":"Tsai","year":"2019","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.psyneuen.2011.03.007","article-title":"The influence of depressive symptomatology and perceived stress on plasma and salivary oxytocin before, during and after a support enhancement intervention","volume":"36","author":"Birmingham","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.psychres.2009.09.017","article-title":"Preliminary evidence that plasma oxytocin levels are elevated in major depression","volume":"178","author":"Parker","year":"2010","journal-title":"Psychiatry Res."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"105085","DOI":"10.1016\/j.psyneuen.2020.105085","article-title":"The role of oxytocin signaling in depression and suicidality in returning war veterans","volume":"126","author":"Warrener","year":"2021","journal-title":"Psychoneuroendocrinology"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.psyneuen.2017.10.018","article-title":"Plasma cortisol and oxytocin levels predict help-seeking intentions for depressive symptoms","volume":"87","author":"Thomas","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jad.2017.10.037","article-title":"Oxytocin plasma levels predict the outcome of psychotherapy: A pilot study in chronic depression","volume":"227","author":"Jobst","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.psychres.2008.04.009","article-title":"Mutation analysis of oxytocin gene in individuals with adult separation anxiety","volume":"168","author":"Costa","year":"2009","journal-title":"Psychiatry Res."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.psyneuen.2009.05.006","article-title":"Oxytocin receptor polymorphisms and adult attachment style in patients with depression","volume":"34","author":"Costa","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.psyneuen.2010.07.003","article-title":"Oxytocin receptor gene polymorphism (rs2254298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls","volume":"36","author":"Thompson","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.jad.2017.03.056","article-title":"Oxytocin receptor and G-protein polymorphisms in patients with depression and separation anxiety","volume":"218","author":"Costa","year":"2017","journal-title":"J. Affect. Disord."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"7685","DOI":"10.1038\/s41598-019-44175-6","article-title":"Interaction effect of oxytocin receptor (OXTR) rs53576 genotype and maternal postpartum depression on child behavioural problems","volume":"9","author":"Choi","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jad.2018.05.022","article-title":"Attempted suicide and oxytocin-related gene polymorphisms","volume":"238","author":"Parris","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0306-4522(99)00433-9","article-title":"Brain oxytocin: Differential inhibition of neuroendocrine stress responses and anxiety-related behaviour in virgin, pregnant and lactating rats","volume":"95","author":"Neumann","year":"2000","journal-title":"Neuroscience"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1089\/jwh.2012.3768","article-title":"Association between maternal mood and oxytocin response to breastfeeding","volume":"22","author":"Stuebe","year":"2013","journal-title":"J. Women\u2019s Health"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1017\/neu.2014.20","article-title":"Oxytocin and vasopressin levels are decreased in the plasma of male schizophrenia patients","volume":"26","author":"Jobst","year":"2014","journal-title":"Acta Neuropsychiatr."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.schres.2018.09.013","article-title":"Effects of oxytocin on empathy, introspective accuracy, and social symptoms in schizophrenia: A 12-week twice-daily randomized controlled trial","volume":"204","author":"Halverson","year":"2019","journal-title":"Schizophr. Res."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.psyneuen.2014.04.024","article-title":"Oxytocin administration enhances controlled social cognition in patients with schizophrenia","volume":"47","author":"Woolley","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.schres.2016.02.011","article-title":"Do we need oxytocin to treat schizophrenia? A randomized clinical trial","volume":"172","author":"Dagani","year":"2016","journal-title":"Schizophr. Res."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.schres.2017.01.008","article-title":"A 12-week randomized controlled trial of twice-daily intranasal oxytocin for social cognitive deficits in people with schizophrenia","volume":"185","author":"Jarskog","year":"2017","journal-title":"Schizophr. Res."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00406-015-0634-9","article-title":"Efficacy and safety of oxytocin augmentation therapy for schizophrenia: An updated systematic review and meta-analysis of randomized, placebo-controlled trials","volume":"266","author":"Oya","year":"2016","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.psyneuen.2016.10.013","article-title":"Effects of intranasal oxytocin on symptoms of schizophrenia: A multivariate Bayesian meta-analysis","volume":"75","author":"Williams","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/ana.20722","article-title":"Search for autism loci by combined analysis of Autism Genetic Resource Exchange and Finnish families","volume":"59","author":"Cantor","year":"2006","journal-title":"Ann. Neurol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.biopsych.2005.03.013","article-title":"Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population","volume":"58","author":"Wu","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.neulet.2007.02.001","article-title":"Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism","volume":"417","author":"Jacob","year":"2007","journal-title":"Neurosci. Lett."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/jhg.2009.140","article-title":"Association of the oxytocin receptor (OXTR) gene polymorphisms with autism spectrum disorder (ASD) in the Japanese population","volume":"55","author":"Liu","year":"2010","journal-title":"J. Hum. Genet."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1073\/pnas.1302985111","article-title":"Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills","volume":"111","author":"Skuse","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11689-010-9071-2","article-title":"Association of oxytocin receptor (OXTR) gene variants with multiple phenotype domains of autism spectrum disorder","volume":"3","author":"Campbell","year":"2011","journal-title":"J. Neurodev. Disord."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/mp.2014.77","article-title":"The oxytocin receptor gene (OXTR) is associated with autism spectrum disorder: A meta-analysis","volume":"20","author":"LoParo","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1002\/aur.1597","article-title":"Meta-analysis and association of two common polymorphisms of the human oxytocin receptor gene in autism spectrum disorder","volume":"9","author":"Kranz","year":"2016","journal-title":"Autism Res."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0006-3223(01)01139-8","article-title":"Oxytocin and autistic disorder: Alterations in peptide forms","volume":"50","author":"Green","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4306\/pi.2016.13.2.174","article-title":"Plasma Oxytocin in Children with Autism and Its Correlations with Behavioral Parameters in Children and Parents","volume":"13","author":"Husarova","year":"2016","journal-title":"Psychiatry Investig."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1177\/13623613211034375","article-title":"Oxytocin levels tend to be lower in autistic children: A meta-analysis of 31 studies","volume":"25","author":"John","year":"2021","journal-title":"Autism"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0006-3223(97)00439-3","article-title":"Plasma oxytocin levels in autistic children","volume":"43","author":"Modahl","year":"1998","journal-title":"Biol. Psychiatry"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/sj.npp.1300021","article-title":"Oxytocin infusion reduces repetitive behaviors in adults with autistic and Asperger\u2019s disorders","volume":"28","author":"Hollander","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1038\/s41380-018-0097-2","article-title":"Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder: A randomized clinical trial","volume":"25","author":"Yamasue","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/s41386-018-0258-7","article-title":"Neural modulation of social reinforcement learning by intranasal oxytocin in male adults with high-functioning autism spectrum disorder: A randomized trial","volume":"44","author":"Kruppa","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13229-020-0313-1","article-title":"Behavioral effects of multiple-dose oxytocin treatment in autism: A randomized, placebo-controlled trial with long-term follow-up","volume":"11","author":"Bernaerts","year":"2020","journal-title":"Mol. Autism"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s10803-013-1899-3","article-title":"Nasal oxytocin for social deficits in childhood autism: A randomized controlled trial","volume":"44","author":"Dadds","year":"2014","journal-title":"J. Autism Dev. Disord."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1007\/s10803-021-05237-9","article-title":"Decades of Progress in the Psychopharmacology of Autism Spectrum Disorder","volume":"51","author":"Henneberry","year":"2021","journal-title":"J. Autism Dev. Disord."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/pcn.12627","article-title":"Systematic review and meta-analysis of reported adverse events of long-term intranasal oxytocin treatment for autism spectrum disorder","volume":"72","author":"Cai","year":"2018","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1055\/s-0043-112345","article-title":"Validation of Brain Angiotensin System Blockade as a Novel Drug Target in Pharmacological Treatment of Neuropsychiatric Disorders","volume":"50","author":"Wincewicz","year":"2017","journal-title":"Pharmacopsychiatry"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s11357-020-00231-y","article-title":"Brain angiotensin II and angiotensin IV receptors as potential Alzheimer\u2019s disease therapeutic targets","volume":"42","author":"Royea","year":"2020","journal-title":"Geroscience"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S1357-2725(02)00263-7","article-title":"Angiotensin receptors: Form and function and distribution","volume":"35","author":"Thomas","year":"2003","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"S130","DOI":"10.1177\/14703203010020012301","article-title":"Candesartan decreases the sympatho-adrenal and hormonal response to isolation stress","volume":"2","author":"Armando","year":"2001","journal-title":"J. Renin-Angiotensin-Aldosterone Syst."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.1210\/endo.142.9.8366","article-title":"Peripheral administration of an angiotensin II AT(1) receptor antagonist decreases the hypothalamic-pituitary-adrenal response to isolation stress","volume":"142","author":"Armando","year":"2001","journal-title":"Endocrinology"},{"key":"ref_234","first-page":"262","article-title":"Involvement of Type 1 Angiontensin II Receptor (AT1) in Cardiovascular Changes Induced by Chronic Emotional Stress: Comparison between Homotypic and Heterotypic Stressors","volume":"7","author":"Vieira","year":"2016","journal-title":"Front. Pharmacol."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.neuroscience.2004.12.046","article-title":"A new role for the renin-angiotensin system in the rat periaqueductal gray matter: Angiotensin receptor-mediated modulation of nociception","volume":"132","author":"Martins","year":"2005","journal-title":"Neuroscience"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0196-9781(99)00040-6","article-title":"Brain renin angiotensin system (RAS) in stress-induced analgesia and impaired retention","volume":"20","author":"Raghavendra","year":"1999","journal-title":"Peptides"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0925-4927(00)00067-6","article-title":"Volumetric asymmetries in late-onset mood disorders: An attenuation of frontal asymmetry with depression severity","volume":"100","author":"Kumar","year":"2000","journal-title":"Psychiatry Res."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1007\/s11920-012-0322-7","article-title":"Where in the brain is depression?","volume":"14","author":"Pandya","year":"2012","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/386824a0","article-title":"Subgenual prefrontal cortex abnormalities in mood disorders","volume":"386","author":"Drevets","year":"1997","journal-title":"Nature"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1176\/ajp.156.5.675","article-title":"Reciprocal limbic-cortical function and negative mood: Converging PET findings in depression and normal sadness","volume":"156","author":"Mayberg","year":"1999","journal-title":"Am. J. Psychiatry"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jchemneu.2016.01.010","article-title":"Midcingulate cortex: Structure, connections, homologies, functions and diseases","volume":"74","author":"Vogt","year":"2016","journal-title":"J. Chem. Neuroanat."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1001\/archpsyc.1993.01820130009002","article-title":"Quantitative cerebral anatomy in depression. A controlled magnetic resonance imaging study","volume":"50","author":"Coffey","year":"1993","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/15622970109027497","article-title":"Structural neuroimaging studies in late-life depression: A review","volume":"2","author":"Schweitzer","year":"2001","journal-title":"World J. Biol. Psychiatry"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jad.2011.04.004","article-title":"The insular cortex and the neuroanatomy of major depression","volume":"133","author":"Sprengelmeyer","year":"2011","journal-title":"J. Affect. Disord."},{"key":"ref_245","first-page":"145","article-title":"Implications of the angiotensin converting enzyme gene insertion\/deletion polymorphism in health and disease: A snapshot review","volume":"1","author":"Gard","year":"2010","journal-title":"Int. J. Mol. Epidemiol. Genet."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1176\/appi.ajp.2014.13111543","article-title":"Association of gene variants of the renin-angiotensin system with accelerated hippocampal volume loss and cognitive decline in old age","volume":"171","author":"Zannas","year":"2014","journal-title":"Am. J. Psychiatry"},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/1570159X13666150716165726","article-title":"Alzheimer\u2019s disease: Targeting the Cholinergic System","volume":"14","author":"Guimaraes","year":"2016","journal-title":"Curr. Neuropharmacol."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.cell.2012.02.040","article-title":"Alzheimer mechanisms and therapeutic strategies","volume":"148","author":"Huang","year":"2012","journal-title":"Cell"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1172\/JCI31547","article-title":"Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease","volume":"117","author":"Wang","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"16917","DOI":"10.3390\/ijms140816917","article-title":"ACE inhibition with captopril retards the development of signs of neurodegeneration in an animal model of Alzheimer\u2019s disease","volume":"14","author":"AbdAlla","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1474-4422(10)70250-7","article-title":"Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: Analysis of data from the ONTARGET and TRANSCEND studies","volume":"10","author":"Anderson","year":"2011","journal-title":"Lancet Neurol."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1111\/j.1742-1241.2011.02810.x","article-title":"The association of antihypertensive medication use with risk of cognitive decline and dementia: A meta-analysis of longitudinal studies","volume":"65","author":"Hui","year":"2011","journal-title":"Int. J. Clin. Pract."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1212\/01.WNL.0000140705.23869.E9","article-title":"Effects of brain-penetrating ACE inhibitors on Alzheimer disease progression","volume":"63","author":"Ohrui","year":"2004","journal-title":"Neurology"},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"723","DOI":"10.2165\/00002512-200219100-00001","article-title":"Does the angiotensin II receptor antagonist losartan improve cognitive function?","volume":"19","author":"Tedesco","year":"2002","journal-title":"Drugs Aging"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jocn.2016.02.036","article-title":"The association of renin-angiotensin system blockade use with the risks of cognitive impairment of aging and Alzheimer\u2019s disease: A meta-analysis","volume":"33","author":"Zhuang","year":"2016","journal-title":"J. Clin. Neurosci."},{"key":"ref_256","doi-asserted-by":"crossref","unstructured":"Barthold, D., Joyce, G., Diaz Brinton, R., Wharton, W., Kehoe, P.G., and Zissimopoulos, J. (2020). Association of combination statin and antihypertensive therapy with reduced Alzheimer\u2019s disease and related dementia risk. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0229541"},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1002\/mds.23348","article-title":"Exploring the electrocardiogram as a potential tool to screen for premotor Parkinson\u2019s disease","volume":"25","author":"Valappil","year":"2010","journal-title":"Mov. Disord."},{"key":"ref_258","first-page":"860923","article-title":"Importance of the brain Angiotensin system in Parkinson\u2019s disease","volume":"2012","author":"Wright","year":"2012","journal-title":"Parkinson\u2019s Dis."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1177\/1470320313494432","article-title":"The angiotensin-converting enzyme (ACE) I\/D polymorphism in Parkinson\u2019s disease","volume":"16","author":"Su","year":"2015","journal-title":"J. Renin-Angiotensin-Aldosterone Syst."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"e001286","DOI":"10.1136\/openhrt-2020-001286","article-title":"Higher risk of major adverse cardiac events after acute myocardial infarction in patients with schizophrenia","volume":"7","author":"Attar","year":"2020","journal-title":"Open Heart"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12991-020-00284-5","article-title":"Recording of cardiovascular risk factors by general practitioners in patients with schizophrenia","volume":"19","author":"Castillejos","year":"2020","journal-title":"Ann. Gen. Psychiatry"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.schres.2008.07.006","article-title":"Antipsychotic effects on estimated 10-year coronary heart disease risk in the CATIE schizophrenia study","volume":"105","author":"Daumit","year":"2008","journal-title":"Schizophr. Res."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s11126-016-9468-5","article-title":"Blood Pressure and Heart Rate Changes during Clozapine Treatment","volume":"88","author":"Norman","year":"2017","journal-title":"Psychiatr. Q."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s40263-019-00632-4","article-title":"The Possible Role of the Angiotensin System in the Pathophysiology of Schizophrenia: Implications for Pharmacotherapy","volume":"33","author":"Oh","year":"2019","journal-title":"CNS Drugs"},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1001\/jamapsychiatry.2018.2742","article-title":"Association of Secondary Preventive Cardiovascular Treatment after Myocardial Infarction with Mortality among Patients with Schizophrenia","volume":"75","author":"Kugathasan","year":"2018","journal-title":"JAMA Psychiatry"},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1177\/1470320313495909","article-title":"The insertion\/deletion polymorphism in the angiotensin-converting enzyme and susceptibility to schizophrenia or Parkinson\u2019s disease: A meta-analysis","volume":"16","author":"Song","year":"2015","journal-title":"J. Renin-Angiotensin-Aldosterone Syst."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1046\/j.1440-1614.2001.00847.x","article-title":"Treatment of psychogenic polydipsia: Comparison of risperidone and olanzapine, and the effects of an adjunctive angiotensin-II receptor blocking drug (irbesartan)","volume":"35","author":"Kruse","year":"2001","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"ref_268","doi-asserted-by":"crossref","unstructured":"Firouzabadi, N., Ghazanfari, N., Alavi Shoushtari, A., Erfani, N., Fathi, F., Bazrafkan, M., and Bahramali, E. (2016). Genetic Variants of Angiotensin-Converting Enzyme Are Linked to Autism: A Case-Control Study. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0153667"},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s10787-021-00806-x","article-title":"Neuropathophysiology of coronavirus disease 2019: Neuroinflammation and blood brain barrier disruption are critical pathophysiological processes that contribute to the clinical symptoms of SARS-CoV-2 infection","volume":"29","author":"Welcome","year":"2021","journal-title":"Inflammopharmacology"},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3389\/fphys.2020.00730","article-title":"Activation of Ang-(1-7)\/Mas Receptor Is a Possible Strategy to Treat Coronavirus (SARS-CoV-2) Infection","volume":"11","author":"Magalhaes","year":"2020","journal-title":"Front. Physiol."},{"key":"ref_271","doi-asserted-by":"crossref","unstructured":"Zamai, L. (2000). The Yin and Yang of ACE\/ACE2 pathways: The rationale for the use of renin-angiotensin system inhibitors in COVID-19 patients. Cells, 9.","DOI":"10.3390\/cells9071704"},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1126\/science.abb2762","article-title":"Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2","volume":"367","author":"Yan","year":"2020","journal-title":"Science"},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"R373","DOI":"10.1152\/ajpregu.00292.2006","article-title":"Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system","volume":"292","author":"Doobay","year":"2007","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"C420","DOI":"10.1152\/ajpcell.00409.2004","article-title":"Distinct roles for ANG II and ANG-(1-7) in the regulation of angiotensin-converting enzyme 2 in rat astrocytes","volume":"290","author":"Gallagher","year":"2006","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1161\/01.HYP.0000178157.70142.33","article-title":"Impaired heart rate baroreflex in older rats: Role of endogenous angiotensin-(1-7) at the nucleus tractus solitarii","volume":"46","author":"Sakima","year":"2005","journal-title":"Hypertension"},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"105131","DOI":"10.1016\/j.nbd.2020.105131","article-title":"The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood-brain barrier","volume":"146","author":"Buzhdygan","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13195-016-0217-7","article-title":"Angiotensin-converting enzyme 2 is reduced in Alzheimer\u2019s disease in association with increasing amyloid-\u03b2 and tau pathology","volume":"8","author":"Kehoe","year":"2016","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"573095","DOI":"10.3389\/fneur.2020.573095","article-title":"The Spatial and Cell-Type Distribution of SARS-CoV-2 Receptor ACE2 in the Human and Mouse Brains","volume":"11","author":"Chen","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.stemcr.2021.01.016","article-title":"SARS-CoV-2 targets glial cells in human cortical organoids","volume":"16","author":"McMahon","year":"2021","journal-title":"Stem Cell Rep."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"7264","DOI":"10.1128\/JVI.00737-08","article-title":"Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2","volume":"82","author":"Netland","year":"2008","journal-title":"J. Virol."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/path.1560","article-title":"Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: Implications for pathogenesis and virus transmission pathways","volume":"203","author":"Ding","year":"2004","journal-title":"J. Pathol."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1086\/444461","article-title":"Detection of severe acute respiratory syndrome coronavirus in the brain: Potential role of the chemokine mig in pathogenesis","volume":"41","author":"Xu","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"e20202135","DOI":"10.1084\/jem.20202135","article-title":"Neuroinvasion of SARS-CoV-2 in human and mouse brain","volume":"218","author":"Song","year":"2021","journal-title":"J. Exp. Med."},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1093\/cvr\/cvaa250","article-title":"Autonomic innervation of the carotid body as a determinant of its sensitivity: Implications for cardiovascular physiology and pathology","volume":"117","author":"Brognara","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"102810","DOI":"10.1016\/j.autneu.2021.102810","article-title":"Relevance of carotid bodies in COVID-19: A hypothetical viewpoint","volume":"233","author":"Machado","year":"2021","journal-title":"Auton Neurosci."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"L620","DOI":"10.1152\/ajplung.00309.2020","article-title":"The potential role of the carotid body in COVID-19","volume":"319","author":"Porzionato","year":"2020","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"zqaa032","DOI":"10.1093\/function\/zqaa032","article-title":"Is Carotid Body Infection Responsible for Silent Hypoxemia in COVID-19 Patients?","volume":"2","author":"Villadiego","year":"2020","journal-title":"Function"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s00134-021-06351-z","article-title":"SARS-CoV-2 in carotid body","volume":"47","author":"Lambermont","year":"2021","journal-title":"Intensive Care Med."},{"key":"ref_289","doi-asserted-by":"crossref","unstructured":"Szczepanska-Sadowska, E., Wsol, A., Cudnoch-Jedrzejewska, A., and \u017bera, T. (2021). Complementary role of oxytocin and vasopressin in cardiovascular regulation. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111465"},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"306","DOI":"10.2174\/1389200218666170119145900","article-title":"Vasopressin and related peptides; potential value in diagnosis, prognosis and treatment of clinical disorders","volume":"18","author":"Zera","year":"2017","journal-title":"Curr. Drug Metab."},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1152\/physrev.2001.81.2.629","article-title":"The oxytocin receptor system: Structure, function, and regulation","volume":"81","author":"Gimpl","year":"2001","journal-title":"Physiol. Rev."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0361-9230(02)00943-7","article-title":"Differential expression of vasopressin V1a and V1b receptors mRNA in the brain of renin transgenic TGR (mRen2) 27 and Sprague\u2013Dawley rats","volume":"59","author":"Kumosa","year":"2003","journal-title":"Brain Res. Bull."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/(SICI)1096-9861(19990823)411:2<201::AID-CNE3>3.0.CO;2-3","article-title":"Spinal cord-projecting vasopressinergic neurons in the rat paraventricular hypothalamus","volume":"411","author":"Hallbeck","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/(SICI)1096-9861(19990823)411:2<181::AID-CNE2>3.0.CO;2-1","article-title":"Distribution of preprovasopressin mRNA in the rat central nervous system","volume":"411","author":"Hallbeck","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/0306-4522(88)90180-7","article-title":"Localization of vasopressin binding sites in rat brain by in vitro autoradiography using a radioiodinated V1 receptor antagonist","volume":"27","author":"Phillips","year":"1988","journal-title":"Neuroscience"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1046\/j.1365-2826.1999.00332.x","article-title":"Localization of vasopressin (V1a) receptor binding and mRNA in the rhesus monkey brain","volume":"11","author":"Young","year":"1999","journal-title":"J. Neuroendocrinol."},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"101975","DOI":"10.1016\/j.npep.2019.101975","article-title":"The influence of post-infarct heart failure and high fat diet on the expression of apelin APJ and vasopressin V1a and V1b receptors","volume":"78","author":"Czarzasta","year":"2019","journal-title":"Neuropeptides"},{"key":"ref_298","first-page":"R548","article-title":"Central losartan blocks natriuretic, vasopressin, and pressor responses to central hypertonic NaCl in sheep","volume":"275","author":"Mathai","year":"1998","journal-title":"Am. J. Physiol."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/ki.2009.103","article-title":"Interactions between angiotensin II and arginine vasopressin in water homeostasis","volume":"76","author":"Schrier","year":"2009","journal-title":"Kidney Int."},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1177\/1073858417708284","article-title":"Oxytocin and Vasopressin: Powerful Regulators of Social Behavior","volume":"23","author":"Caldwell","year":"2017","journal-title":"Neuroscientist"},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"567","DOI":"10.3389\/fnins.2017.00567","article-title":"Social Context, Stress, Neuropsychiatric Disorders, and the Vasopressin 1b Receptor","volume":"11","author":"Caldwell","year":"2017","journal-title":"Front. Neurosci."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0924270800034931","article-title":"Neuropeptides as psychotropic drugs","volume":"4","year":"1992","journal-title":"Acta Neuropsychiatr."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1080\/10298420290031432","article-title":"Neuropeptides involved in the pathophysiology of schizophrenia and major depression","volume":"4","author":"Sigling","year":"2002","journal-title":"Neurotox. Res."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1176\/appi.ajp.2020.19080848","article-title":"Hormonal Treatments for Major Depressive Disorder: State of the Art","volume":"177","author":"Dwyer","year":"2020","journal-title":"Am. J. Psychiatry"},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ejphar.2007.11.063","article-title":"The vasopressin system-from antidiuresis to psychopathology","volume":"583","author":"Frank","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"341","DOI":"10.2174\/1871530318666180220104900","article-title":"The Role of Neurohypophyseal Hormones Vasopressin and Oxytocin in Neuropsychiatric Disorders","volume":"18","author":"Iovino","year":"2018","journal-title":"Endocr. Metab. Immune Disord. Drug Targets Actions"},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1177\/0891988720915526","article-title":"Serum Oxytocin Levels and Logical Memory in Older People in Rural Japan","volume":"34","author":"Kunitake","year":"2021","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/sj.npp.1300002","article-title":"Anxious-retarded depression: Relation with plasma vasopressin and cortisol","volume":"28","author":"Zwinderman","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1192\/bjp.147.6.696","article-title":"Cerebrospinal fluid vasopressin-changes in depression","volume":"147","author":"Gjerris","year":"1985","journal-title":"Br. J. Psychiatry"},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1093\/schbul\/sbu027","article-title":"Reduced levels of vasopressin and reduced behavioral modulation of oxytocin in psychotic disorders","volume":"40","author":"Rubin","year":"2014","journal-title":"Schizophr. Bull."},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.ejphar.2007.11.065","article-title":"Involvement of vasopressin in affective disorders","volume":"583","author":"Surget","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0893-133X(97)00054-7","article-title":"Plasma levels of arginine vasopressin elevated in patients with major depression","volume":"17","author":"Goekoop","year":"1997","journal-title":"Neuropsychopharmacology"},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.psychres.2016.04.117","article-title":"Peripheral oxytocin and vasopressin: Biomarkers of psychiatric disorders? A comprehensive systematic review and preliminary meta-analysis","volume":"241","author":"Rutigliano","year":"2016","journal-title":"Psychiatry Res."},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/YCT.0000000000000388","article-title":"Serum Oxytocin Concentration in Patients Receiving Electroconvulsive Therapy: An Exploratory Study and Review of Literature","volume":"33","author":"Barhale","year":"2017","journal-title":"J. ECT"},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/0278-5846(88)90072-3","article-title":"Oxytocin: Neurobiologic considerations and their implications for affective illness","volume":"12","author":"Demitrack","year":"1988","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.schres.2012.06.016","article-title":"Negative correlation between cerebrospinal fluid oxytocin levels and negative symptoms of male patients with schizophrenia","volume":"139","author":"Sasayama","year":"2012","journal-title":"Schizophr. Res."},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0006-3223(95)00229-A","article-title":"Cerebrospinal fluid corticotropin-releasing hormone, vasopressin, and oxytocin concentrations in treated patients with major depression and controls","volume":"38","author":"Pitts","year":"1995","journal-title":"Biol. Psychiatry"},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.psyneuen.2018.05.039","article-title":"Oxytocin receptor mRNA expression in dorsolateral prefrontal cortex in major psychiatric disorders: A human post-mortem study","volume":"96","author":"Lee","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.yfrne.2004.05.001","article-title":"Vasopressin and oxytocin release within the brain: A dynamic concept of multiple and variable modes of neuropeptide communication","volume":"25","author":"Landgraf","year":"2004","journal-title":"Front. Neuroendocrinol."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"4798","DOI":"10.1210\/jcem.86.10.7919","article-title":"Effects of suckling on hypothalamic-pituitary-adrenal axis responses to psychosocial stress in postpartum lactating women","volume":"86","author":"Heinrichs","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1038\/npp.2011.74","article-title":"Plasma oxytocin concentration during pregnancy is associated with development of postpartum depression","volume":"36","author":"Skrundz","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9758\/cpn.2019.17.1.1","article-title":"The Role of Intranasal Oxytocin in Anxiety and Depressive Disorders: A Systematic Review of Randomized Controlled Trials","volume":"17","author":"Damiani","year":"2019","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.psyneuen.2018.11.011","article-title":"The endogenous oxytocin system in depressive disorders: A systematic review and meta-analysis","volume":"101","author":"Engel","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.brainres.2013.11.009","article-title":"Oxytocin and postpartum depression: Delivering on what\u2019s known and what\u2019s not","volume":"1580","author":"Kim","year":"2014","journal-title":"Brain Res."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00737-016-0643-3","article-title":"Oxytocin and depression in the perinatal period-a systematic review","volume":"19","author":"Moura","year":"2016","journal-title":"Arch. Women\u2019s Ment. Health"},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.eurpsy.2014.08.007","article-title":"Additional intranasal oxytocin to escitalopram improves depressive symptoms in resistant depression: An open trial","volume":"30","author":"Scantamburlo","year":"2015","journal-title":"Eur. Psychiatry"},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3389\/fpsyt.2010.00134","article-title":"Inverse effects of oxytocin on attributing mental activity to others in depressed and healthy subjects: A double-blind placebo controlled FMRI study","volume":"1","author":"Pincus","year":"2010","journal-title":"Front. Psychiatry"},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0165-1781(93)90035-F","article-title":"Effects of intranasal vasopressin and oxytocin on physiologic responding during personal combat imagery in Vietnam veterans with posttraumatic stress disorder","volume":"48","author":"Pitman","year":"1993","journal-title":"Psychiatry Res."},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s13148-019-0755-5","article-title":"Alzheimer\u2019s disease-associated (hydroxy)methylomic changes in the brain and blood","volume":"11","author":"Lardenoije","year":"2019","journal-title":"Clin. Epigenetics"},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.nurt.2010.05.006","article-title":"Autism and oxytocin: New developments in translational approaches to therapeutics","volume":"7","author":"Green","year":"2010","journal-title":"Neurotherapeutics"},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s12264-016-0046-5","article-title":"Plasma oxytocin and arginine-vasopressin levels in childre with autism spectrum disorders in China: Association with symptoms","volume":"32","author":"Zhang","year":"2016","journal-title":"Neurosci. Bull."},{"key":"ref_332","doi-asserted-by":"crossref","unstructured":"Hendaus, M., Jomha, F.A., and Alhammadi, A.H. (2019). Vasopressin in the Amelioration of Social Functioning in Autism Spectrum Disorder. J. Clin. Med., 8.","DOI":"10.3390\/jcm8071061"},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/mp.2015.162","article-title":"The effect of oxytocin nasal spray on social interaction deficits observed in young children with autism: A randomized clinical crossover trial","volume":"21","author":"Yatawara","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fendo.2015.00090","article-title":"A Role for Oxytocin in the Etiology and Treatment of Schizophrenia","volume":"6","author":"Rich","year":"2015","journal-title":"Front. Endocrinol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/4\/908\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:17:01Z","timestamp":1760134621000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/4\/908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,9]]},"references-count":334,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["jcm11040908"],"URL":"https:\/\/doi.org\/10.3390\/jcm11040908","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,9]]}}}