{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:53:59Z","timestamp":1791615239739,"version":"4.3.4"},"reference-count":39,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Health and Welfare Surcharge of Tobacco Products","award":["MOHW107-TDU-B-212-114020, MOHW108-TDU-B-212-124020, MOHW109-TDU-B-212-134020, MOHW110-TDU-B-212-144020"],"award-info":[{"award-number":["MOHW107-TDU-B-212-114020, MOHW108-TDU-B-212-124020, MOHW109-TDU-B-212-134020, MOHW110-TDU-B-212-144020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>We investigate whether cigarette smoking is associated with survival in patients with colorectal cancer (CRC) through a nationwide population-based cohort study in Taiwan. The Taiwan Cancer Registry and National Health Insurance Research Database were used to identify data from patients with CRC from 2011 to 2017. Tobacco use was evaluated based on the smoking status, intensity, and duration before cancer diagnosis. A total of 18,816 patients was included. A Kaplan\u2013Meier survival analysis indicated smoking to be significantly associated with the CRC mortality risk (log-rank p = 0.0001). A multivariable Cox model indicated that smoking patients had a 1.11-fold higher mortality risk (HR = 1.11, 95% CI = 1.05\u20131.19) than nonsmoking patients did. This increased risk was also present in patients with CRC who smoked 11\u201320 cigarettes per day (HR = 1.16; 95% CI = 1.07\u20131.26) or smoked for &gt;30 years (HR = 1.14; 95% CI = 1.04\u20131.25). Stratified analyses of sex and cancer subsites indicated that the effects of smoking were higher in male patients and in those with colon cancer. Our results indicate that cigarette smoking is significantly associated with poor survival in patients with CRC. An integrated smoking cessation campaign is warranted to prevent CRC mortality.<\/jats:p>","DOI":"10.3390\/jcm11040913","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T21:22:15Z","timestamp":1644441735000},"page":"913","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Cigarette Smoking Associated with Colorectal Cancer Survival: A Nationwide, Population-Based Cohort Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Yu-Min","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Division of General Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei 11031, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7275-2661","authenticated-orcid":false,"given":"Po-Li","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Division of Colorectal Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei Medical University, Taipei 11031, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5925-8477","authenticated-orcid":false,"given":"Chung-Han","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Chi-Mei Medical Center, Tainan 71004, Taiwan"},{"name":"Department of Information Management, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6483-1100","authenticated-orcid":false,"given":"Chih-Ching","family":"Yeh","sequence":"additional","affiliation":[{"name":"Master Program in Applied Epidemiology, College of Public Health, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan"},{"name":"School of Public Health, College of Public Health, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Department of Public Health, College of Public Health, China Medical University, Taichung 40402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.14309\/ajg.0000000000000803","article-title":"Smoking and Colorectal Cancer Risk, Overall and by Molecular Subtypes: A Meta-Analysis","volume":"115","author":"Botteri","year":"2020","journal-title":"Am. 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