{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T13:33:01Z","timestamp":1785850381875,"version":"3.56.0"},"reference-count":54,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deutsche Gesellschaft f\u00fcr Muskelkranke e.V., DGM (German Society for Muscle Diseases e.V.) Freiburg, Germany","award":["none"],"award-info":[{"award-number":["none"]}]},{"name":"Stiftung f\u00fcr Medizinische Wissenschaft, Frankfurt am Main","award":["none"],"award-info":[{"award-number":["none"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Pain is a common symptom in patients with amyotrophic lateral sclerosis (ALS). Coping plays a central role in adjustment to pain. Objective: This study evaluates the use of different pain coping strategies in patients with ALS and investigates the interplay of maladaptive coping, and the patient\u2019s affective state and pain. Methods: One hundred and fifty ALS patients from three German outpatient clinics completed the Brief Pain Inventory (BPI), the ALS-Functional Rating Scale-Extension (ALSFRS-EX), the ALS Depression Inventory (ADI-12), the subscale \u201cemotional functioning\u201d of the ALS Assessment Questionnaire (ALSAQ-40) and the Coping Strategies Questionnaire (CSQ). Based upon the results of correlational analyses, multiple regression analyses were performed to identify predictors of pain severity and to explore factors contributing to maladaptive coping. Results: Pain was prevalent in 56% (n = 84) of the patients. Patients applied different adaptive coping strategies as well as the maladaptive strategy \u201ccatastrophizing\u201d. Regression analysis indicated that the CSQ-subscale \u201ccatastrophizing\u201d significantly predicted pain intensity, explaining 34.0% of the variance (p &lt; 0.001). Pain-related catastrophizing was associated with higher pain-related functional impairments and worse emotional functioning. The ADI-12 sum score as an indicator for depressive symptoms contributed significantly to the maladaptive coping strategy \u201ccatastrophizing\u201d (p &lt; 0.001) and explained 40.8% of the variance. Conclusion: Patients with ALS apply different strategies to cope with pain. Catastrophizing is an important determinant of higher pain intensity ratings and is associated with higher pain interferences and decreased emotional well-being. Pain-related catastrophizing is promoted by depressive symptoms. Catastrophizing and depressive symptoms thus represent important targets of individualized pain-management strategies.<\/jats:p>","DOI":"10.3390\/jcm11040944","type":"journal-article","created":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T21:08:43Z","timestamp":1644786523000},"page":"944","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pain-Related Coping Behavior in ALS: The Interplay between Maladaptive Coping, the Patient\u2019s Affective State and Pain"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8162-3490","authenticated-orcid":false,"given":"Ina","family":"Schlichte","sequence":"first","affiliation":[{"name":"Department of Neurology, Otto-von-Guericke University, 39120 Magdeburg, Germany"},{"name":"Department of Neurology, Diakonissenanstalt, 24939 Flensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Petri","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hannover Medical School, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Dengler","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hannover Medical School, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Meyer","sequence":"additional","affiliation":[{"name":"Center for ALS and Other Motor Neuron Disorders, Department of Neurology, Charit\u00e9-Universit\u00e4tsmedizin, 13353 Berlin, Germany"},{"name":"Ambulanzpartner Soziotechnologie APST GmbH, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiden","family":"Haghikia","sequence":"additional","affiliation":[{"name":"Department of Neurology, Otto-von-Guericke University, 39120 Magdeburg, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany"},{"name":"Center for Behavioral Brain Sciences (CBBS), 39106 Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Vielhaber","sequence":"additional","affiliation":[{"name":"Department of Neurology, Otto-von-Guericke University, 39120 Magdeburg, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Vogt","sequence":"additional","affiliation":[{"name":"Department of Neurology, Otto-von-Guericke University, 39120 Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s00115-017-0293-3","article-title":"Todesursachen bei amyotropher Lateralsklerose: Ergebnisse aus dem ALS-Register Rheinland-Pfalz","volume":"88","author":"Wolf","year":"2017","journal-title":"Nervenarzt"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Requardt, M.V., G\u00f6rlich, D., Grehl, T., and Boentert, M. 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