{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:13:59Z","timestamp":1790115239565,"version":"4.0.1"},"reference-count":39,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>We evaluated in this randomised, double-blind clinical trial the efficacy of melatonin as a prophylactic treatment for prevention of SARS-CoV-2 infection among healthcare workers at high risk of SARS-CoV-2 exposure. Healthcare workers fulfilling inclusion criteria were recruited in five hospitals in Spain and were randomised 1:1 to receive melatonin 2 mg administered orally for 12 weeks or placebo. The main outcome was the number of SARS-CoV-2 infections. A total of 344 volunteers were screened, and 314 were randomised: 151 to placebo and 163 to melatonin; 308 received the study treatment (148 placebo; 160 melatonin). We detected 13 SARS-CoV-2 infections, 2.6% in the placebo arm and 5.5% in the melatonin arm (p = 0.200). A total of 294 adverse events were detected in 127 participants (139 in placebo; 155 in melatonin). We found a statistically significant difference in the incidence of adverse events related to treatment: 43 in the placebo arm and 67 in the melatonin arm (p = 0.040), and in the number of participants suffering from somnolence related to treatment: 8.8% (n = 14) in the melatonin versus 1.4% (n = 2) in the placebo arm (p = 0.008). No severe adverse events related to treatment were reported. We cannot confirm our hypothesis that administration of melatonin prevents the development of SARS-CoV-2 infection in healthcare workers.<\/jats:p>","DOI":"10.3390\/jcm11041139","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T20:47:45Z","timestamp":1645476465000},"page":"1139","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Melatonin in the Prophylaxis of SARS-CoV-2 Infection in Healthcare Workers (MeCOVID): A Randomised Clinical Trial"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4831-9374","authenticated-orcid":false,"given":"Irene","family":"Garc\u00eda-Garc\u00eda","sequence":"first","affiliation":[{"name":"Clinical Pharmacology Department, La Paz University Hospital-IdiPAZ, 28046 Madrid, Spain"},{"name":"Spanish Clinical Research Network (SCReN), 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Seco-Meseguer","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Department, La Paz University Hospital-IdiPAZ, 28046 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1050-4520","authenticated-orcid":false,"given":"Pilar","family":"Ruiz-Seco","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Infanta Sof\u00eda University Hospital, 28702 San Sebasti\u00e1n de los Reyes, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema","family":"Navarro-Jimenez","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Infanta Sof\u00eda University Hospital, 28702 San Sebasti\u00e1n de los Reyes, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Mart\u00ednez-Porqueras","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Espinosa-D\u00edaz","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6207-0712","authenticated-orcid":false,"given":"Juan Jos\u00e9","family":"Ortega-Alb\u00e1s","sequence":"additional","affiliation":[{"name":"Sleep Unit, Hospital General Universitario de Castell\u00f3n, 12004 Castell\u00f3n de la Plana, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1igo","family":"Sagastagoitia","sequence":"additional","affiliation":[{"name":"Internal 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Spain"},{"name":"School of Medicine, Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8584-3263","authenticated-orcid":false,"given":"Alberto M.","family":"Borobia","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Department, La Paz University Hospital-IdiPAZ, 28046 Madrid, Spain"},{"name":"Spanish Clinical Research Network (SCReN), 28046 Madrid, Spain"},{"name":"School of Medicine, Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas (CIBERINFEC), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"ref_1","unstructured":"World Health 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