{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T22:56:40Z","timestamp":1775170600208,"version":"3.50.1"},"reference-count":22,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Serum procalcitonin (PCT) has been reported as a potential biomarker to predict the severity of acute cholangitis (AC) or the need for urgent biliary decompression. This study aimed to identify and summarize the existing research about serum PCT and the severity of AC, and to find gaps towards which future studies can be targeted. Following the PRISMA extension for scoping reviews, MEDLINE, EMBASE, and Google Scholar were searched for all peer-reviewed articles with relevant keywords including \u201ccholangitis\u201d and \u201cprocalcitonin\u201d from their inception to 13 July 2021. We identified six studies. All the studies employed a case-control design and aimed to evaluate the usefulness of serum PCT to predict the severity of AC with key identified outcomes. While the potential cut-off values of serum PCT for severe AC ranged from 1.8\u20133.1 ng\/mL, studies used different severity criteria and the definition of urgent biliary decompression. No studies proposed cut-off PCT values for the need for urgent biliary decompression. This scoping review identified the current level of evidence regarding the usefulness of serum PCT in assessing the severity of AC. Further clinical research is warranted with a focus on standardized outcome measures employing prospective or experimental designs.<\/jats:p>","DOI":"10.3390\/jcm11051155","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T22:34:30Z","timestamp":1645569270000},"page":"1155","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Procalcitonin to Predict Severity of Acute Cholangitis and Need for Urgent Biliary Decompression: Systematic Scoping Review"],"prefix":"10.3390","volume":"11","author":[{"given":"Krixie","family":"Silangcruz","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Hawai\u2019i, Honolulu, HI 96813, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0224-7501","authenticated-orcid":false,"given":"Yoshito","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Hawai\u2019i, Honolulu, HI 96813, USA"},{"name":"Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 7008558, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1630-5661","authenticated-orcid":false,"given":"Torrey","family":"Czech","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Hawai\u2019i, Honolulu, HI 96813, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiko","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Hawai\u2019i, Honolulu, HI 96813, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Yess","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Hawai\u2019i, Honolulu, HI 96813, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/ans.13981","article-title":"Acute cholangitis: Current concepts","volume":"87","author":"Wah","year":"2017","journal-title":"ANZ J. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.suc.2018.11.002","article-title":"Cholangitis: Causes, Diagnosis, and Management","volume":"99","author":"Sulzer","year":"2019","journal-title":"Surg. Clin. N. Am."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00534-006-1152-y","article-title":"Definitions, pathophysiology, and epidemiology of acute cholangitis and cholecystitis: Tokyo Guidelines","volume":"14","author":"Kimura","year":"2007","journal-title":"J. Hepatobil. Pancreat. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jviscsurg.2019.05.007","article-title":"Acute cholangitis: Diagnosis and management","volume":"156","author":"Sokal","year":"2019","journal-title":"J. Visc. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ccc.2019.08.003","article-title":"Procalcitonin: Where Are We Now?","volume":"36","author":"Hamade","year":"2020","journal-title":"Crit. Care Clin."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cca.2019.06.010","article-title":"Procalcitonin: Between evidence and critical issues","volume":"496","author":"Aloisio","year":"2019","journal-title":"Clin. Chim. Acta"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Yunus, I., Fasih, A., and Wang, Y. (2018). The use of procalcitonin in the determination of severity of sepsis, patient outcomes and infection characteristics. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0206527"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S1473-3099(12)70323-7","article-title":"Procalcitonin as a diagnostic marker for sepsis: A systematic review and meta-analysis","volume":"13","author":"Wacker","year":"2013","journal-title":"Lancet Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/jhbp.515","article-title":"Tokyo Guidelines 2018: Diagnostic criteria and severity grading of acute cholecystitis (with videos)","volume":"25","author":"Yokoe","year":"2018","journal-title":"J. Hepatobil. Pancreat. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.7754\/Clin.Lab.2012.120520","article-title":"Usefulness of procalcitonin for severity assessment in patients with acute cholangitis","volume":"59","author":"Hamano","year":"2013","journal-title":"Clin. Lab."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/jhbp.132","article-title":"Procalcitonin as a useful biomarker for determining the need to perform emergency biliary drainage in cases of acute cholangitis","volume":"21","author":"Shinya","year":"2014","journal-title":"J. Hepatobil. Pancreat. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1007\/s00535-016-1278-x","article-title":"Procalcitonin is a useful biomarker to predict severe acute cholangitis: A single-center prospective study","volume":"52","author":"Umefune","year":"2017","journal-title":"J. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/jhbp.420","article-title":"IL-7 and procalcitonin are useful biomarkers in the comprehensive evaluation of the severity of acute cholangitis","volume":"24","author":"Suwa","year":"2017","journal-title":"J. Hepatobil. Pancreat. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1007\/s10620-018-4963-1","article-title":"Procalcitonin as a Decision-Supporting Marker of Urgent Biliary Decompression in Acute Cholangitis","volume":"63","author":"Lee","year":"2018","journal-title":"Dig. Dis. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00534-012-0568-9","article-title":"TG13 diagnostic criteria and severity grading of acute cholecystitis (with videos)","volume":"20","author":"Yokoe","year":"2013","journal-title":"J. Hepatobil. Pancreat. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jclinepi.2020.03.016","article-title":"Reporting scoping reviews-PRISMA ScR extension","volume":"123","author":"McGowan","year":"2020","journal-title":"J. Clin. Epidemiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"ref_18","first-page":"428","article-title":"The role of procalcitonin in patients with different severity grades of acute cholangitis","volume":"20","author":"Lyu","year":"2014","journal-title":"Chin. J. Hepatobil. Surg."},{"key":"ref_19","first-page":"809","article-title":"Evaluation of the Usefulness of Procalcitonin as a Biomarker for the Diagnosis of Acute Cholangitis","volume":"40","author":"Korekawa","year":"2020","journal-title":"J. Abdom. Emerg. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/jhbp.519","article-title":"Tokyo Guidelines 2018: Management bundles for acute cholangitis and cholecystitis","volume":"25","author":"Mayumi","year":"2018","journal-title":"J. Hepatobil. Pancreat. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s00534-006-1156-7","article-title":"Diagnostic criteria and severity assessment of acute cholangitis: Tokyo Guidelines","volume":"14","author":"Wada","year":"2007","journal-title":"J. Hepatobil. Pancreat. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/jhbp.512","article-title":"Tokyo Guidelines 2018: Diagnostic criteria and severity grading of acute cholangitis (with videos)","volume":"25","author":"Kiriyama","year":"2018","journal-title":"J. Hepatobil. Pancreat. 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