{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T18:08:44Z","timestamp":1785866924477,"version":"3.56.0"},"reference-count":39,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Changes in the cornea can influence outcomes in patients with primary open-angle glaucoma (POAG). We aimed to evaluate the relevance of changes in corneal biomechanics and intraocular pressure (IOP) in patients undergoing non-penetrating deep sclerectomy (NPDS) with the Esnoper V2000 implant\u00ae (AJL Ophthalmic S.A., Gasteiz, Spain). We included 42 eyes of 42 patients with POAG scheduled for NPDS with the Esnoper V2000 implant. Biomechanical properties were measured by Ocular Response Analyzer\u00ae G3 (ORA; Reichert Inc., Depew, NY, USA). Corneal hysteresis (CH), corneal resistance factor (CRF), corneal compensated IOP (IOPcc), and Goldmann-correlated IOP (IOPg) were measured the day before surgery and on day 1, 7, and 30 and 2 and 3 months after surgery. CH initially increased, fell below the presurgical value at 30 days after the surgery, and increased again at 2 and 3 months. CRF, IOPcc, and IOPg decreased on the first day after surgery, then followed a trend of increasing but stayed below pre-surgery levels. All values reached statistical significance. While observed changes in corneal biomechanics after NPDS and Esnoper V2000 implant were significant, more studies are needed if we are to understand their influence on corneal biomechanics and their clinical relevance in POAG.<\/jats:p>","DOI":"10.3390\/jcm11051216","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T07:22:35Z","timestamp":1645687355000},"page":"1216","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Modification of Corneal Biomechanics and Intraocular Pressure Following Non-Penetrating Deep Sclerectomy"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6134-0629","authenticated-orcid":false,"given":"Mar\u00eda Dolores","family":"D\u00edaz-Barreda","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Hospital Cl\u00ednico Universitario Lozano Blesa, 50009 Zaragoza, Spain"},{"name":"Department of Surgery, School of Medicine, University of Zaragoza, 50009 Zaragoza, Spain"},{"name":"Aragon Health Research Institute (IIS Arag\u00f3n), 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"S\u00e1nchez-Mar\u00edn","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Cl\u00ednico Universitario Lozano Blesa, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0798-5565","authenticated-orcid":false,"given":"Ana","family":"Boned-Murillo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Cl\u00ednico Universitario Lozano Blesa, 50009 Zaragoza, Spain"},{"name":"Department of Surgery, School of Medicine, University of Zaragoza, 50009 Zaragoza, Spain"},{"name":"Aragon Health Research Institute (IIS Arag\u00f3n), 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itziar","family":"P\u00e9rez-Navarro","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Cl\u00ednico Universitario Lozano Blesa, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juana","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Cl\u00ednico Universitario Lozano Blesa, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Pardina-Claver","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Cl\u00ednico Universitario Lozano Blesa, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Cl\u00ednico Universitario Lozano Blesa, 50009 Zaragoza, Spain"},{"name":"Department of Surgery, School of Medicine, University of Zaragoza, 50009 Zaragoza, Spain"},{"name":"Aragon Health Research Institute (IIS Arag\u00f3n), 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4804-2555","authenticated-orcid":false,"given":"Francisco Javier","family":"Ascaso","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Cl\u00ednico Universitario Lozano Blesa, 50009 Zaragoza, Spain"},{"name":"Department of Surgery, School of Medicine, University of Zaragoza, 50009 Zaragoza, Spain"},{"name":"Aragon Health Research Institute (IIS Arag\u00f3n), 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Cl\u00ednico Universitario Lozano Blesa, 50009 Zaragoza, Spain"},{"name":"Department of Surgery, School of Medicine, University of Zaragoza, 50009 Zaragoza, Spain"},{"name":"Aragon Health Research Institute (IIS Arag\u00f3n), 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/ICU.0000000000000647","article-title":"Vision 2020: Where are we?","volume":"31","author":"Bourne","year":"2020","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_2","first-page":"225","article-title":"The Diagnosis and Treatment of Glaucoma","volume":"117","author":"Schuster","year":"2020","journal-title":"Dtsch Arztebl Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.optom.2016.02.003","article-title":"Glaucoma history and risk factors","volume":"10","author":"McMonnies","year":"2017","journal-title":"J. Optom."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"321","DOI":"10.22336\/rjo.2019.51","article-title":"The importance of corneal assessment in a glaucoma suspect-A review","volume":"63","author":"Potop","year":"2019","journal-title":"Rom. J. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.survophthal.2019.02.011","article-title":"Intraocular pressure measurement after corneal transplantation","volume":"64","author":"Chan","year":"2019","journal-title":"Surv. Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.5005\/jp-journals-10008-1103","article-title":"Ocular Response Analyzer","volume":"6","author":"Kaushik","year":"2012","journal-title":"J. Curr. Glaucoma Pract."},{"key":"ref_7","unstructured":"del Buey Sayas, M.\u00c1., and Peris Mart\u00ednez, C. (2014). Biomec\u00e1nica y Arquitectura Corneal, Elsevier Monografia Secoir."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.jcrs.2014.03.021","article-title":"In vivo characterization of corneal biomechanics","volume":"40","year":"2014","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jcrs.2004.09.031","article-title":"Influence of corneal biomechanical properties on intraocular pressure measurement: Quantitative analysis","volume":"3","author":"Liu","year":"2005","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/IJG.0b013e31824cafc9","article-title":"Influence of corneal biomechanical properties on intraocular pressure differences between an air-puff tonometer and the Goldmann applanation tonometer","volume":"22","author":"Tranchina","year":"2013","journal-title":"J. Glaucoma"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3928\/1081597X-20160629-01","article-title":"Detection of Keratoconus With a New Biomechanical Index","volume":"32","author":"Vinciguerra","year":"2016","journal-title":"J. Refract. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s12938-019-0735-1","article-title":"A new method for detecting the outer corneal contour in images from an ultra-fast Scheimpflug camera","volume":"18","author":"Koprowski","year":"2019","journal-title":"Biomed. Eng. Online"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1097\/ICU.0000000000000130","article-title":"Corneal hysteresis and its relevance to glaucoma","volume":"26","author":"Deol","year":"2015","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Del Buey-Sayas, M., Lanchares-Sancho, E., Campins-Falc\u00f3, P., Pinazo-Dur\u00e1n, M.D., and Peris-Mart\u00ednez, C. (2021). Corneal Biomechanical Parameters and Central Corneal Thickness in Glaucoma Patients, Glaucoma Suspects, and a Healthy Population. J. Clin. Med., 10.","DOI":"10.3390\/jcm10122637"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.jcrs.2007.11.051","article-title":"Correlations between corneal hysteresis, intraocular pressure, and corneal central pachymetry","volume":"34","author":"Touboul","year":"2008","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.clae.2006.09.006","article-title":"The use of the Reichert ocular response analyser to establish the relationship between ocular hysteresis, corneal resistance factor and central corneal thickness in normal eyes","volume":"29","author":"Shah","year":"2006","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1007\/s10792-018-1011-2","article-title":"Corneal hysteresis and glaucoma","volume":"39","author":"Liang","year":"2019","journal-title":"Int. Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ajo.2017.12.018","article-title":"A Prospective Longitudinal Study to Investigate Corneal Hysteresis as a Risk Factor for Predicting Development of Glaucoma","volume":"187","author":"Susanna","year":"2018","journal-title":"Am. J. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"535","DOI":"10.5301\/ejo.5000955","article-title":"Relationship between corneal biomechanical properties and optic nerve head changes after deep sclerectomy","volume":"27","author":"Oblanca","year":"2017","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.ophtha.2019.07.023","article-title":"Corneal Biomechanics and Visual Field Progression in Eyes with Seemingly Well-Controlled Intraocular Pressure","volume":"126","author":"Susanna","year":"2019","journal-title":"Ophthalmology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1001\/archopht.120.6.714","article-title":"The Ocular Hypertension Treatment Study: Baseline factors that predict the onset of primary open-angle glaucoma","volume":"120","author":"Gordon","year":"2002","journal-title":"Arch Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.ajo.2009.01.008","article-title":"Recovery of corneal hysteresis after reduction of intraocular pressure in chronic primary angle-closure glaucoma","volume":"147","author":"Sun","year":"2009","journal-title":"Am. J. Ophthalmol."},{"key":"ref_23","first-page":"e495","article-title":"Effect of topical prostaglandin analogues on corneal hysteresis","volume":"93","author":"Teus","year":"2015","journal-title":"Acta Ophthalmol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3928\/1081597X-20111103-02","article-title":"Central corneal thickness and biomechanical changes after clear corneal phacoemulsification","volume":"28","author":"Ventura","year":"2012","journal-title":"J. Refract. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0039-6257(00)00110-7","article-title":"Human corneal thickness and its impact on intraocular pressure measures: A review and meta-analysis approach","volume":"44","author":"Doughty","year":"2000","journal-title":"Surv. Ophthalmol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/IJG.0000000000001144","article-title":"The Clinical Interpretation of Changes in Intraocular Pressure Measurements Using Goldmann Applanation Tonometry: A Review","volume":"28","author":"Pearce","year":"2019","journal-title":"J. Glaucoma"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1097\/IJG.0b013e318220daf0","article-title":"Assessment of corneal biomechanical properties in normal tension glaucoma and comparison with open-angle glaucoma, ocular hypertension, and normal eyes","volume":"21","author":"Saad","year":"2012","journal-title":"J. Glaucoma"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/01.ijg.0000212268.42606.97","article-title":"Evaluation of the influence of corneal biomechanical properties on intraocular pressure measurements using the ocular response analyzer","volume":"15","author":"Medeiros","year":"2006","journal-title":"J. Glaucoma"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1016\/j.jcrs.2008.08.017","article-title":"Corneal biomechanical properties and intraocular pressure changes after phacoemulsification and intraocular lens implantation","volume":"34","author":"Kucumen","year":"2008","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ajo.2007.05.023","article-title":"Changes in corneal hysteresis after clear corneal cataract surgery","volume":"144","author":"Hager","year":"2007","journal-title":"Am. J. Ophthalmol."},{"key":"ref_31","first-page":"7","article-title":"Corneal Biomechanical Changes Following Trabeculectomy, Phaco-trabeculectomy, Ahmed Glaucoma Valve Implantation and Phacoemulsification","volume":"9","author":"Pakravan","year":"2014","journal-title":"J. Ophthalmic Vis. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/IJG.0b013e3181aff419","article-title":"Modifications in corneal biomechanics and intraocular pressure after deep sclerectomy","volume":"19","author":"Iordanidou","year":"2010","journal-title":"J. Glaucoma"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1167\/iovs.06-0507","article-title":"Effect of 24-hour corneal biomechanical changes on intraocular pressure measurement","volume":"47","author":"Kida","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Konstantinidis, A., Panagiotopoulou, E.K., Panos, G.D., Sideroudi, H., Mehmet, A., and Labiris, G. (2021). The Effect of Antiglaucoma Procedures (Trabeculectomy vs. Ex-PRESS Glaucoma Drainage Implant) on the Corneal Biomechanical Properties. J. Clin. Med., 10.","DOI":"10.20944\/preprints202101.0073.v1"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/IJG.0000000000000538","article-title":"Differences in Corneal Biomechanics in Nonpenetrating Deep Sclerectomy and Deep Sclerectomy Reconverted into Trabeculectomy","volume":"26","author":"Casado","year":"2017","journal-title":"J. Glaucoma"},{"key":"ref_36","first-page":"525","article-title":"Recovery of corneal hysteresis after reduction of intraocular pressure in chronic primary angle-closure glaucoma","volume":"149","author":"Poostchi","year":"2009","journal-title":"Am. J. Ophthalmol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1136\/bjophthalmol-2016-308432","article-title":"The impact of chronic use of prostaglandin analogues on the biomechanical properties of the cornea in patients with primary open-angle glaucoma","volume":"101","author":"Meda","year":"2017","journal-title":"Br. J. Ophthalmol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s40123-013-0020-5","article-title":"Intraocular pressure effects of common topical steroids for post-cataract inflammation: Are they all the same?","volume":"2","author":"Pleyer","year":"2013","journal-title":"Ophthalmol. Ther."},{"key":"ref_39","first-page":"134","article-title":"Effects of pterygium on the biomechanical properties of the cornea: A pilot study","volume":"88","author":"Teus","year":"2013","journal-title":"Arch Soc. Esp. Oftalmol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/5\/1216\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:26:00Z","timestamp":1760135160000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/5\/1216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,24]]},"references-count":39,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["jcm11051216"],"URL":"https:\/\/doi.org\/10.3390\/jcm11051216","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,24]]}}}