{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T01:43:33Z","timestamp":1768009413528,"version":"3.49.0"},"reference-count":68,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Mortality in infarct-related cardiogenic shock (CS) remains high, reaching 40\u201350%. In refractory CS, active mechanical circulatory support devices including veno-arterial extracorporeal membrane oxygenation (VA-ECMO) are rapidly evolving. However, supporting evidence of VA-ECMO therapy in infarct-related CS is low. The current review aims to give an overview on the basics of VA-ECMO therapy, current evidence, ongoing trials, patient selection and potential complications.<\/jats:p>","DOI":"10.3390\/jcm11051256","type":"journal-article","created":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T20:47:17Z","timestamp":1645994837000},"page":"1256","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Extracorporeal Membrane Oxygenation in Infarct-Related Cardiogenic Shock"],"prefix":"10.3390","volume":"11","author":[{"given":"Anne","family":"Freund","sequence":"first","affiliation":[{"name":"Department of Internal Medicine\/Cardiology, Heart Center Leipzig, University of Leipzig, Str\u00fcmpellstr. 39, 04289 Leipzig, Germany"},{"name":"Leipzig Heart Institute, 04289 Leipzig, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), 10785 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Desch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology, Heart Center Leipzig, University of Leipzig, Str\u00fcmpellstr. 39, 04289 Leipzig, Germany"},{"name":"Leipzig Heart Institute, 04289 Leipzig, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), 10785 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine","family":"P\u00f6ss","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology, Heart Center Leipzig, University of Leipzig, Str\u00fcmpellstr. 39, 04289 Leipzig, Germany"},{"name":"Leipzig Heart Institute, 04289 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0591-7945","authenticated-orcid":false,"given":"Dmitry","family":"Sulimov","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology, Heart Center Leipzig, University of Leipzig, Str\u00fcmpellstr. 39, 04289 Leipzig, Germany"},{"name":"Leipzig Heart Institute, 04289 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Sandri","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology, Heart Center Leipzig, University of Leipzig, Str\u00fcmpellstr. 39, 04289 Leipzig, Germany"},{"name":"Leipzig Heart Institute, 04289 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Majunke","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology, Heart Center Leipzig, University of Leipzig, Str\u00fcmpellstr. 39, 04289 Leipzig, Germany"},{"name":"Leipzig Heart Institute, 04289 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0169-998X","authenticated-orcid":false,"given":"Holger","family":"Thiele","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Cardiology, Heart Center Leipzig, University of Leipzig, Str\u00fcmpellstr. 39, 04289 Leipzig, Germany"},{"name":"Leipzig Heart Institute, 04289 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1001\/jama.297.17.1892","article-title":"Decline in Rates of Death and Heart Failure in Acute Coronary Syndromes, 1999\u20132006","volume":"297","author":"Fox","year":"2007","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S0735-1097(00)00879-2","article-title":"Cardiogenic shock complicating acute myocardial infarction--etiologies, management and outcome: A report from the SHOCK Trial Registry","volume":"36","author":"Hochman","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1056\/NEJMc1213513","article-title":"Intraaortic Balloon Support for Cardiogenic Shock","volume":"368","author":"Kleber","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jacc.2016.10.022","article-title":"Percutaneous Mechanical Circulatory Support Versus Intra-Aortic Balloon Pump in Cardiogenic Shock After Acute Myocardial Infarction","volume":"69","author":"Ouweneel","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1056\/NEJM199908263410901","article-title":"Early revascularization in acute myocardial infarction complicated by cardiogenic shock. SHOCK Investigators. Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock","volume":"341","author":"Hochman","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1056\/NEJMoa1710261","article-title":"PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock","volume":"377","author":"Thiele","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/MAT.0000000000000475","article-title":"Extracorporeal Life Support Organization Registry International Report 2016","volume":"63","author":"Thiagarajan","year":"2016","journal-title":"ASAIO J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S366","DOI":"10.1161\/CIR.0000000000000916","article-title":"Part 3: Adult Basic and Advanced Life Support: 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care","volume":"142","author":"Panchal","year":"2020","journal-title":"Circulation"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/ijcp.12380","article-title":"Extracorporal life support (ECLS) in acute ischaemic cardiogenic shock","volume":"68","author":"Sattler","year":"2014","journal-title":"Int. J. Clin. Pr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1097\/CCM.0b013e3181e8acf7","article-title":"Early extracorporeal membrane oxygenator-assisted primary percutaneous coronary intervention improved 30-day clinical outcomes in patients with ST-segment elevation myocardial infarction complicated with profound cardiogenic shock","volume":"38","author":"Sheu","year":"2010","journal-title":"Crit. Care Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1016\/j.jacc.2019.02.044","article-title":"Extracorporeal Life Support in Cardiogenic Shock Complicating Acute Myocardial Infarction","volume":"73","author":"Brunner","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/eurjhf\/hfs182","article-title":"The impact of multivessel disease with and without a co-existing chronic total occlusion on short- and long-term mortality in ST-elevation myocardial infarction patients with and without cardiogenic shock","volume":"15","author":"Hoebers","year":"2013","journal-title":"Eur. J. Heart Fail."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1007\/s00392-020-01778-8","article-title":"Outcome of patients treated with extracorporeal life support in cardiogenic shock complicating acute myocardial infarction: 1-year result from the ECLS-Shock study","volume":"110","author":"Lackermair","year":"2020","journal-title":"Clin. Res. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","article-title":"2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevationThe Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC)","volume":"39","author":"Ibanez","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.jcin.2021.02.046","article-title":"Mechanical Circulatory Support as a Bridge to Definitive Treatment in Post-Infarction Ventricular Septal Rupture","volume":"14","author":"Ronco","year":"2021","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"530.e1","DOI":"10.1016\/j.jcrc.2012.02.012","article-title":"Extracorporeal membrane oxygenation\u2013assisted primary percutaneous coronary intervention may improve survival of patients with acute myocardial infarction complicated by profound cardiogenic shock","volume":"27","author":"Tsao","year":"2012","journal-title":"J. Crit. Care"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00392-016-1068-8","article-title":"Outcome of elderly undergoing extracorporeal life support in refractory cardiogenic shock","volume":"106","author":"Graf","year":"2017","journal-title":"Clin. Res. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1016\/j.jacc.2017.02.027","article-title":"Risk Stratification for Patients in Cardiogenic Shock After Acute Myocardial Infarction","volume":"69","author":"Fuernau","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/ejhf.260","article-title":"Clinical picture and risk prediction of short-term mortality in cardiogenic shock","volume":"17","author":"Harjola","year":"2015","journal-title":"Eur. J. Heart Fail."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1093\/ehjacc\/zuab054","article-title":"Comparison of risk prediction models in infarct-related cardiogenic shock","volume":"10","author":"Freund","year":"2021","journal-title":"Eur. Heart J. Acute Cardiovasc. Care"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1093\/eurheartj\/ehab110","article-title":"The novel cystatin C, lactate, interleukin-6, and N-terminal pro-B-type natriuretic peptide (CLIP)-based mortality risk score in cardiogenic shock after acute myocardial infarction","volume":"42","author":"Ceglarek","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s00134-016-4223-9","article-title":"The ENCOURAGE mortality risk score and analysis of long-term outcomes after VA-ECMO for acute myocardial infarction with cardiogenic shock","volume":"42","author":"Muller","year":"2016","journal-title":"Intensiv. Care Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1093\/eurheartj\/ehv194","article-title":"Predicting survival after ECMO for refractory cardiogenic shock: The survival after veno-arterial-ECMO (SAVE)-score","volume":"36","author":"Schmidt","year":"2015","journal-title":"Eur. Heart J."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Semaan, C., Charbonnier, A., Pasco, J., Darwiche, W., Etienne, C.S., Bailleul, X., Bourguignon, T., Fauchier, L., Angoulvant, D., and Ivanes, F. (2021). Risk Scores in ST-Segment Elevation Myocardial Infarction Patients with Refractory Cardiogenic Shock and Veno-Arterial Extracorporeal Membrane Oxygenation. J. Clin. Med., 10.","DOI":"10.3390\/jcm10050956"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1177\/2048872618789052","article-title":"Development and validation of a prognostic model for survival in patients treated with venoarterial extracorporeal membrane oxygenation: The PREDICT VA-ECMO score","volume":"8","author":"Wengenmayer","year":"2018","journal-title":"Eur. Heart J. Acute Cardiovasc. Care"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/ccd.28329","article-title":"SCAI clinical expert consensus statement on the classification of cardiogenic shock: This document was endorsed by the American College of Cardiology (ACC), the American Heart Association (AHA), the Society of Critical Care Medicine (SCCM), and the Society of Thoracic Surgeons (STS) in April 2019","volume":"94","author":"Baran","year":"2019","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/ehjacc\/zuaa035","article-title":"Influence of age and shock severity on short-term survival in patients with cardiogenic shock","volume":"10","author":"Jentzer","year":"2021","journal-title":"Eur. Heart J. Acute Cardiovasc. Care"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"E213","DOI":"10.1002\/ccd.28707","article-title":"Application of the SCAI classification in a cohort of patients with cardiogenic shock","volume":"96","author":"Schrage","year":"2020","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1016\/j.jacc.2019.07.077","article-title":"Cardiogenic Shock Classification to Predict Mortality in the Cardiac Intensive Care Unit","volume":"74","author":"Jentzer","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/ccd.29319","article-title":"Prospective validation of the SCAI shock classification: Single center analysis","volume":"96","author":"Baran","year":"2020","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_32","unstructured":"Naidu, S.S., Baran, D.A., Jentzer, J.C., Hollenberg, S.M., van Diepen, S., Basir, M.B., Grines, C.L., Diercks, D.B., Hall, S., and Kapur, N.K. (2022). SCAI SHOCK Stage Classification Expert Consensus Update: A Review and Incorporation of Validation Studies: This statement was endorsed by the American College of Cardiology (ACC), American College of Emergency Physicians (ACEP), American Heart Association (AHA), European Society of Cardiology (ESC) Association for Acute Cardiovascular Care (ACVC), International Society for Heart and Lung Transplantation (ISHLT), Society of Critical Care Medicine (SCCM), and Society of Thoracic Surgeons (STS) in December 2021. J. Am. Coll. Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.jcin.2021.03.048","article-title":"Association Between Timing of Extracorporeal Membrane Oxygenation and Clinical Outcomes in Refractory Cardiogenic Shock","volume":"14","author":"Lee","year":"2021","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1253\/circj.CJ-20-0259","article-title":"Optimal Timing of Venoarterial-Extracorporeal Membrane Oxygenation in Acute Myocardial Infarction Patients Suffering From Refractory Cardiogenic Shock","volume":"84","author":"Choi","year":"2020","journal-title":"Circ. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e000590","DOI":"10.1161\/JAHA.113.000590","article-title":"Trends in incidence, management, and outcomes of cardiogenic shock complicating ST-elevation myocardial infarction in the United States","volume":"3","author":"Kolte","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.jchf.2020.08.012","article-title":"Complete Hemodynamic Profiling With Pulmonary Artery Catheters in Cardiogenic Shock Is Associated With Lower In-Hospital Mortality","volume":"8","author":"Garan","year":"2020","journal-title":"JACC Heart Fail."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1540-8191.1999.tb00996.x","article-title":"Pharmacological Criteria for Ventricular Assist Device Insertion Following Postcardiotomy Shock: Experience with the Abiomed BVS System","volume":"14","author":"Samuels","year":"1999","journal-title":"J. Card. Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1056\/NEJMoa0907118","article-title":"Comparison of dopamine and norepinephrine in the treatment of shock","volume":"362","author":"Biston","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s13054-019-2605-4","article-title":"Epinephrine, inodilator, or no inotrope in venoarterial extracorporeal membrane oxygenation implantation: A single-center experience","volume":"23","author":"Zotzmann","year":"2019","journal-title":"Crit. Care"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1186\/s13054-014-0675-x","article-title":"Combination of extracorporeal membrane oxygenation and continuous renal replacement therapy in critically ill patients: A systematic review","volume":"18","author":"Chen","year":"2014","journal-title":"Crit. Care"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/MAT.0b013e3182579218","article-title":"A multicenter international survey of renal supportive therapy during ECMO: The Kidney Intervention During Extracorporeal Membrane Oxygenation (KIDMO) group","volume":"58","author":"Fleming","year":"2012","journal-title":"ASAIO J."},{"key":"ref_42","first-page":"e232","article-title":"Contemporary management of cardiogenic shock\u2014A scientific statement","volume":"136","author":"Katz","year":"2017","journal-title":"Circulation"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.resuscitation.2017.06.006","article-title":"Etiological diagnoses of out-of-hospital cardiac arrest survivors admitted to the intensive care unit: Insights from a French registry","volume":"117","author":"Geri","year":"2017","journal-title":"Resuscitation"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S0140-6736(08)60958-7","article-title":"Cardiopulmonary resuscitation with assisted extracorporeal life-support versus conventional cardiopulmonary resuscitation in adults with in-hospital cardiac arrest: An observational study and propensity analysis","volume":"372","author":"Chen","year":"2008","journal-title":"Lancet"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/CCM.0b013e3181feb339","article-title":"Extracorporeal cardiopulmonary resuscitation in patients with inhospital cardiac arrest: A comparison with conventional cardiopulmonary resuscitation","volume":"39","author":"Shin","year":"2011","journal-title":"Crit. Care Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.resuscitation.2018.07.029","article-title":"Extracorporeal cardiopulmonary resuscitation for cardiac arrest: A systematic review","volume":"131","author":"Holmberg","year":"2018","journal-title":"Resuscitation"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1016\/S0140-6736(20)32338-2","article-title":"Advanced reperfusion strategies for patients with out-of-hospital cardiac arrest and refractory ventricular fibrillation (ARREST): A phase 2, single centre, open-label, randomised controlled trial","volume":"396","author":"Yannopoulos","year":"2020","journal-title":"Lancet"},{"key":"ref_48","unstructured":"Belohlavek, J. (2021, January 15\u201317). Hyperinvasive Approach In Refractory Out-of-hospital Cardiac Arrest: An Open-label Randomized Controlled Trial. Proceedings of the American College of Cardiology\u2019s 70th Annual Scientific Session & Expo, Atlanta, GA, USA."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1001\/jama.292.13.1555","article-title":"Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes","volume":"292","author":"Rao","year":"2004","journal-title":"JAMA"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1007\/s00134-017-4803-3","article-title":"The ICM research agenda on extracorporeal life support","volume":"43","author":"Combes","year":"2017","journal-title":"Intensiv. Care Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jcrc.2017.02.014","article-title":"Anticoagulation practices and the prevalence of major bleeding, thromboembolic events, and mortality in venoarterial extracorporeal membrane oxygenation: A systematic review and meta-analysis","volume":"39","author":"Sy","year":"2017","journal-title":"J. Crit. Care"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3988\/jcn.2015.11.4.383","article-title":"Neurologic Complications of Extracorporeal Membrane Oxygenation","volume":"11","author":"Nasr","year":"2015","journal-title":"J. Clin. Neurol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.jcin.2020.02.042","article-title":"Frequency and Impact of Bleeding on Outcome in Patients With Cardiogenic Shock","volume":"13","author":"Freund","year":"2020","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_54","unstructured":"Extracorporeal Life Support Organization (2021, December 04). ECLS Registry Report: International Summary. Available online: https:\/\/www.elso.org\/Portals\/0\/Files\/Reports\/2017\/International%20Summary%20January%202017.pdf."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/aor.12979","article-title":"Incidence, Risk Factors, and Outcomes of Hyperbilirubinemia in Adult Cardiac Patients Supported by Veno-Arterial ECMO","volume":"42","author":"Lyu","year":"2017","journal-title":"Artif. Organs"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Omar, H.R., Mirsaeidi, M., Socias, S., Sprenker, C., Caldeira, C., Camporesi, E.M., and Mangar, D. (2015). Plasma Free Hemoglobin Is an Independent Predictor of Mortality among Patients on Extracorporeal Membrane Oxygenation Support. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0124034"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"E122","DOI":"10.1002\/ccd.29595","article-title":"Management of dead space thrombosis during decannulation of peripherally inserted venoarterial extracorporeal membrane oxygenation","volume":"98","author":"Sulimov","year":"2021","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/MAT.0b013e31820e121c","article-title":"Left Ventricular Mechanical Support with Impella Provides More Ventricular Unloading in Heart Failure Than Extracorporeal Membrane Oxygenation","volume":"57","author":"Kawashima","year":"2011","journal-title":"ASAIO J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ijcard.2020.02.004","article-title":"Strategies of left ventricular unloading during VA-ECMO support: A network meta-analysis","volume":"312","author":"Baldetti","year":"2020","journal-title":"Int. J. Cardiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1161\/CIRCULATIONAHA.120.048792","article-title":"Left Ventricular Unloading Is Associated With Lower Mortality in Patients With Cardiogenic Shock Treated With Venoarterial Extracorporeal Membrane Oxygenation: Results From an International, Multicenter Cohort Study","volume":"142","author":"Schrage","year":"2020","journal-title":"Circulation"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1525-1594.2007.00337.x","article-title":"The Acute Effect of Intra-aortic Balloon Counterpulsation During Extracorporeal Life Support: An Experimental Study","volume":"31","author":"Sauren","year":"2007","journal-title":"Artif. Organs"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jjcc.2021.10.011","article-title":"Prognostic significance of intra-aortic balloon pumping support in patients with acute myocardial infarction and veno-arterial extracorporeal membrane oxygenation therapy","volume":"79","author":"Kida","year":"2021","journal-title":"J. Cardiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1016\/j.jcin.2021.09.011","article-title":"Atrial Septostomy for Left Ventricular Unloading During Extracorporeal Membrane Oxygenation for Cardiogenic Shock: Animal Model","volume":"14","author":"Mlcek","year":"2021","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"3753","DOI":"10.1093\/eurheartj\/ehaa547","article-title":"Prevention and treatment of pulmonary congestion in patients undergoing venoarterial extracorporeal membrane oxygenation for cardiogenic shock","volume":"41","author":"Orban","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1007\/s00134-011-2358-2","article-title":"Predictors of successful extracorporeal membrane oxygenation (ECMO) weaning after assistance for refractory cardiogenic shock","volume":"37","author":"Aissaoui","year":"2011","journal-title":"Intensiv. Care Med."},{"key":"ref_66","first-page":"e007679","article-title":"Response by Brahmbhatt et al. to Letter Regarding Article, \u201cLiberation From Venoarterial Extracorporeal Membrane Oxygenation: A Review\u201d","volume":"14","author":"Brahmbhatt","year":"2022","journal-title":"Circ. Heart Fail."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/bja\/aew151","article-title":"Beneficial effects of levosimendan on survival in patients undergoing extracorporeal membrane oxygenation after cardiovascular surgery","volume":"117","author":"Distelmaier","year":"2016","journal-title":"Br. J. Anaesth."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1186\/s13054-020-03122-y","article-title":"Can levosimendan reduce ECMO weaning failure in cardiogenic shock?: A cohort study with propensity score analysis","volume":"24","author":"Guilherme","year":"2020","journal-title":"Crit. 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