{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:39:13Z","timestamp":1792802353418,"version":"4.5.0"},"reference-count":35,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This 8-week, multicenter, randomized, active-controlled, observer-blinded clinical trial was designed to demonstrate the accelerating effect on wound healing of the novel Olea europaea leaf extract hydrogel (EHO-85) by comparing it to a widely used amorphous hydrogel. Results showed that EHO-85 significantly accelerated wound healing, regardless of ulcer etiology (pressure, venous leg or diabetic foot) and prognosis, doubling the median wound area reduction compared with a reference amorphous hydrogel (79.4% vs. 39.7%; difference: \u221239.7%, 95% CI: \u221271.1 to \u221221.3%; p &lt; 0.001). The intention-to-treat analysis was conducted on 195 patients from 23 Spanish health centers\/nursing homes. This novel treatment balances the ulcer microenvironment by modulating reactive oxygen species and pH. These actions complement the moistening and barrier functions inherent to amorphous hydrogels, whilst also conferring EHO-85 its documented granulation formation and pain relief properties. Furthermore, efficacy was achieved safely and in a cost-efficient manner due to its multi-dose format, which reduced the amount of product needed by 85.8% over 8 weeks compared to single-use hydrogel. The present randomized controlled trial is a relevant milestone in evidence-based practice for being the first to demonstrate (i) the effectiveness of an amorphous hydrogel in accelerating wound healing and (ii) the superiority of a specific hydrogel over another.<\/jats:p>","DOI":"10.3390\/jcm11051260","type":"journal-article","created":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T20:47:17Z","timestamp":1645994837000},"page":"1260","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Superiority of a Novel Multifunctional Amorphous Hydrogel Containing Olea europaea Leaf Extract (EHO-85) for the Treatment of Skin Ulcers: A Randomized, Active-Controlled Clinical Trial"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8307-7323","authenticated-orcid":false,"given":"Jos\u00e9","family":"Verd\u00fa-Soriano","sequence":"first","affiliation":[{"name":"Department of Community Nursing, Preventive Medicine, Public Health and History of Science, Faculty of Health Sciences, University of Alicante, 03690 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisol","family":"de Cristino-Espinar","sequence":"additional","affiliation":[{"name":"Nursing Department, Reina Sofia University Hospital, 14004 C\u00f3rdoba, Spain"},{"name":"Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sof\u00eda University Hospital, University of C\u00f3rdoba, 14004 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Luna-Morales","sequence":"additional","affiliation":[{"name":"Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sof\u00eda University Hospital, University of C\u00f3rdoba, 14004 C\u00f3rdoba, Spain"},{"name":"Occidente Health Center, C\u00f3rdoba and Guadalquivir Health Management Area, 14005 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caridad","family":"Dios-Guerra","sequence":"additional","affiliation":[{"name":"Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sof\u00eda University Hospital, University of C\u00f3rdoba, 14004 C\u00f3rdoba, Spain"},{"name":"Occidente Health Center, C\u00f3rdoba and Guadalquivir Health Management Area, 14005 C\u00f3rdoba, Spain"},{"name":"Department of Nursing, Faculty of Medicine and Nursing, University of Cordoba, 14004 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0571-5147","authenticated-orcid":false,"given":"Javier","family":"Caballero-Villarraso","sequence":"additional","affiliation":[{"name":"Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sof\u00eda University Hospital, University of C\u00f3rdoba, 14004 C\u00f3rdoba, Spain"},{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine and Nursing, University of Cordoba, 14004 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Moreno-Moreno","sequence":"additional","affiliation":[{"name":"Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sof\u00eda University Hospital, University of C\u00f3rdoba, 14004 C\u00f3rdoba, Spain"},{"name":"Clinical Management Unit of Endocrinology and Nutrition, Reina Sofia University Hospital, 14004 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8520-8278","authenticated-orcid":false,"given":"Antonio","family":"Casado-D\u00edaz","sequence":"additional","affiliation":[{"name":"Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sof\u00eda University Hospital, University of C\u00f3rdoba, 14004 C\u00f3rdoba, Spain"},{"name":"Clinical Management Unit of Endocrinology and Nutrition, Reina Sofia University Hospital, 14004 C\u00f3rdoba, Spain"},{"name":"Consortium for Biomedical Research in Frailty & Healthy Ageing, (CIBERFES), Institute of Health Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Berenguer-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Community Nursing, Preventive Medicine, Public Health and History of Science, Faculty of Health Sciences, University of Alicante, 03690 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ipek","family":"Guler-Caama\u00f1o","sequence":"additional","affiliation":[{"name":"Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sof\u00eda University Hospital, University of C\u00f3rdoba, 14004 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4717-5169","authenticated-orcid":false,"given":"Olga","family":"Laosa-Zafra","sequence":"additional","affiliation":[{"name":"Consortium for Biomedical Research in Frailty & Healthy Ageing, (CIBERFES), Institute of Health Carlos III, 28029 Madrid, Spain"},{"name":"Geriatric Research Group, Biomedical Research Foundation at Getafe University Hospital, 28905 Getafe, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leocadio","family":"Rodr\u00edguez-Ma\u00f1as","sequence":"additional","affiliation":[{"name":"Consortium for Biomedical Research in Frailty & Healthy Ageing, (CIBERFES), Institute of Health Carlos III, 28029 Madrid, Spain"},{"name":"Department of Geriatrics, University Hospital of Getafe, 28905 Getafe, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6110-0265","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"L\u00e1zaro-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Diabetic Foot Unit, University Clinic of Podiatry, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"ref_1","first-page":"S29","article-title":"A Standardized Approach to Evaluating Lower Extremity Chronic Wounds Using a Checklist","volume":"31","author":"Snyder","year":"2019","journal-title":"Wounds"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/iwj.12623","article-title":"Wound management for the 21st century: Combining effectiveness and efficiency","volume":"13","author":"Lindholm","year":"2016","journal-title":"Int. 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