{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:59:06Z","timestamp":1788872346453,"version":"build-2803163510"},"reference-count":36,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T00:00:00Z","timestamp":1645920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Context: The management of acute coronary syndrome (ACS) is based on a rapid diagnosis. The aim of this study was to focus on the ACS symptoms differences according to gender, in order to contribute to the improvement of knowledge regarding the clinical presentation in women. (2) Methods: We searched for relevant literature in two electronic databases, and analyzed the symptom presentation for patients with suspected ACS. Fifteen prospective studies were included, with a total sample size of 10,730. (3) Results: During a suspected ACS, women present more dyspnea, arm pain, nausea and vomiting, fatigue, palpitations and pain at the shoulder than men, with RR (95%CI) of 1.13 [1.10; 1.17], 1.30 [1.05; 1.59], 1,40 [1.26; 1.56], 1.08 [1.01; 1.16], 1.67 [1.49; 1.86], 1.78 [1.02; 3.13], respectively. They are older by (95%CI) 4.15 [2.28; 6.03] years compared to men. The results are consistent in the analysis of the ACS confirmed subgroup. (4) Conclusions: We have shown that there is a gender-based symptomatic difference and a female presentation for ACS. The \u201ctypical\u201d or \u201catypical\u201d semiology of ACS symptoms should no longer be used.<\/jats:p>","DOI":"10.3390\/jcm11051319","type":"journal-article","created":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T20:47:17Z","timestamp":1645994837000},"page":"1319","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Symptoms of Infarction in Women: Is There a Real Difference Compared to Men? A Systematic Review of the Literature with Meta-Analysis"],"prefix":"10.3390","volume":"11","author":[{"given":"Martin","family":"Cardeillac","sequence":"first","affiliation":[{"name":"Emergency Department, Regional Hospital of Metz-Thionville, 57000 Metz, France"},{"name":"Medical School, University of Lorraine, 9 Avenue de la for\u00eat de Haye, Vand\u0153uvre-l\u00e8s-Nancy, 54505 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"Groupe de M\u00e9thodes en Recherche Clinique (GMRC), University Hospital of Strasbourg, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0534-0122","authenticated-orcid":false,"given":"Florent","family":"Baicry","sequence":"additional","affiliation":[{"name":"Emergency Department, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9141-6439","authenticated-orcid":false,"given":"Pierrick","family":"Le Borgne","sequence":"additional","affiliation":[{"name":"Emergency Department, H\u00f4pitaux Universitaires de Strasbourg, 67000 Strasbourg, France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale\u2014Unit\u00e9 Mixte de Recherch\u00e9 (INSERM UMR) 1260, Regenerative NanoMedicine (RNM), F\u00e9d\u00e9ration de M\u00e9decine 63 Translationnelle (FMTS), University of Strasbourg, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5329-6405","authenticated-orcid":false,"given":"C\u00e9dric","family":"Gil-Jardin\u00e9","sequence":"additional","affiliation":[{"name":"Pole of Emergency Medicine, University Hospital of Bordeaux, 33000 Bordeaux, France"},{"name":"Equipe AHEAD (Assessing Health in a Digitalizing Real World-Setting), Bordeaux Population Health Research Center Inserm U1219, Universite de Bordeaux\u2014ISPED, 146 rue L\u00e9o Saignat, 33076 Bordeaux, France"},{"name":"Unit\u00e9 Mixte de Recherche Epid\u00e9miologique et de Surveillance Transport Travail Environnement (TS2-UMRESTTE), Universit\u00e9 Gustave Eiffel, Campus de Lyon, 25 Avenue Fran\u00e7ois Mitterrand, Case 24, 69675 Bron, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauriane","family":"Cipolat","sequence":"additional","affiliation":[{"name":"Emergency Department, Regional Hospital of Metz-Thionville, 57000 Metz, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Peschanski","sequence":"additional","affiliation":[{"name":"Emergency Department, University Hospital of Rennes, 35000 Rennes, France"},{"name":"Rennes-1 University School of Medicine, 35000 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2527-8458","authenticated-orcid":false,"given":"Laure","family":"Abensur Vuillaume","sequence":"additional","affiliation":[{"name":"Emergency Department, Regional Hospital of Metz-Thionville, 57000 Metz, France"},{"name":"International Research Lab 2958 Georgia Tech Institute\u2014Centre National de la Recherche Scientifique (CNRS), 57000 Metz, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,27]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2021, August 04). 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