{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:55:45Z","timestamp":1791892545169,"version":"4.3.4"},"reference-count":37,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Groupe Lipides Nutrition","award":["2017-PC-7225"],"award-info":[{"award-number":["2017-PC-7225"]}]},{"DOI":"10.13039\/501100004099","name":"Ligue contre le cancer","doi-asserted-by":"publisher","award":["2017 APOPROLIF"],"award-info":[{"award-number":["2017 APOPROLIF"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Plasma lipids are carried within lipoproteins with various apolipoprotein content. This study evaluates the interest of measuring the apolipoproteins of circulating lipoproteins in breast cancer. Patients with early-stage breast cancer (n = 140) were included. Tumors differed by the expression of estrogen and progesterone receptor (HR\u2212 and HR+ for negative and positive expression) and the proliferation marker Ki-67 (\u226420% or \u226530%). Apolipoprotein concentrations were determined in plasma, HDL and non-HDL fractions, and results are given in mg\/dL, median (25th\u201375th). Patients did not differ in their plasma and lipoprotein lipid concentrations. HDL apoC-I and non-HDL apoC-II were reduced (1.34 (1.02\u20131.80) vs. 1.61 (1.32\u20132.04), p = 0.04; 0.31 (0.18\u20130.65) vs. 0.63 (0.39\u20131.02), p = 0.01; respectively), in RH-\/high Ki-67 patients in comparison to RH-\/low Ki-67 patients, while plasma apoD and HDL apoD were higher (3.24 (2.99\u20134.16) vs. 3.07 (2.39\u20133.51), p = 0.04; 2.74 (2.36\u20133.35) vs. 2.45 (2.01\u20132.99), p = 0.04; respectively). When RH+\/high Ki-67 patients were compared with RH+\/low Ki-67 patients, HDL apoC-I and HDL apoC-III were higher (1.56 (1.20\u20131.95) vs. 1.35 (1.10\u20131.62), p = 0.02; 2.80 (2.42\u20133.64) vs. 2.38 (1.69\u20132.96), p = 0.02; respectively). The distribution of exchangeable apolipoproteins, such as apoC-I, apoC-II, apoC-III, apoD, between lipoproteins is linked to the severity of breast cancer.<\/jats:p>","DOI":"10.3390\/jcm11051345","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T20:11:14Z","timestamp":1646079074000},"page":"1345","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Circulating HDL and Non-HDL Associated Apolipoproteins and Breast Cancer Severity"],"prefix":"10.3390","volume":"11","author":[{"given":"Christine","family":"Bobin-Dubigeon","sequence":"first","affiliation":[{"name":"CRNHO, West Human Nutrition Research Center, Universit\u00e9 de Nantes, EA 2160-IUML FR3473 CNRS, F-44035 Nantes, France"},{"name":"Institut de Canc\u00e9rologie de l\u2019Ouest, F-44805 Saint-Herblain, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3607-295X","authenticated-orcid":false,"given":"Hassan","family":"Nazih","sequence":"additional","affiliation":[{"name":"CRNHO, West Human Nutrition Research Center, Universit\u00e9 de Nantes, EA 2160-IUML FR3473 CNRS, F-44035 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9970-0530","authenticated-orcid":false,"given":"Valentin","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Department of Medecine, Centre for Heart Lung Innovation, Providence Healthcare Research Institute, St. Paul\u2019s Hospital, University of British Columbia, Vancouver, BC V6Z1Y6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika\u00ebl","family":"Croyal","sequence":"additional","affiliation":[{"name":"CRNHO, West Human Nutrition Research Center, Universit\u00e9 de Nantes, CNRS, INSERM, l\u2019Institut du Thorax, F-44035 Nantes, France"},{"name":"CHU Nantes, Inserm, CNRS, SFR Sant\u00e9, Inserm UMS 016, CNRS UMS 3556, F-44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9123-8123","authenticated-orcid":false,"given":"Jean-Marie","family":"Bard","sequence":"additional","affiliation":[{"name":"CRNHO, West Human Nutrition Research Center, Universit\u00e9 de Nantes, EA 2160-IUML FR3473 CNRS, F-44035 Nantes, France"},{"name":"Institut de Canc\u00e9rologie de l\u2019Ouest, F-44805 Saint-Herblain, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1385\/ENDO:13:2:155","article-title":"Metabolic Complications of Obesity","volume":"13","author":"Grundy","year":"2000","journal-title":"ENDO"},{"key":"ref_2","first-page":"790","article-title":"Obesity and Breast Cancer: Risk, Outcomes, and Future Considerations","volume":"14","author":"Yung","year":"2016","journal-title":"Clin. Adv. Hematol. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nrendo.2014.94","article-title":"Obesity and Cancer--Mechanisms Underlying Tumour Progression and Recurrence","volume":"10","author":"Park","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Ced\u00f3, L., Reddy, S.T., Mato, E., Blanco-Vaca, F., and Escol\u00e0-Gil, J.C. (2019). HDL and LDL: Potential New Players in Breast Cancer Development. J. Clin. Med., 8.","DOI":"10.3390\/jcm8060853"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0076-6879(96)63004-3","article-title":"Significance of Apolipoproteins for Structure, Function, and Classification of Plasma Lipoproteins","volume":"263","author":"Alaupovic","year":"1996","journal-title":"Methods Enzym."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1007\/s12094-020-02354-2","article-title":"Apolipoproteins, as the Carrier Proteins for Lipids, Are Involved in the Development of Breast Cancer","volume":"22","author":"Zhou","year":"2020","journal-title":"Clin. Transl. Oncol."},{"key":"ref_7","first-page":"247","article-title":"Plasma Apolipoprotein A1 Levels at Diagnosis Are Independent Prognostic Factors in Invasive Ductal Breast Cancer","volume":"23","author":"Lin","year":"2017","journal-title":"Discov. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcla.20492","article-title":"Search for Breast Cancer Biomarkers in Fractionated Serum Samples by Protein Profiling With SELDI-TOF MS: Protein Profiling in Fractionated Serum Samples","volume":"26","author":"Beijnen","year":"2012","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/00000658-197703000-00005","article-title":"Evaluation of a Breast Cyst Fluid Protein Detectable in the Plasma of Breast Carcinoma Patients","volume":"185","author":"Haagensen","year":"1977","journal-title":"Ann. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"15959","DOI":"10.1007\/s13277-016-5453-8","article-title":"Serum Levels of Apolipoprotein E Correlates with Disease Progression and Poor Prognosis in Breast Cancer","volume":"37","author":"Xu","year":"2016","journal-title":"Tumour. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4143\/crt.2012.44.2.121","article-title":"Apolipoprotein E (APOE) Polymorphisms and Susceptibility to Breast Cancer: A Meta-Analysis","volume":"44","author":"Saadat","year":"2012","journal-title":"Cancer Res. Treat."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.5334\/ojb.62","article-title":"Centre de Ressources Biologiques-Tumoroth\u00e8que: Bioresources and Associated Clinical Data Dedicated to Translational Research in Oncology at the Institut de Canc\u00e9rologie de l\u2019Ouest, France","volume":"7","author":"Heymann","year":"2020","journal-title":"Open J. Bioresour."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1194\/jlr.D120000835","article-title":"A High-Throughput Mass Spectrometry-Based Assay for Large-Scale Profiling of Circulating Human Apolipoproteins","volume":"61","author":"Blanchard","year":"2020","journal-title":"J. Lipid Res."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Melvin, J.C., Garmo, H., Holmberg, L., Hammar, N., Walldius, G., Jungner, I., Lambe, M., and Van Hemelrijck, M. (2017). Glucose and Lipoprotein Biomarkers and Breast Cancer Severity Using Data from the Swedish AMORIS Cohort. BMC Cancer, 17.","DOI":"10.1186\/s12885-017-3232-6"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.12659\/MSM.896531","article-title":"Identification of Apolipoprotein C-I Peptides as a Potential Biomarker and Its Biological Roles in Breast Cancer","volume":"22","author":"Sun","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1080\/15384047.2016.1156262","article-title":"Diagnostic and Prognostic Significance of Serum Apolipoprotein C-I in Triple-Negative Breast Cancer Based on Mass Spectrometry","volume":"17","author":"Song","year":"2016","journal-title":"Cancer Biol."},{"key":"ref_17","first-page":"1115","article-title":"Additive Stimulatory Action of Glucocorticoids and Androgens on Basal and Estrogen-Repressed Apolipoprotein-D Messenger Ribonucleic Acid Levels and Secretion in Human Breast Cancer Cells","volume":"130","author":"Simard","year":"1992","journal-title":"Endocrinology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1210\/endo-126-6-3223","article-title":"Regulation of Progesterone-Binding Breast Cyst Protein GCDFP-24 Secretion by Estrogens and Androgens in Human Breast Cancer Cells: A New Marker of Steroid Action in Breast Cancer","volume":"126","author":"Simard","year":"1990","journal-title":"Endocrinology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1172\/JCI119309","article-title":"Hyperexpression of Mitogen-Activated Protein Kinase in Human Breast Cancer","volume":"99","author":"Sivaraman","year":"1997","journal-title":"J. Clin. Investig."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1161\/01.ATV.0000100404.05459.39","article-title":"Apolipoprotein D Inhibits Platelet-Derived Growth Factor-BB-Induced Vascular Smooth Muscle Cell Proliferated by Preventing Translocation of Phosphorylated Extracellular Signal Regulated Kinase 1\/2 to the Nucleus","volume":"23","author":"Sarjeant","year":"2003","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1096\/fj.03-0053rev","article-title":"Cyclooxygenase-2 and 5-Lipoxygenase Converging Functions on Cell Proliferation and Tumor Angiogenesis: Implications for Cancer Therapy","volume":"17","author":"Romano","year":"2003","journal-title":"FASEB J."},{"key":"ref_22","first-page":"73","article-title":"5-Lipoxygenase Inhibitors Attenuate Growth of Human Renal Cell Carcinoma and Induce Apoptosis through Arachidonic Acid Pathway","volume":"14","author":"Matsuyama","year":"2005","journal-title":"Oncol. Rep."},{"key":"ref_23","first-page":"285","article-title":"Apolipoprotein D Expression in Metastasic Lymph Nodes of Breast Cancer","volume":"2","author":"Lamelas","year":"2000","journal-title":"Int. J. Surg. Investig."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s10549-006-9310-0","article-title":"Local Recurrence after Mastectomy for Breast Cancer: Analysis of Clinicopathological, Biological and Prognostic Characteristics","volume":"102","author":"Corte","year":"2007","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_25","first-page":"310","article-title":"Expression and Prognostic Significance of Apolipoprotein D in Breast Cancer","volume":"144","author":"Vizoso","year":"1994","journal-title":"Am. J. Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.bbamcr.2007.03.007","article-title":"Modulation of Apolipoprotein D Expression and Translocation under Specific Stress Conditions","volume":"1773","author":"Levros","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1080\/02841860802620613","article-title":"Co-Expression of Estrogen Receptor Alpha and Apolipoprotein D in Node Positive Operable Breast Cancer\u2014Possible Relevance for Survival and Effects of Adjuvant Tamoxifen in Postmenopausal Patients","volume":"48","author":"Skaland","year":"2009","journal-title":"Acta Oncol."},{"key":"ref_28","first-page":"2105","article-title":"Progesterone Binding Cyst Protein in Hormone Receptor Positive Breast Cancer; a Predictive Factor for Effect of Adjuvant Tamoxifen Treatment","volume":"14","author":"Kolnes","year":"1994","journal-title":"Anticancer Res."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Klebaner, D., Hamilton-Dutoit, S., Ahern, T., Crawford, A., Jakobsen, T., Cronin-Fenton, D.P., Damkier, P., Janssen, E., Kjaersgaard, A., and Ording, A.G. (2017). Apolipoprotein D Expression Does Not Predict Breast Cancer Recurrence among Tamoxifen-Treated Patients. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0171453"},{"key":"ref_30","first-page":"6189","article-title":"Progesterone-Binding Cyst Protein in Human Breast Tumor Cytosol","volume":"47","author":"Lea","year":"1987","journal-title":"Cancer Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1002\/jcb.24054","article-title":"The Inhibition of Hyaluronan Degradation Reduced Pro-Inflammatory Cytokines in Mouse Synovial Fibroblasts Subjected to Collagen-Induced Arthritis","volume":"113","author":"Campo","year":"2012","journal-title":"J. Cell. Biochem."},{"key":"ref_32","first-page":"3783","article-title":"Macrophage Apolipoprotein E and Proliferation of MCF-7 Breast Cancer Cells: Role of LXR","volume":"33","author":"Bard","year":"2013","journal-title":"Anticancer Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1023\/A:1006464409137","article-title":"Apolipoprotein E Polymorphism and Breast Carcinoma: Correlation with Cell Proliferation Indices and Clinical Outcome","volume":"63","author":"Zunarelli","year":"2000","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/(SICI)1098-2744(200001)27:1<2::AID-MC2>3.0.CO;2-W","article-title":"Apolipoprotein E Genetic Polymorphism, Serum Lipoproteins, and Breast Cancer Risk","volume":"27","author":"Moysich","year":"2000","journal-title":"Mol. Carcinog."},{"key":"ref_35","first-page":"43","article-title":"Apolipoprotein E Allelic Frequency Altered in Women with Early-Onset Breast Cancer","volume":"4","author":"Matta","year":"2010","journal-title":"Breast Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0021-9150(95)05681-5","article-title":"Apolipoprotein E Polymorphism in Middle-Aged Belgian Men: Phenotype Distribution and Relation to Serum Lipids and Lipoproteins","volume":"120","author":"Braeckman","year":"1996","journal-title":"Atherosclerosis"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1161\/01.ATV.9.3.405","article-title":"Differential Distribution of Apolipoprotein E Isoforms in Human Plasma Lipoproteins","volume":"9","author":"Steinmetz","year":"1989","journal-title":"Arteriosclerosis"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/5\/1345\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:29:36Z","timestamp":1760135376000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/5\/1345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,28]]},"references-count":37,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["jcm11051345"],"URL":"https:\/\/doi.org\/10.3390\/jcm11051345","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,28]]}}}