{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:07:00Z","timestamp":1790730420020,"version":"4.1.0"},"reference-count":35,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>We retrospectively evaluated the long-term surgical outcomes of phacoemulsification combined with a Kahook dual blade (KDB) procedure in Japanese patients with open-angle glaucoma. The primary outcome was surgical success or failure. Surgical failure was indicated by a &lt;20% reduction in preoperative intraocular pressure (IOP) or IOP &gt; 18 mmHg (criterion A), IOP &gt; 14 mmHg (criterion B), or requirement for reoperation. Glaucoma medications after surgery and postoperative complications were recorded. Surgical outcomes were compared between primary open-angle glaucoma (POAG) and exfoliation glaucoma (ExG) groups. The probability of success at 36 months postoperation was 52.5% using criterion A and 36.9% using criterion B. Mean IOP decreased significantly from 19.5 \u00b1 6.9 mmHg preoperatively to 11.9 \u00b1 2.7 mmHg at 36 months, and the mean number of glaucoma medications from 2.4 \u00b1 1.4 to 1.6 \u00b1 1.4 (both p &lt; 0.01). IOP spikes were significantly more common in the ExG group (23.7% vs. 9.1%; p = 0.045), as was the need for additional glaucoma surgery (10.5% vs. 1.8%; p = 0.038). A KDB procedure combined with cataract surgery resulted in significant long-term decreases in IOP and the number of glaucoma medications. The complication rate was higher in eyes with ExG. Therefore, these eyes require more careful management after a KDB procedure.<\/jats:p>","DOI":"10.3390\/jcm11051354","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T08:17:03Z","timestamp":1646122623000},"page":"1354","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Long-Term Outcomes of a Kahook Dual Blade Procedure Combined with Phacoemulsification in Japanese Patients with Open-Angle Glaucoma"],"prefix":"10.3390","volume":"11","author":[{"given":"Kentaro","family":"Iwasaki","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kakimoto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Obama Hospital, Fukui 917-0078, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Orii","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Arimura","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Takamura","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0896-996X","authenticated-orcid":false,"given":"Masaru","family":"Inatani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan"},{"name":"Department of Ophthalmology, Obama Hospital, Fukui 917-0078, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1001\/archopht.1993.01090120075025","article-title":"Surgical effects of trabeculotomy ab externo on adult eyes with primary open angle glaucoma and pseudoexfoliation syndrome","volume":"111","author":"Tanihara","year":"1993","journal-title":"Arch. Ophthalmol."},{"key":"ref_2","first-page":"735","article-title":"Trabeculotomy ab externo: An alternative treatment in adult patients with primary open-angle glaucoma","volume":"24","author":"Chihara","year":"1993","journal-title":"Ophthalmic. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.ajo.2010.11.028","article-title":"Success rates of trabeculotomy for steroid-induced glaucoma: A comparative, multicenter, retrospective cohort study","volume":"151","author":"Iwao","year":"2011","journal-title":"Am. J. Ophthalmol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1001\/archopht.122.8.1122","article-title":"Long-term outcome of trabeculotomy for the treatment of developmental glaucoma","volume":"122","author":"Ikeda","year":"2004","journal-title":"Arch. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0886-3350(96)80017-4","article-title":"Trabeculotomy ab externo, cataract extraction, and intraocular lens implantation: Preliminary report","volume":"22","author":"Honjo","year":"1996","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/00061198-200108000-00010","article-title":"Surgical outcome of combined trabeculotomy and cataract surgery","volume":"10","author":"Tanito","year":"2001","journal-title":"J. Glaucoma"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0002-9394(98)00045-2","article-title":"Local effects of previous conjunctival incisional surgery and the subsequent outcome of filtration surgery","volume":"125","author":"Broadway","year":"1998","journal-title":"Am. J. Ophthalmol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/00061198-200106000-00017","article-title":"Trabeculectomy, risk factors for failure and the preoperative state of the conjunctiva","volume":"10","author":"Broadway","year":"2001","journal-title":"J. Glaucoma."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s00417-009-1051-4","article-title":"Restricted post-trabeculectomy bleb formation by conjunctival scarring","volume":"247","author":"Iwao","year":"2009","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s10384-020-00749-w","article-title":"Clinical practice preferences for glaucoma surgery in Japan: A survey of Japan Glaucoma Society specialists","volume":"64","author":"Iwasaki","year":"2020","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref_11","first-page":"189","article-title":"Minimally invasive glaucoma surgery: Current status and future prospects","volume":"10","author":"Richter","year":"2016","journal-title":"Clin. Ophthalmol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/ICU.0000000000000457","article-title":"Complications of micro-invasive glaucoma surgery","volume":"29","author":"Yook","year":"2018","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2147\/OPTH.S239772","article-title":"Prospective studies of minimally invasive glaucoma surgeries: Systematic review and quality assessment","volume":"14","author":"Rosdahl","year":"2020","journal-title":"Clin. Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.ajo.2012.09.023","article-title":"Preclinical investigation of ab interno trabeculectomy using a novel dual-blade device","volume":"155","author":"Seibold","year":"2013","journal-title":"Am. J. Ophthalmol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"941","DOI":"10.18240\/ijo.2020.06.13","article-title":"Performances of glaucoma operations with Kahook Dual Blade or iStent combined with phacoemulsification in Japanese open angle glaucoma patients","volume":"13","author":"Iwasaki","year":"2020","journal-title":"Int. J. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.jcrs.2017.06.046","article-title":"Goniotomy with a single-use dual blade: Short-term results","volume":"43","author":"Greenwood","year":"2017","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1007\/s12325-018-0755-4","article-title":"12-month outcomes of goniotomy performed using the kahook dual blade combined with cataract surgery in eyes with medically treated glaucoma","volume":"35","author":"Dorairaj","year":"2018","journal-title":"Adv. Ther."},{"key":"ref_18","first-page":"707","article-title":"Outcome of phacoemulsification combined with excisional goniotomy using the Kahook Dual Blade in severe glaucoma patients at 6 months","volume":"13","author":"Hirabayashi","year":"2019","journal-title":"Clin. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Ansari, E., and Loganathan, D. (2021). 12-month clinical outcomes of combined phacoemulsification and ab interno trabeculectomy for open-angle glaucoma in the United Kingdom. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0252826"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"791","DOI":"10.2147\/OPTH.S158403","article-title":"A multicenter retrospective comparison of goniotomy versus trabecular bypass device implantation in glaucoma patients undergoing cataract extraction","volume":"12","author":"Dorairaj","year":"2018","journal-title":"Clin. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1007\/s12325-019-01025-1","article-title":"12-month retrospective comparison of Kahook Dual Blade excisional goniotomy with istent trabecular bypass device implantation in glaucomatous eyes at the time of cataract surgery","volume":"36","author":"ElMallah","year":"2019","journal-title":"Adv. Ther."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1097\/j.jcrs.0000000000000229","article-title":"Excisional goniotomy vs trabecular microbypass stent implantation: A prospective randomized clinical trial in eyes with mild to moderate open-angle glaucoma","volume":"46","author":"Falkenberry","year":"2020","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"10660","DOI":"10.1038\/s41598-021-90223-5","article-title":"Long term outcome of combined phacoemulsification and excisional goniotomy with the Kahook Dual Blade in different subtypes of glaucoma","volume":"11","author":"Albuainain","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Omoto, T., Sugiura, A., Fujishiro, T., Asano-Shimizu, K., Sugimoto, K., Sakata, R., Murata, H., Asaoka, R., Honjo, M., and Aihara, M. (2021). Twelve-month surgical outcome and prognostic factors of stand-alone ab interno trabeculotomy in Japanese patients with open-angle glaucoma. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0245015"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1097\/j.jcrs.0000000000000263","article-title":"Efficacy and safety of a single-use dual blade goniotomy: 18-month results","volume":"46","author":"Wakil","year":"2020","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.ajo.2008.11.015","article-title":"Trabeculectomy with mitomycin C for neovascular glaucoma: Prognostic factors for surgical failure","volume":"147","author":"Takihara","year":"2009","journal-title":"Am. J. Ophthalmol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ogla.2018.06.006","article-title":"Outcomes of Kahook Dual Blade goniotomy with and without phacoemulsification cataract extraction","volume":"1","author":"Sieck","year":"2018","journal-title":"Ophthalmol. Glaucoma"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1097\/IJG.0000000000001019","article-title":"Goniotomy using the Kahook Dual Blade in severe and refractory glaucoma: 6-month outcomes","volume":"27","author":"Salinas","year":"2018","journal-title":"J. Glaucoma"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/j.jcrs.0000000000000397","article-title":"Outcomes of cataract surgery in pseudoexfoliation syndrome in England: 10-year retrospective cohort study","volume":"47","author":"Ong","year":"2021","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S1350-9462(99)00019-1","article-title":"Exfoliation syndrome and exfoliation glaucoma","volume":"19","author":"Vesti","year":"2000","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.ajo.2009.03.024","article-title":"Increased likelihood of glaucoma at the same screening intraocular pressure in subjects with pseudoexfoliation: The Thessaloniki Eye Study","volume":"148","author":"Topouzis","year":"2009","journal-title":"Am. J. Ophthalmol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ophtha.2011.06.046","article-title":"Ab interno trabeculectomy versus trabeculectomy for open-angle glaucoma","volume":"119","author":"Jea","year":"2012","journal-title":"Ophthalmology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s10384-020-00781-w","article-title":"Effectiveness and limitations of minimally invasive glaucoma surgery targeting Schlemm\u2019s canal","volume":"65","author":"Kasahara","year":"2021","journal-title":"Jpn. J. Ophthalmol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.jcrs.2012.04.028","article-title":"Simultaneous increases in multiple proinflammatory cytokines in the aqueous humor in pseudophakic glaucomatous eyes","volume":"38","author":"Inoue","year":"2012","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1001\/archopht.122.6.838","article-title":"Goniosurgery for glaucoma complicating chronic childhood uveitis","volume":"122","author":"Ho","year":"2004","journal-title":"Arch. Ophthalmol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/5\/1354\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:30:07Z","timestamp":1760135407000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/5\/1354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":35,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["jcm11051354"],"URL":"https:\/\/doi.org\/10.3390\/jcm11051354","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,1]]}}}