{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:07:15Z","timestamp":1792789635731,"version":"4.5.0"},"reference-count":59,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Appel d\u2019Offre Interne (AOI) of the CHU Nantes.","award":["AOI-CHUN-2015-CO"],"award-info":[{"award-number":["AOI-CHUN-2015-CO"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The benefits of parathyroidectomy on cardiovascular risk in primary hyperparathyroidism (PHPT) are controversial. This monocentric, observational, prospective study aimed to assess the effects of parathyroidectomy on glucose and lipid metabolism in classic or mild PHPT. Methods: Patients who underwent parathyroidectomy for classic (calcemia &gt;2.85 mmol\/L) or mild PHPT (calcemia \u22642.85 mmol\/L) between 2016 and 2019 were included. A metabolic assessment was performed before and 1 year after parathyroidectomy. Patients with a history of diabetes were excluded. Results: Nineteen patients had classic and 120 had mild PHPT. Ninety-five percent were normocalcemic 6 months after surgery. Fasting plasma glucose and insulin levels decreased after parathyroidectomy in patients with mild PHPT (p &lt; 0.001). HOMA-IR decreased after surgery in the overall population (p &lt; 0.001), while plasma adiponectin concentrations increased in patients with both classic (p = 0.005) and mild PHPT (p &lt; 0.001). Plasma triglyceride levels decreased significantly only in patients with classic PHPT (p = 0.021). Plasma PCSK9 levels decreased in patients with mild PHPT (p &lt; 0.001). Conclusions: Parathyroidectomy for PHPT improves insulin resistance and decreases plasma triglyceride levels in classic PHPT and plasma PCSK9 levels in mild PHPT. Further studies are needed to better characterize the consequences of such metabolic risk factors\u2019 improvements on cardiovascular events.<\/jats:p>","DOI":"10.3390\/jcm11051373","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T08:37:16Z","timestamp":1646210236000},"page":"1373","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effect of Parathyroidectomy on Metabolic Homeostasis in Primary Hyperparathyroidism"],"prefix":"10.3390","volume":"11","author":[{"given":"Samuel","family":"Frey","sequence":"first","affiliation":[{"name":"Chirurgie Canc\u00e9rologique, Digestive et Endocrinienne, Institut des Maladies de l\u2019Appareil Digestif, CHU de Nantes, 44000 Nantes, France"},{"name":"Universit\u00e9 de Nantes, Quai de Tourville, 44000 Nantes, France"},{"name":"L\u2019Institut du Thorax, UNIV NANTES, CNRS, INSERM, CHU de Nantes, 44007 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Bourgade","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Nantes, Quai de Tourville, 44000 Nantes, France"},{"name":"CHU de Nantes, INSERM, CIC 1413, P\u00f4le Hospitalo-Universitaire 11: Sant\u00e9 Publique, Sant\u00e9 au Travail, Pharmacie, St\u00e9rilisation, Clinique des Donn\u00e9es, 92130 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7554-792X","authenticated-orcid":false,"given":"C\u00e9dric","family":"Le May","sequence":"additional","affiliation":[{"name":"L\u2019Institut du Thorax, UNIV NANTES, CNRS, INSERM, CHU de Nantes, 44007 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika\u00ebl","family":"Croyal","sequence":"additional","affiliation":[{"name":"L\u2019Institut du Thorax, UNIV NANTES, CNRS, INSERM, CHU de Nantes, 44007 Nantes, France"},{"name":"Universit\u00e9 de Nantes, CHU Nantes, Inserm, CNRS, SFR Sant\u00e9, Inserm UMS 016, CNRS UMS 3556, 44000 Nantes, France"},{"name":"CRNH-Ouest Mass Spectrometry Core Facility, 44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Bigot-Corbel","sequence":"additional","affiliation":[{"name":"Laboratoire de Biochimie, Centre Hospitalier Universitaire de Nantes, H\u00f4pital Guillaume et Ren\u00e9 La\u00ebnnec, 44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Renaud-Moreau","sequence":"additional","affiliation":[{"name":"Chirurgie Canc\u00e9rologique, Digestive et Endocrinienne, Institut des Maladies de l\u2019Appareil Digestif, CHU de Nantes, 44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Wargny","sequence":"additional","affiliation":[{"name":"L\u2019Institut du Thorax, UNIV NANTES, CNRS, INSERM, CHU de Nantes, 44007 Nantes, France"},{"name":"CHU de Nantes, INSERM, CIC 1413, P\u00f4le Hospitalo-Universitaire 11: Sant\u00e9 Publique, Sant\u00e9 au Travail, Pharmacie, St\u00e9rilisation, Clinique des Donn\u00e9es, 92130 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Caillard","sequence":"additional","affiliation":[{"name":"Chirurgie Canc\u00e9rologique, Digestive et Endocrinienne, Institut des Maladies de l\u2019Appareil Digestif, CHU de Nantes, 44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Miralli\u00e9","sequence":"additional","affiliation":[{"name":"Chirurgie Canc\u00e9rologique, Digestive et Endocrinienne, Institut des Maladies de l\u2019Appareil Digestif, CHU de Nantes, 44000 Nantes, France"},{"name":"Universit\u00e9 de Nantes, Quai de Tourville, 44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1580-8040","authenticated-orcid":false,"given":"Bertrand","family":"Cariou","sequence":"additional","affiliation":[{"name":"L\u2019Institut du Thorax, UNIV NANTES, CNRS, INSERM, CHU de Nantes, 44007 Nantes, France"},{"name":"Service d\u2019Endocrinologie, Diab\u00e9tologie et Nutrition, l\u2019Institut du Thorax, CHU de Nantes, 44093 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Blanchard","sequence":"additional","affiliation":[{"name":"Chirurgie Canc\u00e9rologique, Digestive et Endocrinienne, Institut des Maladies de l\u2019Appareil Digestif, CHU de Nantes, 44000 Nantes, France"},{"name":"Universit\u00e9 de Nantes, Quai de Tourville, 44000 Nantes, France"},{"name":"L\u2019Institut du Thorax, UNIV NANTES, CNRS, INSERM, CHU de Nantes, 44007 Nantes, 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