{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:21:14Z","timestamp":1790115674754,"version":"4.0.1"},"reference-count":22,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["LY20H120009"],"award-info":[{"award-number":["LY20H120009"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31751003, 82171013"],"award-info":[{"award-number":["31751003, 82171013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008856","name":"Health Commission of Zhejiang Province","doi-asserted-by":"publisher","award":["2022KY168"],"award-info":[{"award-number":["2022KY168"]}],"id":[{"id":"10.13039\/501100008856","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Bethune Charitable Foundation","award":["BJ-GY2021013J"],"award-info":[{"award-number":["BJ-GY2021013J"]}]},{"DOI":"10.13039\/501100017599","name":"Major Science and Technology Projects of Zhejiang Province","doi-asserted-by":"publisher","award":["2022C03173"],"award-info":[{"award-number":["2022C03173"]}],"id":[{"id":"10.13039\/501100017599","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This prospective randomized study evaluated the efficacy and safety of intense pulsed light (IPL) and meibomian gland expression (MGX) as polytherapy for Sj\u00f6gren\u2019s Syndrome-related dry eye (SS-DE). The study enrolled 55 participants with SS-DE, 27 for the treatment group and 28 for the control group. The treatment group underwent three IPL-MGX treatments, three weeks apart. A randomly-selected eye from each patient was assessed at baseline and on weeks 9, 12, and 15 for Snellen best-corrected visual acuity (BCVA), intraocular pressure, Ocular Surface Disease Index (OSDI) score, conjunctival congestion, tear meniscus height, non-invasive tear breakup time (NBUT), Schirmer\u2019s I test (SIT), corneal fluorescein staining (CFS), meibomian gland (MG) dropout, eyelid margin abnormality, MGX and meibum quality. OSDI, NBUT, CFS, MGX, and meibum quality were significantly improved in both groups, particularly in the treatment group. The eyelid margin abnormality improved significantly in the treatment but not in the control group on weeks 12 and 15. Snellen BCVA, conjunctival congestion, and SIT improved significantly in the treatment group, but the two groups were statistically similar. Our results indicated that three IPL-MGX sessions could significantly improve the subjective and objective characteristics of SS-DE, representing a promising treatment strategy.<\/jats:p>","DOI":"10.3390\/jcm11051377","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T08:37:16Z","timestamp":1646210236000},"page":"1377","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Therapeutic Effect of Intense Pulsed Light in Patients with Sj\u00f6gren\u2019s Syndrome Related Dry Eye"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8185-4387","authenticated-orcid":false,"given":"Yanan","family":"Huo","sequence":"first","affiliation":[{"name":"Eye Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wan","sequence":"additional","affiliation":[{"name":"Eye Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China"},{"name":"Second Clinical Medical School, Zhejiang Chinese Medical University, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinzhu","family":"Hou","sequence":"additional","affiliation":[{"name":"Second Clinical Medical School, Zhejiang Chinese Medical University, Hangzhou 310053, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Eye Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Zhejiang Institute of Medical Device Supervision and Testing, Hangzhou 310018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Wu","sequence":"additional","affiliation":[{"name":"Eye Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuming","family":"Jin","sequence":"additional","affiliation":[{"name":"Eye Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/clin.1994.1123","article-title":"Sjogren\u2019s syndrome: Autoimmune epithelitis","volume":"72","author":"Moutsopoulos","year":"1994","journal-title":"Clin. 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