{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:08:39Z","timestamp":1791385719986,"version":"4.3.3"},"reference-count":37,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>3D coronary angiography-based vessel fractional flow reserve (vFFR) proved to be an accurate diagnostic alternative to invasively measured pressure wire based fractional flow reserve (FFR). The ability to compute post-PCI vFFR using pre-PCI vFFR virtual stent analysis is unknown. We aimed to assess the feasibility and diagnostic accuracy of pre-PCI vFFR virtual stenting analysis (residual vFFR) with post-PCI FFR as a reference. This is an observational, single-center retrospective cohort study including consecutive patients from the FFR-SEARCH registry. We blindly calculated residual vFFR from pre-PCI angiograms and compared them to invasive pressure-wire based post-PCI FFR. Inclusion criteria involved presentation with either stable or unstable angina or non-ST elevation myocardial infarction (NSTEMI), \u22651 significant stenosis in one of the epicardial coronary arteries (percentage diameter stenosis of &gt;70% by QCA or hemodynamically relevant stenosis with FFR \u22640.80) and pre procedural angiograms eligible for vFFR analysis. Exclusion criteria comprised patients with ST elevation myocardial infarction (STEMI), coronary bypass grafts, cardiogenic shock or severe hemodynamic instability. Eighty-one pre-PCI residual vFFR measurements were compared to post-PCI FFR and post-PCI vFFR measurements. Mean residual vFFR was 0.91 \u00b1 0.06, mean post-PCI FFR 0.91 \u00b1 0.06 and mean post-PCI vFFR was 0.92 \u00b1 0.05. Residual vFFR showed a high linear correlation (r = 0.84) and good agreement (mean difference (95% confidence interval): 0.005 (\u22120.002\u20130.012)) with post-PCI FFR, as well as with post-PCI-vFFR (r = 0.77, mean difference \u22120.007 (\u22120.015\u20130.0003)). Residual vFFR showed good accuracy in the identification of lesions with post-PCI FFR &lt; 0.90 (sensitivity 94%, specificity 71%, area under the curve (AUC) 0.93 (95% CI: 0.86\u20130.99), p &lt; 0.001). Virtual stenting using vFFR provided an accurate estimation of post-PCI FFR and post-PCI vFFR. Further studies are needed to prospectively validate a vFFR-guided PCI strategy.<\/jats:p>","DOI":"10.3390\/jcm11051397","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T09:24:53Z","timestamp":1646299493000},"page":"1397","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Diagnostic Accuracy of Coronary Angiography-Based Vessel Fractional Flow Reserve (vFFR) Virtual Stenting"],"prefix":"10.3390","volume":"11","author":[{"given":"Mariusz","family":"Tomaniak","sequence":"first","affiliation":[{"name":"Department of Cardiology, Erasmus University Medical Center, ThoraxCenter, 3000 CA Rotterdam, The Netherlands"},{"name":"First Department of Cardiology, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Neleman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus University Medical Center, ThoraxCenter, 3000 CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anniek","family":"Ziedses des Plantes","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus University Medical Center, ThoraxCenter, 3000 CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaneshka","family":"Masdjedi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus University Medical Center, ThoraxCenter, 3000 CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurens J. C.","family":"van Zandvoort","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus University Medical Center, ThoraxCenter, 3000 CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz","family":"Kochman","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wijnand K.","family":"den Dekker","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus University Medical Center, ThoraxCenter, 3000 CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen M.","family":"Wilschut","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus University Medical Center, ThoraxCenter, 3000 CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Diletti","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus University Medical Center, ThoraxCenter, 3000 CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Kardys","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus University Medical Center, ThoraxCenter, 3000 CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Zijlstra","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus University Medical Center, ThoraxCenter, 3000 CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas M.","family":"Van Mieghem","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus University Medical Center, ThoraxCenter, 3000 CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"Daemen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus University Medical Center, ThoraxCenter, 3000 CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1056\/NEJMoa1803538","article-title":"Five-year outcomes with PCI Guided by fractional flow reserve","volume":"379","author":"Xaplanteris","year":"2018","journal-title":"N. 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