{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:55:39Z","timestamp":1760151339163,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Research Foundation of Jiangxi Province","award":["20203BBG73059","20181BBG70004"],"award-info":[{"award-number":["20203BBG73059","20181BBG70004"]}]},{"name":"Excellent Talents Development Project of jiangxi Province","award":["20192BCBL23020"],"award-info":[{"award-number":["20192BCBL23020"]}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of jiangxi Province","doi-asserted-by":"publisher","award":["20181BAB205034"],"award-info":[{"award-number":["20181BAB205034"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Grassroots Health Appropriate Technology \u201cSpark Promotion Plan\u201d Project of Jiangxi Province","award":["20188003"],"award-info":[{"award-number":["20188003"]}]},{"name":"Health Development Planning Commission Science Foundation of Jiangxi Province","award":["20201032"],"award-info":[{"award-number":["20201032"]}]},{"name":"Health Development Planning Commission Science TCM Foundation of Jiangxi Province","award":["2018A060"],"award-info":[{"award-number":["2018A060"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Numerous anterior neuroimaging researches have revealed that corneal ulcers (CU) are related to changes in cerebral anatomic structure and functional area. Nonetheless, functional characteristics of the brain\u2019s network organization still show no definite research results. The study was designed to confirm CU-associated spatial centrality distribution functional network of the whole cerebrum and explore the mechanism through which the larvaceous changed the intrinsic functional hubs. Material and Methods: In this study, 40 patients with CU and 40 normal controls (matched in sex, age, and education level) were enrolled in this study to undergo resting-state functional magnetic resonance imaging (fMRI) scans. The differences between the groups were determined by measuring the voxel-wise degree centrality (DC) throughout the whole cerebrum. For the purpose of assessing the correlation between abnormal DC value and clinical variables, the Linear correlation analysis was used. Results: Compared with normal controls (NCs), CU patients revealed high DC values in the frontal lobe, precuneus, inferior parietal lobule, posterior cingulate, occipital lobe, and temporal lobe in the brain functional connectivity maps throughout the brain. The intergroup differences also had high similarity on account of different thresholds. In addition, DC values were positively related to the duration of CU in the left middle frontal gyrus. Conclusions: The experimental results revealed that patients with CU showed spatially unnatural intrinsic functional hubs whether DC values increased or decreased. This brings us to a new level of comprehending the functional features of CU and may offer useful information to make us obtain a clear understanding of the dysfunction of CU.<\/jats:p>","DOI":"10.3390\/jcm11061478","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T12:35:37Z","timestamp":1646742937000},"page":"1478","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Abnormal Intrinsic Functional Hubs in Corneal Ulcer: Evidence from a Voxel-Wise Degree Centrality Analysis"],"prefix":"10.3390","volume":"11","author":[{"given":"Min-Jie","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Center of National Ocular Disease Clinical Research Center, Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Center of National Ocular Disease Clinical Research Center, Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong-Bin","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Center of National Ocular Disease Clinical Research Center, Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Cong","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Center of National Ocular Disease Clinical Research Center, Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Ye","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Center of National Ocular Disease Clinical Research Center, Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2800-9838","authenticated-orcid":false,"given":"Xu-Lin","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Center of National Ocular Disease Clinical Research Center, Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"San-Hua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Center of National Ocular Disease Clinical Research Center, Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Center of National Ocular Disease Clinical Research Center, Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Center of National Ocular Disease Clinical Research Center, Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Juan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Center of National Ocular Disease Clinical Research Center, Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5403-3295","authenticated-orcid":false,"given":"Qian-Min","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Center of National Ocular Disease Clinical Research Center, Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1571-2433","authenticated-orcid":false,"given":"Yi","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Center of National Ocular Disease Clinical Research Center, Nanchang 330006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,8]]},"reference":[{"key":"ref_1","first-page":"214","article-title":"Corneal blindness: A global perspective","volume":"79","author":"Whitcher","year":"2001","journal-title":"Bull. 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