{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:27:20Z","timestamp":1789471640008,"version":"build-2803163510"},"reference-count":67,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T00:00:00Z","timestamp":1647129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Although hypothermia has shown to protect against ischemic and traumatic neuronal death, its potential role in neurologic recovery following traumatic spinal cord injury (TSCI) remains incompletely understood. Herein, we systematically review the safety and efficacy of hypothermia therapy for TSCI. The English medical literature was reviewed using PRISMA guidelines to identify preclinical and clinical studies examining the safety and efficacy of hypothermia following TSCI. Fifty-seven articles met full-text review criteria, of which twenty-eight were included. The main outcomes of interest were neurological recovery and postoperative complications. Among the 24 preclinical studies, both systemic and local hypothermia significantly improved neurologic recovery. In aggregate, the 4 clinical studies enrolled 60 patients for treatment, with 35 receiving systemic hypothermia and 25 local hypothermia. The most frequent complications were respiratory in nature. No patients suffered neurologic deterioration because of hypothermia treatment. Rates of American Spinal Injury Association (AIS) grade conversion after systemic hypothermia (35.5%) were higher when compared to multiple SCI database control studies (26.1%). However, no statistical conclusions could be drawn regarding the efficacy of hypothermia in humans. These limited clinical trials show promise and suggest therapeutic hypothermia to be safe in TSCI patients, though its effect on neurological recovery remains unclear. The preclinical literature supports the efficacy of hypothermia after TSCI. Further clinical trials are warranted to conclusively determine the effects of hypothermia on neurological recovery as well as the ideal means of administration necessary for achieving efficacy in TSCI.<\/jats:p>","DOI":"10.3390\/jcm11061585","type":"journal-article","created":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T22:29:43Z","timestamp":1647210583000},"page":"1585","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Hypothermia Therapy for Traumatic Spinal Cord Injury: An Updated Review"],"prefix":"10.3390","volume":"11","author":[{"given":"Seth C.","family":"Ransom","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Mayo Clinic, Rochester, MN 55902, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6025-346X","authenticated-orcid":false,"given":"Nolan J.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, Irvine, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8012-860X","authenticated-orcid":false,"given":"Zachary A.","family":"Pennington","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Mayo Clinic, Rochester, MN 55902, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Lakomkin","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Mayo Clinic, Rochester, MN 55902, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony L.","family":"Mikula","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Mayo Clinic, Rochester, MN 55902, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Bydon","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Mayo Clinic, Rochester, MN 55902, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"Elder","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Mayo Clinic, Rochester, MN 55902, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,13]]},"reference":[{"key":"ref_1","unstructured":"National Spinal Cord Injury Statistical Center (2020). Facts and Figures at a Glance, University of Alabama at Birmingham."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.wneu.2015.09.079","article-title":"The Role of Therapeutic Hypothermia After Traumatic Spinal Cord Injury\u2014A Systematic Review","volume":"86","author":"Alkabie","year":"2016","journal-title":"World Neurosurg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1001\/jama.2015.6250","article-title":"Traumatic Spinal Cord Injury in the United States, 1993\u20132012","volume":"313","author":"Jain","year":"2015","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0140-6736(02)07603-1","article-title":"Spinal-cord injury","volume":"359","author":"McDonald","year":"2002","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3171\/jns.1973.39.1.0052","article-title":"Value of normothermic perfusion, hypothermic perfusion, and durotomy in the treatment of experimental acute spinal cord trauma","volume":"39","author":"Tator","year":"1973","journal-title":"J. Neurosurg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1089\/089771504323004575","article-title":"The Pathology of Human Spinal Cord Injury: Defining the Problems","volume":"21","author":"Norenberg","year":"2004","journal-title":"J. Neurotrauma"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1750-1326-7-6","article-title":"Spinal cord trauma and the molecular point of no return","volume":"7","author":"Yip","year":"2012","journal-title":"Mol. Neurodegener."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1093\/neuros\/nyw080","article-title":"Traumatic Spinal Cord Injury\u2014Repair and Regeneration","volume":"80","author":"Ahuja","year":"2017","journal-title":"Neurosurgery"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.wneu.2013.01.008","article-title":"Hypothermia for Acute Spinal Cord Injury\u2014A Review","volume":"82","author":"Ahmad","year":"2014","journal-title":"World Neurosurg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1007\/s11999-016-5133-4","article-title":"Classifications in Brief: American Spinal Injury Association (ASIA) Impairment Scale","volume":"475","author":"Roberts","year":"2017","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/sc.2010.99","article-title":"Extent of spontaneous motor recovery after traumatic cervical sensorimotor complete spinal cord injury","volume":"49","author":"Steeves","year":"2011","journal-title":"Spinal Cord"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"E57","DOI":"10.1097\/BRS.0b013e3181b9dc28","article-title":"The Use of Systemic Hypothermia for the Treatment of an Acute Cervical Spinal Cord Injury in a Professional Football Player","volume":"35","author":"Cappuccino","year":"2010","journal-title":"Spine"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.spinee.2007.12.006","article-title":"Hypothermia for spinal cord injury","volume":"8","author":"Kwon","year":"2008","journal-title":"Spine J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1503\/cmaj.051578","article-title":"Stock your emergency department with ice packs: A practical guide to therapeutic hypothermia for survivors of cardiac arrest","volume":"176","author":"Green","year":"2007","journal-title":"Can. Med. Assoc. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.resuscitation.2006.08.023","article-title":"Cold infusions alone are effective for induction of therapeutic hypothermia but do not keep patients cool after cardiac arrest","volume":"73","author":"Kliegel","year":"2007","journal-title":"Resuscitation"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1227\/01.NEU.0000129683.99430.8C","article-title":"Comparison of Endovascular and Surface Cooling during Unruptured Cerebral Aneurysm Repair","volume":"55","author":"Steinberg","year":"2004","journal-title":"Neurosurgery"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1097\/01.CCM.0000148087.41418.0A","article-title":"Keeping a cool head: How to induce and maintain hypothermia","volume":"32","author":"Polderman","year":"2004","journal-title":"Crit. Care Med."},{"key":"ref_18","first-page":"S497","article-title":"Hypothermia in spinal cord injury","volume":"9","author":"Green","year":"1992","journal-title":"J. Neurotrauma"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3171\/jns.2004.100.2.0272","article-title":"Rapid and selective cerebral hypothermia achieved using a cooling helmet","volume":"100","author":"Wang","year":"2004","journal-title":"J. Neurosurg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3171\/jns.1968.29.2.0113","article-title":"Study of Functional Recovery Produced by Delayed Localized Cooling After Spinal Cord Injury in Primates","volume":"29","author":"Albin","year":"1968","journal-title":"J. Neurosurg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"559","DOI":"10.6061\/clinics\/2014(08)10","article-title":"Neuroprotective effect of epidural hypothermia after spinal cord lesion in rats","volume":"69","author":"Barbosa","year":"2014","journal-title":"Clinics"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1089\/neu.2010.1360","article-title":"Hypothermia Prior to Decompression: Buying Time for Treatment of Acute Spinal Cord Injury","volume":"27","author":"Batchelor","year":"2010","journal-title":"J. Neurotrauma"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3171\/spi.2005.2.3.0308","article-title":"Effects of epidural hypothermic saline infusion on locomotor outcome and tissue preservation after moderate thoracic spinal cord contusion in rats","volume":"2","author":"Casas","year":"2005","journal-title":"J. Neurosurg. Spine"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1097\/00007632-200009150-00006","article-title":"The Role of Directly Applied Hypothermia in Spinal Cord Injury","volume":"25","author":"Dimar","year":"2000","journal-title":"Spine"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/j.spinee.2013.06.073","article-title":"The effect of hypothermia on sensory-motor function and tissue sparing after spinal cord injury","volume":"13","author":"Grulova","year":"2013","journal-title":"Spine J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1097\/BRS.0b013e31818018f6","article-title":"Neuroprotective Effect of Moderate Epidural Hypothermia After Spinal Cord Injury in Rats","volume":"33","author":"Ha","year":"2008","journal-title":"Spine"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1089\/neu.2015.3892","article-title":"A Direct Comparison of Three Clinically Relevant Treatments in a Rat Model of Cervical Spinal Cord Injury","volume":"32","author":"Hosier","year":"2015","journal-title":"J. Neurotrauma"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e607","DOI":"10.1016\/j.wneu.2019.05.229","article-title":"The Effect of Prophylactic Hypothermia on Neurophysiological and Functional Measures in the Setting of Iatrogenic Spinal Cord Impact Injury","volume":"129","author":"Jorge","year":"2019","journal-title":"World Neurosurg."},{"key":"ref_29","first-page":"885","article-title":"Body Cooling Ameliorating Spinal Cord Injury May Be Neurogenesis-, Anti-inflammation- and Angiogenesis-Associated in Rats","volume":"70","author":"Kao","year":"2011","journal-title":"J. Trauma Inj. Infect. Crit. Care"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4184\/asj.2015.9.1.1","article-title":"Effects of Methylprednisolone on Neuroprotective Effects of Delay Hypothermia on Spinal Cord Injury in Rat","volume":"9","author":"Karamouzian","year":"2015","journal-title":"Asian Spine J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1097\/00002517-200010000-00004","article-title":"Effects of Dexamethasone and of Local Hypothermia on Early and Late Tissue Electrolyte Changes in Experimental Spinal Cord Injury","volume":"13","author":"Kuchner","year":"2000","journal-title":"J. Spinal Disord."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/cne.22014","article-title":"Systemic hypothermia improves histological and functional outcome after cervical spinal cord contusion in rats","volume":"514","author":"Lo","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1097\/CCM.0b013e318232d97e","article-title":"Potential long-term benefits of acute hypothermia after spinal cord injury: Assessments with somatosensory-evoked potentials","volume":"40","author":"Maybhate","year":"2012","journal-title":"Crit. Care Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.neures.2011.12.003","article-title":"A novel thermoelectric cooling device using Peltier modules for inducing local hypothermia of the spinal cord: The effect of local electrically controlled cooling for the treatment of spinal cord injuries in conscious rats","volume":"72","author":"Morizane","year":"2012","journal-title":"Neurosci. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1080\/00207450601123456","article-title":"Local Transcutaneous Cooling of the Spinal Cord in the Rat: Effects on Long-Term Outcomes After Compression Spinal Cord Injury","volume":"118","author":"Cibur","year":"2008","journal-title":"Int. J. Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"E1551","DOI":"10.1097\/BRS.0b013e31826ff7f1","article-title":"Neuroprotective Effects of Hypothermia After Spinal Cord Injury in Rats","volume":"37","author":"Ok","year":"2012","journal-title":"Spine"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1097\/BRS.0000000000000845","article-title":"Effects of Therapeutic Hypothermia on Apoptosis and Autophagy After Spinal Cord Injury in Rats","volume":"40","author":"Seo","year":"2015","journal-title":"Spine"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.spinee.2017.10.066","article-title":"Neuroprotective assessment of prolonged local hypothermia post contusive spinal cord injury in rodent model","volume":"18","author":"Teh","year":"2018","journal-title":"Spine J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3171\/jns.1975.42.2.0150","article-title":"Effect of delayed local cooling on experimental spinal cord injury","volume":"42","author":"Thienprasit","year":"1975","journal-title":"J. Neurosurg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s007010050471","article-title":"Motor Function Changes in the Rat Following Severe Spinal Cord Injury","volume":"142","author":"Westergren","year":"2000","journal-title":"Acta Neurochir."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1179\/2045772315Y.0000000051","article-title":"Beneficial effects of local profound hypothermia and the possible mechanism after experimental spinal cord injury in rats","volume":"39","author":"Xu","year":"2015","journal-title":"J. Spinal Cord Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3171\/spi.2000.93.1.0085","article-title":"Beneficial effects of modest systemic hypothermia on locomotor function and histopathological damage following contusion-induced spinal cord injury in rats","volume":"93","author":"Yu","year":"2000","journal-title":"J. Neurosurg. Spine"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/sc.2012.161","article-title":"Systemic hypothermia in acute cervical spinal cord injury: A case-controlled study","volume":"51","author":"Dididze","year":"2013","journal-title":"Spinal Cord"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1227\/01.NEU.0000367557.77973.5F","article-title":"Clinical Outcomes Using Modest Intravascular Hypothermia After Acute Cervical Spinal Cord Injury","volume":"66","author":"Levi","year":"2010","journal-title":"Neurosurgery"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"550","DOI":"10.3171\/2014.2.SPINE13318","article-title":"Local cooling for traumatic spinal cord injury: Outcomes in 20 patients and review of the literature","volume":"20","author":"Hansebout","year":"2014","journal-title":"J. Neurosurg. Spine"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"8125","DOI":"10.1038\/s41598-020-64944-y","article-title":"Effects of local hypothermia\u2013rewarming on physiology, metabolism and inflammation of acutely injured human spinal cord","volume":"10","author":"Gallagher","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1097\/00007632-200112151-00015","article-title":"The Sygen\u00ae Multicenter Acute Spinal Cord Injury Study","volume":"26","author":"Geisler","year":"2001","journal-title":"Spine"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/sj.sc.3102008","article-title":"Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the ICCP panel: Clinical trial outcome measures","volume":"45","author":"Steeves","year":"2007","journal-title":"Spinal Cord"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/sc.2008.162","article-title":"ASIA impairment scale conversion in traumatic SCI: Is it related with the ability to walk? A descriptive comparison with functional ambulation outcome measures in 273 patients","volume":"47","author":"Hosman","year":"2009","journal-title":"Spinal Cord"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3171\/jns.2006.104.4.469","article-title":"Outcome following decompressive craniectomy for malignant swelling due to severe head injury","volume":"104","author":"Aarabi","year":"2006","journal-title":"J. Neurosurg."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.aucc.2020.05.005","article-title":"The effectiveness of early prophylactic hypothermia in adult patients with traumatic brain injury: A systematic review and meta-analysis","volume":"34","author":"Wu","year":"2020","journal-title":"Aust. Crit. Care"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1089\/neu.1993.10.263","article-title":"A Phase II Study of Moderate Hypothermia in Severe Brain Injury","volume":"10","author":"Clifton","year":"1993","journal-title":"J. Neurotrauma"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3171\/jns.1993.79.3.0354","article-title":"The use of moderate therapeutic hypothermia for patients with severe head injuries: A preliminary report","volume":"79","author":"Marion","year":"1993","journal-title":"J. Neurosurg."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1056\/NEJM199702203360803","article-title":"Treatment of Traumatic Brain Injury with Moderate Hypothermia","volume":"336","author":"Marion","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/jcbfm.1991.13","article-title":"Marked Protection by Moderate Hypothermia after Experimental Traumatic Brain Injury","volume":"11","author":"Clifton","year":"1991","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Carney, N., Totten, A.M., O\u2019Reilly, C., Ullman, J.S., Hawryluk, G.W.J., Bell, M.J., Bratton, S.L., Chesnut, R., Harris, O.A., and Kissoon, N. (2016). Guidelines for Management of Severe Traumatic Brain Injury, Brain Trauma Foundation. [4th ed.].","DOI":"10.1227\/NEU.0000000000001432"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/jcbfm.1992.120","article-title":"The effect of profound levels of hypothermia (below 14 degrees C) on canine cerebral metabolism","volume":"12","author":"Michenfelder","year":"1992","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/sj.sc.3101516","article-title":"Post-traumatic moderate systemic hypothermia reduces TUNEL positive cells following spinal cord injury in rat","volume":"42","author":"Shibuya","year":"2004","journal-title":"Spinal Cord"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s11064-008-9795-5","article-title":"Does Hypothermic Treatment Provide an Advantage After Spinal Cord Injury Until Surgery? An Experimental Study","volume":"34","author":"Duz","year":"2008","journal-title":"Neurochem. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1097\/00007632-200008010-00004","article-title":"Effects of core body temperature on changes in spinal somatosensory-evoked potential in acute spinal cord compression injury: An experimental study in the rat","volume":"25","author":"Jou","year":"2000","journal-title":"Spine"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1089\/neu.2017.5357","article-title":"Predicting Injury Severity and Neurological Recovery after Acute Cervical Spinal Cord Injury: A Comparison of Cerebrospinal Fluid and Magnetic Resonance Imaging Biomarkers","volume":"35","author":"Dalkilic","year":"2018","journal-title":"J. Neurotrauma"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1089\/neu.2007.0349","article-title":"Multiplex Assessment of Cytokine and Chemokine Levels in Cerebrospinal Fluid following Severe Pediatric Traumatic Brain Injury: Effects of Moderate Hypothermia","volume":"24","author":"Buttram","year":"2007","journal-title":"J. Neurotrauma"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1001\/jama.1981.03310490035022","article-title":"Disseminated intravascular coagulation during rewarming following hypothermia","volume":"245","author":"Mahajan","year":"1981","journal-title":"JAMA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"519","DOI":"10.7326\/0003-4819-89-4-519","article-title":"Hypothermia: Pathophysiology, Clinical Settings, and Management","volume":"89","author":"Reuler","year":"1978","journal-title":"Ann. Intern. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1177\/000313480707300508","article-title":"Increased Risk of Deep Venous Thrombosis with Endovascular Cooling in Patients with Traumatic Head Injury","volume":"73","author":"Simosa","year":"2007","journal-title":"Am. Surg."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3171\/2016.1.SPINE151317","article-title":"Safety profile and probe placement accuracy of intraspinal pressure monitoring for traumatic spinal cord injury: Injured Spinal Cord Pressure Evaluation study","volume":"25","author":"Phang","year":"2016","journal-title":"J. Neurosurg. Spine"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1161\/01.STR.0000240509.05587.a2","article-title":"Frequency and Determinants of Nonpublication of Research in the Stroke Literature","volume":"37","author":"Sanossian","year":"2006","journal-title":"Stroke"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/6\/1585\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:35:51Z","timestamp":1760135751000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/11\/6\/1585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,13]]},"references-count":67,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["jcm11061585"],"URL":"https:\/\/doi.org\/10.3390\/jcm11061585","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,13]]}}}