{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T17:05:17Z","timestamp":1787245517404,"version":"build-2736575974"},"reference-count":36,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The opioid use disorder is an international public health problem. Over the past 20 years it has been the subject of numerous publications concerning patients treated for chronic pain other than cancer-related. Patients with cancer-related pain are also at risk of opioid use disorder. The primary objective of this literature review was to determine the prevalence of opioid use disorder in patients with cancer-related chronic pain. Its secondary objective was to identify the characteristics of these opioid users. Methods: This is a literature review of studies published over the last twenty years, from 1 January 2000 to 31 December 2020 identified by searching the three main medical databases: Pubmed, Cochrane, and Embase. A meta-analysis took account of between and within-study variability with the use of random-effects models estimated by the DerSimonian and Laird method. Results: The prevalence of opioid use disorder was 8% (1\u201320%) and of the risk of use disorder was 23.5% (19.5\u201327.8%) with I2 values of 97.8% and 88.7%, respectively. Conclusions: Further studies are now needed on the prevalence of opioid use disorder in patients treated for cancer-related chronic pain. A screening scale adapted to this patient population is urgently needed.<\/jats:p>","DOI":"10.3390\/jcm11061594","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T03:34:13Z","timestamp":1647401653000},"page":"1594","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Prevalence of Opioid Use Disorder among Patients with Cancer-Related Pain: A Systematic Review"],"prefix":"10.3390","volume":"11","author":[{"given":"C\u00e9line","family":"Preux","sequence":"first","affiliation":[{"name":"Palliative Care Center, CHU Clermont-Ferrand, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Bertin","sequence":"additional","affiliation":[{"name":"Palliative Care Center, CHU Clermont-Ferrand, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a","family":"Tarot","sequence":"additional","affiliation":[{"name":"Palliative Care Center, CHU Clermont-Ferrand, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Authier","sequence":"additional","affiliation":[{"name":"Neuro-Dol, Service Pharmacologie M\u00e9dicale, Centres d\u2019Addictovigilance et Pharmacovigilance, Centre Evaluation et Traitement de la Douleur, Inserm, CHU Clermont-Ferrand, Universit\u00e9 de Clermont Auvergne, F-63001 Clermont-Ferrand, France"},{"name":"Institut Analg\u00e9sia, Facult\u00e9 de M\u00e9decine, BP38, F-63001 Clermont-Ferrand, France"},{"name":"Observatoire Fran\u00e7ais des M\u00e9dicaments Antalgiques\/French Monitoring Centre for Analgesic Drugs, Universit\u00e9 Clermont-Ferrand, F-63001 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Pinol","sequence":"additional","affiliation":[{"name":"Centre de Documentation et Recherche de la Facult\u00e9 de M\u00e9decine, CHU Clermont-Ferrand, Universit\u00e9 de Clermont Auvergne, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Brugnon","sequence":"additional","affiliation":[{"name":"Palliative Care Center, CHU Clermont-Ferrand, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3778-7161","authenticated-orcid":false,"given":"Bruno","family":"Pereira","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Biostatistiques, Direction de la Recherche Clinique et de l\u2019Innovation, CHU Clermont-Ferrand, F-63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5712-8887","authenticated-orcid":false,"given":"Virginie","family":"Guastella","sequence":"additional","affiliation":[{"name":"Palliative Care Center, CHU Clermont-Ferrand, F-63000 Clermont-Ferrand, France"},{"name":"Neuro-Dol, Service Pharmacologie M\u00e9dicale, Centres d\u2019Addictovigilance et Pharmacovigilance, Centre Evaluation et Traitement de la Douleur, Inserm, CHU Clermont-Ferrand, Universit\u00e9 de Clermont Auvergne, F-63001 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1002\/(SICI)1097-0142(19991101)86:9<1848::AID-CNCR29>3.0.CO;2-M","article-title":"The Effects of Pain Severity on Health-Related Quality of Life: A Study of Chinese Cancer Patients","volume":"86","author":"Wang","year":"1999","journal-title":"Cancer"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1080\/028418698429973","article-title":"Cancer Pain\u2014A Provoker of Emotional, Social and Existential Distress","volume":"37","author":"Strang","year":"1998","journal-title":"Acta Oncol."},{"key":"ref_3","unstructured":"(2021, July 19). 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