{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:29:37Z","timestamp":1785896977253,"version":"3.56.0"},"reference-count":27,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Currently, brachytherapy is the most commonly used therapeutic approach for uveal melanomas. Surgical resection by means of endoresection or exoresection is an alternative approach. The present report recounts our experience over 15 years in the treatment of uveal melanoma using a combined approach of resection surgery with brachytherapy. This is a single-center observational retrospective cohort study in which we describe clinical outcomes, complications and survival in 35 cases of melanoma of the iris or the ciliary body after a combination of surgery and brachytherapy or brachytherapy alone. Local treatment of the tumor was successful in all cases with surgery and brachytherapy. The most frequent complications were scleromalacia, bullous keratopathy, retinal toxicity, cataracts, hypotonia, and photophobia. There were three cases of recurrence, all of which were found in the group of patients who had received brachytherapy alone, and in one case we had to perform a secondary enucleation due to tumor growth after brachytherapy. At present, only one patient has died during follow-up due to liver metastases six years after the start of treatment. In carefully selected patients, this approach can be effective and safe, as long as a close follow-up is carried out after surgery.<\/jats:p>","DOI":"10.3390\/jcm11061616","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T03:34:13Z","timestamp":1647401653000},"page":"1616","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical Outcomes after Surgical Resection Combined with Brachytherapy for Uveal Melanomas"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2872-2940","authenticated-orcid":false,"given":"Isabel","family":"Relimpio-L\u00f3pez","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Virgen Macarena University Hospital, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7664-676X","authenticated-orcid":false,"given":"Antonio Manuel","family":"Garrido-Hermosilla","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Virgen Macarena University Hospital, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Espejo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Virgen Macarena University Hospital, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5417-1495","authenticated-orcid":false,"given":"Mar\u00eda","family":"Gessa-Sorroche","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Virgen Macarena University Hospital, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Coca","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Virgen Macarena University Hospital, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0591-0401","authenticated-orcid":false,"given":"Belen","family":"Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Virgen Macarena University Hospital, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jes\u00fas","family":"D\u00edaz-Granda","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Virgen Macarena University Hospital, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Ponte","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Virgen Macarena University Hospital, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Cano","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Virgen Macarena University Hospital, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Rodr\u00edguez de la R\u00faa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Virgen Macarena University Hospital, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Carrasco-Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Virgen Macarena University Hospital, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"M\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Virgen Macarena University Hospital, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Saavedra","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Virgen Macarena University Hospital, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Ontanilla","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Virgen Macarena University Hospital, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Caparr\u00f3s-Escudero","sequence":"additional","affiliation":[{"name":"Department of Radiology, Virgen Macarena University Hospital, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"R\u00edos","sequence":"additional","affiliation":[{"name":"Department of Pathology, Virgen Macarena University Hospital, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5123-9597","authenticated-orcid":false,"given":"Jos\u00e9 Antonio","family":"Terr\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Radio Physics, Virgen Macarena University Hospital, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ijrobp.2005.01.022","article-title":"Radiation complications and tumor control after 125i plaque brachytherapy for ocular melanoma","volume":"63","author":"Jensen","year":"2005","journal-title":"Int. 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