{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T08:07:03Z","timestamp":1776586023825,"version":"3.51.2"},"reference-count":57,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Program of Guangzhou, China","award":["202102010216"],"award-info":[{"award-number":["202102010216"]}]},{"name":"the National Key Research and Development Project of China","award":["2020YFA0112701"],"award-info":[{"award-number":["2020YFA0112701"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171057"],"award-info":[{"award-number":["82171057"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This study aimed to analyze the quantitative vascular biomarkers of filtering bleb function at different depths using anterior segment optical coherence tomography angiography (AS-OCTA). This cross-sectional study is registered on Clinicaltrails.gov (NCT 04515017). Forty-six eyes with primary open-angle glaucoma that had undergone trabeculectomy with mitomycin-C for more than six months were included. Vessel density (VD) and vessel diameter index (VDI) in the superficial layer (SL), Tenon\u2019s layer (TL), and deep layer (DL) of the bleb were obtained. The VD and VDI were higher in the failure group (both p = 0.000). Significant correlations were found between the SL, TL, DL\u2019s VDI, and IOP in the success group (p = 0.013, 0.016, 0.031, respectively). The VD of the TL and DL were related to IOP in the failure group (p = 0.012, 0.009). Tenon\u2019s VD (TVD) and Tenon\u2019s VDI (TVDI) correlated with IOP adjusting for TVD, TVDI, and the Indiana Bleb Appearance Grading Scale (IBAGS) (p = 0.009, 0.043) or Kenfeld grading system (KGS) (p = 0.011, 0.016). The area under curve (AUC) of the TVD, TVDI, IBAGS, and KGS to predict surgery failure were 0.960, 0.925, 0.770, and 0.850. AS-OCTA realized the quantitative evaluation of vessels, especially the invisible vascularity beneath the conjunctiva. TVD and TVDI as detected by AS-OCTA better reflected bleb function than conventional grading systems.<\/jats:p>","DOI":"10.3390\/jcm11061661","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T22:09:58Z","timestamp":1647468598000},"page":"1661","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Characteristic Assessment of Angiographies at Different Depths with AS-OCTA: Implication for Functions of Post-Trabeculectomy Filtering Bleb"],"prefix":"10.3390","volume":"11","author":[{"given":"Man","family":"Luo","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Guangzhou 510060, China"},{"name":"Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China"},{"name":"Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China"},{"name":"Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingting","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Guangzhou 510060, China"},{"name":"Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China"},{"name":"Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China"},{"name":"Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Xiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Guangzhou 510060, China"},{"name":"Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China"},{"name":"Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China"},{"name":"Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Guangzhou 510060, China"},{"name":"Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China"},{"name":"Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China"},{"name":"Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Ling","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Guangzhou 510060, China"},{"name":"Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China"},{"name":"Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China"},{"name":"Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haishun","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Guangzhou 510060, China"},{"name":"Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China"},{"name":"Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China"},{"name":"Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiqing","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Guangzhou 510060, China"},{"name":"Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China"},{"name":"Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China"},{"name":"Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehong","family":"Zhuo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Guangzhou 510060, China"},{"name":"Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China"},{"name":"Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou 510060, China"},{"name":"Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br. 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